PD 128483 | CAS# 115688-97-6 | antipsychotic

MedKoo Cat#: 414806 | Name: PD 128483

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PD 128483 is a potential antipsychotic drug candidate found to be a potent frameshift mutagen.

Chemical Structure

PD 128483

CAS#115688-97-6

Theoretical Analysis

MedKoo Cat#: 414806

Name: PD 128483

CAS#: 115688-97-6

Chemical Formula: C11H15N3S

Exact Mass: 221.0987

Molecular Weight: 221.32

Elemental Analysis: C, 59.70; H, 6.83; N, 18.99; S, 14.49

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

PD 128483; PD128483; PD-128483; CCRIS4394; CCRIS-4394; CCRIS 4394

IUPAC/Chemical Name

4,5,5a,6,7,8-Hexahydro-6-methylthiazolo(4,5-f)quinoline-2-amine

InChi Key

XFJSSDHKIXXJLM-UHFFFAOYSA-N

InChi Code

InChI=1S/C11H15N3S/c1-14-6-2-3-7-8(14)4-5-9-10(7)13-11(12)15-9/h3,8H,2,4-6H2,1H3,(H2,12,13)

SMILES Code

NC(S1)=NC2=C1CCC3N(C)CCC=C23

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 221.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Meltzer LT, Caprathe BW, Christoffersen CL, Corbin AE, Jaen JC, Ninteman FW, Pugsley TA, Serpa KA, Shih YH, Whetzel SZ, et al. Pharmacological profile of the dopamine partial agonist, (+/-)-PD 128483 and its enantiomers. J Pharmacol Exp Ther. 1993 Sep;266(3):1177-89. PMID: 8103791. 2: Lin MY, Walters DE. The D2 autoreceptor agonists SND 919 and PD 128483 decrease stereotypy in developing rats. Life Sci. 1994;54(1):PL17-22. doi: 10.1016/0024-3205(94)00581-8. PMID: 7902951. 3: Vanover KE, Woolverton WL. Behavioral effects of the dopamine autoreceptor agonist PD 128483 alone and in combination with cocaine. J Pharmacol Exp Ther. 1994 Sep;270(3):1049-56. PMID: 7932152. 4: Lin MY, Walters DE. Dopamine D2 autoreceptors in rats are behaviorally functional at 21 but not 10 days of age. Psychopharmacology (Berl). 1994 Mar;114(2):262-8. doi: 10.1007/BF02244847. PMID: 7838918. 5: Kropko ML, Jaen JC, Theiss JC, Wold S, Caprathe BW, Wise LD. Chemical purity and mutagenicity: case study of a drug in development. Mutat Res. 1992 Apr;281(4):233-8. doi: 10.1016/0165-7992(92)90014-9. Erratum in: Mutat Res 1992 Aug;282(4):287. PMID: 1373215.