Hydromethylthionine | CAS# 613-11-6 | Treatment of Alzheimer's Disease (AD)

MedKoo Cat#: 414748 | Name: Hydromethylthionine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Hydromethylthionine is used in the treatment of Alzheimer's Disease (AD)

Chemical Structure

Hydromethylthionine

CAS#613-11-6

Theoretical Analysis

MedKoo Cat#: 414748

Name: Hydromethylthionine

CAS#: 613-11-6

Chemical Formula: C16H19N3S

Exact Mass: 285.1300

Molecular Weight: 285.41

Elemental Analysis: C, 67.33; H, 6.71; N, 14.72; S, 11.23

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Hydromethylthionine; Panatone; Leukomethylene blue; IHU4GYZ2R3

IUPAC/Chemical Name

N,N,N',N'-Tetramethyl-10H-phenothiazine-3,7-diamine

InChi Key

QTWZICCBKBYHDM-UHFFFAOYSA-N

InChi Code

InChI=1S/C16H19N3S/c1-18(2)11-5-7-13-15(9-11)20-16-10-12(19(3)4)6-8-14(16)17-13/h5-10,17H,1-4H3

SMILES Code

CN(C)C1=CC(SC2=CC(N(C)C)=CC=C2N3)=C3C=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 285.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Hashweh NN, Bartochowski Z, Khoury R, Grossberg GT. An evaluation of hydromethylthionine as a treatment option for Alzheimer's disease. Expert Opin Pharmacother. 2020 Apr;21(6):619-627. doi: 10.1080/14656566.2020.1719066. Epub 2020 Feb 8. PMID: 32037892. 2: Shiells H, Schelter BO, Bentham P, Baddeley TC, Rubino CM, Ganesan H, Hammel J, Vuksanovic V, Staff RT, Murray AD, Bracoud L, Wischik DJ, Riedel G, Gauthier S, Jia J, Moebius HJ, Hardlund J, Kipps CM, Kook K, Storey JMD, Harrington CR, Wischik CM. Concentration-Dependent Activity of Hydromethylthionine on Clinical Decline and Brain Atrophy in a Randomized Controlled Trial in Behavioral Variant Frontotemporal Dementia. J Alzheimers Dis. 2020;75(2):501-519. doi: 10.3233/JAD-191173. PMID: 32280089; PMCID: PMC7306898. 3: Schelter BO, Shiells H, Baddeley TC, Rubino CM, Ganesan H, Hammel J, Vuksanovic V, Staff RT, Murray AD, Bracoud L, Riedel G, Gauthier S, Jia J, Bentham P, Kook K, Storey JMD, Harrington CR, Wischik CM. Concentration- Dependent Activity of Hydromethylthionine on Cognitive Decline and Brain Atrophy in Mild to Moderate Alzheimer's Disease. J Alzheimers Dis. 2019;72(3):931-946. doi: 10.3233/JAD-190772. PMID: 31658058; PMCID: PMC6918900. 4: Bentham P, Staff RT, Schelter BO, Shiells H, Harrington CR, Wischik CM. Long- Term Hydromethylthionine Treatment Is Associated with Delayed Clinical Onset and Slowing of Cerebral Atrophy in a Pre-Symptomatic P301S MAPT Mutation Carrier. J Alzheimers Dis. 2021 Aug 5. doi: 10.3233/JAD-210390. Epub ahead of print. PMID: 34366349. 5: Lee HE, Lim D, Lee JY, Lim SM, Pae AN. Recent tau-targeted clinical strategies for the treatment of Alzheimer's disease. Future Med Chem. 2019 Aug;11(15):1845-1848. doi: 10.4155/fmc-2019-0151. PMID: 31517533. 6: Wise J. No "breakthrough" in Alzheimer's disease. BMJ. 2016 Aug 16;354:i4474. doi: 10.1136/bmj.i4474. PMID: 27531826. 7: Riedel G, Klein J, Niewiadomska G, Kondak C, Schwab K, Lauer D, Magbagbeolu M, Steczkowska M, Zadrozny M, Wydrych M, Cranston A, Melis V, Santos RX, Theuring F, Harrington CR, Wischik CM. Mechanisms of Anticholinesterase Interference with Tau Aggregation Inhibitor Activity in a Tau-Transgenic Mouse Model. Curr Alzheimer Res. 2020;17(3):285-296. doi: 10.2174/1567205017666200224120926. PMID: 32091331; PMCID: PMC7403648. 8: Gui WF, Xu S, Dang ZS, Zhao YM. In Vitro and in Vivo Effect of MAPK Signal Transduction Pathway Inhibitors on Echinococcus multilocularis. J Parasitol. 2019 Feb;105(1):146-154. PMID: 30807708. 9: Zhang X, Jia L, Tao X, Ding J, Hua K. Intraoperative nerve staining in nerve- sparing radical hysterectomy: a pilot study. Arch Gynecol Obstet. 2017 Mar;295(3):737-741. doi: 10.1007/s00404-016-4284-6. Epub 2017 Jan 13. PMID: 28084524. 10: Sabaghnia N, Janmohammadi M, Dalili M, Karimi Z, Rostamnia S. Euphorbia leaf extract-assisted sustainable synthesis of Au NPs supported on exfoliated GO for superior activity on water purification: reduction of 4-NP and MB. Environ Sci Pollut Res Int. 2019 Apr;26(12):11719-11729. doi: 10.1007/s11356-019-04437-2. Epub 2019 Feb 26. PMID: 30806928.