Calendoflavoside | CAS#55033-90-4 | Antioxidant/Osteoclastogenic glycoside

MedKoo Cat#: 465406 | Name: Calendoflavoside

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Isorhamnetin 3-O-neohesperidoside is a flavonoid glycoside that has been found in A. salicina and has antioxidant and osteoclastogenic activities. It inhibits xanthine oxidase and scavenges superoxide radicals in a cell-free assay (IC50s = 48.75 and 30 µg/ml, respectively). Isorhamnetin 3-O-neohesperidoside promotes RANKL-induced osteoclastogenesis of mouse bone marrow-derived macrophages in a concentration-dependent manner.

Chemical Structure

Calendoflavoside

CAS#55033-90-4

Theoretical Analysis

MedKoo Cat#: 465406

Name: Calendoflavoside

CAS#: 55033-90-4

Chemical Formula: C28H32O16

Exact Mass: 624.1690

Molecular Weight: 624.55

Elemental Analysis: C, 53.85; H, 5.16; O, 40.99

Price and Availability

Size	Price	Availability	Quantity
10mg	USD 350.00	2 Weeks
50mg	USD 1,050.00	2 Weeks

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Related CAS #

No Data

Synonym

Calendoflavoside; Isorhamnetin-3-O-nehesperridin; Isorhamnetin-3-O-neohesperidine; Isorhamnetin 3-O-neohesperoside; Isorhamnetin 3-O-neohesperidoside;

IUPAC/Chemical Name

3-(((2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-chromen-4-one

InChi Key

QHLKSZBFIJJREC-SPSUIZEHSA-N

InChi Code

InChI=1S/C28H32O16/c1-9-18(33)21(36)23(38)27(40-9)44-26-22(37)19(34)16(8-29)42-28(26)43-25-20(35)17-13(32)6-11(30)7-15(17)41-24(25)10-3-4-12(31)14(5-10)39-2/h3-7,9,16,18-19,21-23,26-34,36-38H,8H2,1-2H3/t9-,16+,18-,19+,21+,22-,23+,26+,27-,28-/m0/s1

SMILES Code

O=C1C(O[C@H]2[C@H](O[C@H]3[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O3)[C@@H](O)[C@H](O)[C@@H](CO)O2)=C(OC4=CC(O)=CC(O)=C14)C5=CC=C(O)C(OC)=C5

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

	Solvent	mg/mL	mM
Solubility
	DMF	30.0	48.03
	DMSO	30.0	48.03
	Ethanol	30.0	48.03

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 624.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Das P, Majumder R, Mandal M, Basak P. In-Silico approach for identification of effective and stable inhibitors for COVID-19 main protease (Mpro) from flavonoid based phytochemical constituents of Calendula officinalis. J Biomol Struct Dyn. 2020 Jul 24:1-16. doi: 10.1080/07391102.2020.1796799. Epub ahead of print. PMID: 32705952; PMCID: PMC7441784.