Synonym
Pca 50941; Pca50941; Pca-50941
IUPAC/Chemical Name
3-(2-(1,1-dioxido-3-oxobenzo[d]isothiazol-2(3H)-yl)ethyl) 5-((tetrahydro-2H-pyran-2-yl)methyl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
InChi Key
SOOCCEZHZUEQKC-UHFFFAOYSA-N
InChi Code
InChI=1S/C30H31N3O10S/c1-18-25(29(35)42-15-13-32-28(34)23-11-3-4-12-24(23)44(32,39)40)27(20-8-7-9-21(16-20)33(37)38)26(19(2)31-18)30(36)43-17-22-10-5-6-14-41-22/h3-4,7-9,11-12,16,22,27,31H,5-6,10,13-15,17H2,1-2H3
SMILES Code
CC1=C(C(OCCN2C(c3c(S2(=O)=O)cccc3)=O)=O)C(c4cc([N+]([O-])=O)ccc4)C(C(OCC5CCCCO5)=O)=C(N1)C
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
625.65
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Zapater P, Javaloy J, Román JF, Vidal MT, Horga JF. Anticonvulsant effects of nimodipine and two novel dihydropyridines (PCA 50922 and PCA 50941) against seizures elicited by pentylenetetrazole and electroconvulsive shock in mice. Brain Res. 1998 Jun 15;796(1-2):311-4. doi: 10.1016/s0006-8993(98)00352-7. PMID: 9689485.
2: Priego J, González-Morales MA, Cillero FJ, Villarroya M, Sunkel C, de Casa- Juana MF, López MG, Artalejo CR, de Pascual R, García AG. PCA 50941, a novel Ca2+ channel agonist. Eur J Pharmacol. 1993 Oct 12;243(1):25-34. doi: 10.1016/0014-2999(93)90163-c. PMID: 7504630.
3: Fernández N, García JL, López MG, García AG, Diéguez G. PCA50941, a new 1,4-dihydropyridine, reverses endothelin-induced cardiogenic shock in the anesthetized goat. Life Sci. 1998;62(21):1933-42. doi: 10.1016/s0024-3205(98)00162-3. PMID: 9619842.
4: Montiel C, de la Fuente MT, Vinet R, del Valle M, Gandía L, Artalejo AR, García AG. Interactions between Ca2+, PCA50941 and Bay K 8644 in bovine chromaffin cells. Eur J Pharmacol. 1994 Aug 16;268(3):293-303. doi: 10.1016/0922-4106(94)90053-1. PMID: 7528677.
