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MedKoo Cat#: 414747 | Name: Pamaquine HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Pamaquine HCl is an 8-aminoquinoline drug formerly used for the treatment of malaria.

Chemical Structure

Pamaquine HCl
Pamaquine HCl
CAS#63680-62-6 (HCl)

Theoretical Analysis

MedKoo Cat#: 414747

Name: Pamaquine HCl

CAS#: 63680-62-6 (HCl)

Chemical Formula: C19H30ClN3O

Exact Mass: 351.2077

Molecular Weight: 351.92

Elemental Analysis: C, 64.85; H, 8.59; Cl, 10.07; N, 11.94; O, 4.55

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
63680-62-6 (HCl); 635-05-2 (naphthoate); 491-92-9 (free base)
Synonym
Pamaquine hydrochloride; Pamaquine HCl
IUPAC/Chemical Name
Quinoline, 8-((4-(diethylamino)-1-methylbutyl)amino)-6-methoxy-, hydrochloride
InChi Key
DKMGXHJWXGGADS-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H29N3O.ClH/c1-5-22(6-2)12-8-9-15(3)21-18-14-17(23-4)13-16-10-7-11-20-19(16)18;/h7,10-11,13-15,21H,5-6,8-9,12H2,1-4H3;1H
SMILES Code
COC1=CC(NC(C)CCCN(CC)CC)=C2N=CC=CC2=C1.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 351.92 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Sweeney AW, Blackburn CR, Rieckmann KH. Short report: the activity of pamaquine, an 8-aminoquinoline drug, against sporozoite-induced infections of Plasmodium vivax (New Guinea strains). Am J Trop Med Hyg. 2004 Aug;71(2):187-9. PubMed PMID: 15306708. 2: Matsuno T, Hariguchi F, Okamoto T. Anticoccidial activity of 8-aminoquinolines, pamaquine, primaquine and several molecular complexes and salts of pamaquine, against Eimeria tenella, E. necatrix, E. acervulina, E. maxima, and E. brunetti in battery experiments. J Vet Med Sci. 1991 Feb;53(1):13-7. PubMed PMID: 1830767. 3: LOKEN AC, HAYMAKER W. Pamaquine poisoning in man, with a clinicopathologic study of one case. Am J Trop Med Hyg. 1949 May;29(3):341-52. PubMed PMID: 18145865.