Zastaprazan, also known as JP-1366, is a proton pump inhibitor. JP-1366 mediates strong, selective, and dose-dependent inhibition of H+/K+-ATPase. JP-1366 significantly suppressed gastric acid secretion in histamine-treated pylorus-ligated rats in a dose-dependent manner. Additionally, JP-1366 inhibited histamine-stimulated gastric acid secretion in the HPD model. JP-1366 exhibited a more than 2-fold higher inhibitory effect on esophageal injury than TAK-438 in GERD lesions and had a more potent inhibitory effect in indomethacin- or aspirin-induced gastric ulcer rat models than TAK-438. Additionally, JP-1366 inhibited gastric ulcers.
MedKoo Cat#: 414730
Name: Zastaprazan
CAS#: 2133852-18-1
Chemical Formula: C22H26N4O
Exact Mass: 362.2107
Molecular Weight: 362.48
Elemental Analysis: C, 72.90; H, 7.23; N, 15.46; O, 4.41
The following data is based on the product molecular weight 362.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
