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MedKoo Cat#: 414778 | Name: Pholedrine HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Pholedrine HCl is an Autonomic Agent. It is a a sympathomimetic vasoconstrictive drug.

Chemical Structure

Pholedrine HCl
Pholedrine HCl
CAS#877-86-1 (HCl)

Theoretical Analysis

MedKoo Cat#: 414778

Name: Pholedrine HCl

CAS#: 877-86-1 (HCl)

Chemical Formula: C10H16ClNO

Exact Mass: 201.0920

Molecular Weight: 201.69

Elemental Analysis: C, 59.55; H, 8.00; Cl, 17.58; N, 6.94; O, 7.93

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
877-86-1 (HCl); 370-14-9 (free base)
Synonym
Pholedrine hydrochloride; Pholedrine HCl
IUPAC/Chemical Name
4-Hydroxymethamphetamine (hydrochloride)
InChi Key
APSKAFWNZDJCNR-UHFFFAOYSA-N
InChi Code
InChI=1S/C10H15NO.ClH/c1-8(11-2)7-9-3-5-10(12)6-4-9;/h3-6,8,11-12H,7H2,1-2H3;1H
SMILES Code
CNC(CC1=CC=C(O)C=C1)C.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 201.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bánhidy F, Acs N, Puhó EH, Czeizel AE. Teratogenic potential of pholedrine: a sympathomimetic vasoconstrictive drug - a population-based case-control study. Congenit Anom (Kyoto). 2010 Jun;50(2):122-8. doi: 10.1111/j.1741-4520.2010.00276.x. Epub 2010 Feb 22. PubMed PMID: 20184643. 2: Petzsche M, Fürst W, Fahr A, Sziegoleit W. [Preparation, detection and pharmacokinetic behavior of pholedrine sulfuric acid ester. 6. Determination of pholedrine and pholedrine sulfuric acid esters in plasma after oral administration of pholedrine]. Pharmazie. 1988 Dec;43(12):875. German. PubMed PMID: 3247384. 3: Wilhelm H, Wilhelm B, Kriegbaum C. Interaction of the indirectly acting topical sympathomimetics cocaine and pholedrine. Ger J Ophthalmol. 1996 May;5(3):168-70. PubMed PMID: 8803579. 4: Fürst W, Neubert R, Petzsche M, Noll E. [Synthesis, detection and pharmacokinetic behavior of pholedrine sulphate esters. 7. Comparison of free- and sustained-release tablets in vivo and in vitro]. Pharmazie. 1989 Mar;44(3):234. German. PubMed PMID: 2748712. 5: Wilhelm H, Schäffer E. [Pholedrine for determining the site of Horner syndrome]. Klin Monbl Augenheilkd. 1994 Mar;204(3):169-75. German. PubMed PMID: 8196303. 6: Bates AT, Chamberlain S, Champion M, Foley L, Hughes E, Jani B, Mehta H, Smith SE. Pholedrine: a substitute for hydroxyamphetamine as a diagnostic eyedrop test in Horner's syndrome. J Neurol Neurosurg Psychiatry. 1995 Feb;58(2):215-7. PubMed PMID: 7876854; PubMed Central PMCID: PMC1073320. 7: Petzsche M, Fürst W. [Preparation, detection and pharmacokinetic behavior of pholedrine sulfuric acid ester. 5. Methods for determining pholedrine and pholedrine sulfuric acid esters in plasma]. Pharmazie. 1988 Dec;43(12):867-8. German. PubMed PMID: 3247382. 8: Römhild W, Krause D, Bartels H, Ghanem A, Schöning R, Wittig H. LC-MS/MS analysis of pholedrine in a fatal intoxication case. Forensic Sci Int. 2003 Apr 23;133(1-2):101-6. PubMed PMID: 12742695. 9: Gruber G. [Evaluation of the effectiveness of Thomasin (etilefrin) in hypotensive and/or orthostatic circulatory disorders in comparison with pholedrine and placebo (double-blind study)]. Z Arztl Fortbild (Jena). 1982 Feb 15;76(4):149-53. German. PubMed PMID: 6125062. 10: Peinhardt GP. High-performance liquid chromatographic determination of pholedrine in human serum using ion-pair extraction and amperometric detection. J Chromatogr B Biomed Sci Appl. 1999 Apr 16;726(1-2):309-12. PubMed PMID: 10348201. 11: ZINNITZ F, SIMM R. [Narcosis and veritol (pholedrine) action]. Pharmazie. 1961 Feb;16:63-5. German. PubMed PMID: 13788594. 12: Peinhardt G. Radioimmunoassay for the determination of pholedrine. Pharmazie. 1997 Dec;52(12):937-9. PubMed PMID: 9442557. 13: KADEN W. [Experiences with depot pholedrine as a depot sympathomimetic in peridural anesthesia]. Dtsch Gesundheitsw. 1960 Apr 14;15:783-5. German. PubMed PMID: 14408332. 14: Petzsche M, Fürst W. [Preparation, detection and pharmacokinetic behavior of pholedrine sulfuric acid esters. 4. Detection and determination of pholedrine sulfuric acid esters in urine]. Pharmazie. 1988 Apr;43(4):291-2. German. PubMed PMID: 3413224. 15: Petzsche M, Noll E, Hartung S, Fürst W. [Preparation, detection and pharmacokinetic behavior of pholedrine sulfuric acid esters. 3. Determination of free and bound pholedrine in urine]. Pharmazie. 1988 Apr;43(4):291. German. PubMed PMID: 3413223. 16: Petzsche M, Fürst W. [Preparation, detection and pharmacokinetic behavior of pholedrine sulfuric acid ester. 2. Transformation of pholedrin and pholedrin sulfuric acid esters with dinitroflorobenzene]. Pharmazie. 1988 Feb;43(2):135. German. PubMed PMID: 3393585. 17: Scheler C, Röpke F. [Blood flow in the umbilical artery in maternal hypotension and after therapy with Pholedrine longo--a Doppler ultrasound study]. Z Geburtshilfe Perinatol. 1993 Jul-Aug;197(4):191-4. German. PubMed PMID: 8212771. 18: Glös J, Uhlmann B, Adler K, Lange R, Taut M, Elix HH. [Attempted suicide by intake of pholedrine]. Z Gesamte Inn Med. 1983 Nov 15;38(22):617-9. German. PubMed PMID: 6141673. 19: Elmes PC, Jefferson AA. Action of Pholedrine and Neosynephrin. Br Med J. 1942 Jul 18;2(4254):65-7. PubMed PMID: 20784336; PubMed Central PMCID: PMC2163513. 20: Neubert R, Albrecht G, Taube C, Weiss M, Fürst W. Influence of ion-pair-formation on the pharmacokinetic properties of drugs. Part 3: Influence of hexylsalicylic acid on the pharmacokinetics of pholedrine. Pharmazie. 1988 Sep;43(9):632-3. PubMed PMID: 3244733.