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MedKoo Cat#: 414712 | Name: Pralidoxime mesylate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Pralidoxime mesylate is a Cholinesterase Reactivator

Chemical Structure

Pralidoxime mesylate
Pralidoxime mesylate
CAS#154-97-2 (mesylate)

Theoretical Analysis

MedKoo Cat#: 414712

Name: Pralidoxime mesylate

CAS#: 154-97-2 (mesylate)

Chemical Formula:

Exact Mass:

Molecular Weight:

Elemental Analysis:

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
154-97-2 (mesylate); 94-63-3 (iodide); 51-15-0 (Cl)
Synonym
Pralidoxime mesylate; P2S; 2-Pam methanesulfonate; Contrathion
IUPAC/Chemical Name
(E)-2-((hydroxyimino)methyl)-1-methylpyridin-1-ium methanesulfonate
InChi Key
WWZYJJGFUIAWNW-UHFFFAOYSA-N
InChi Code
InChI=1S/C7H8N2O.CH4O3S/c1-9-5-3-2-4-7(9)6-8-10;1-5(2,3)4/h2-6H,1H3;1H3,(H,2,3,4)
SMILES Code
C[n+]1c(/C=N/O)cccc1.CS(=O)([O-])=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 0.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ozawa A. Pralidoxime. Chudoku Kenkyu. 2016 Dec;29(4):371-377. English, Japanese. PMID: 30461237. 2: Walton EL. Pralidoxime and pesticide poisoning: A question of severity? Biomed J. 2016 Dec;39(6):373-375. doi: 10.1016/j.bj.2016.12.001. PMID: 28043415; PMCID: PMC6138517. 3: Quail MT, Shannon MW. Pralidoxime safety and toxicity in children. Prehosp Emerg Care. 2007 Jan-Mar;11(1):36-41. doi: 10.1080/10903120601023289. PMID: 17169874. 4: Jung YH, Mamadjonov N, Lee HY, Jeung KW, Lee BK, Youn CS, Heo T, Min YI. Effects of Different Doses of Pralidoxime Administered During Cardiopulmonary Resuscitation and the Role of α-Adrenergic Receptors in Its Pressor Action. J Am Heart Assoc. 2020 Mar 3;9(5):e015076. doi: 10.1161/JAHA.119.015076. Epub 2020 Feb 19. PMID: 32070203; PMCID: PMC7335542. 5: Eddleston M, Eyer P, Worek F, Juszczak E, Alder N, Mohamed F, Senarathna L, Hittarage A, Azher S, Jeganathan K, Jayamanne S, von Meyer L, Dawson AH, Sheriff MH, Buckley NA. Pralidoxime in acute organophosphorus insecticide poisoning--a randomised controlled trial. PLoS Med. 2009 Jun 30;6(6):e1000104. doi: 10.1371/journal.pmed.1000104. Epub 2009 Jun 30. PMID: 19564902; PMCID: PMC2696321. 6: Jung YH, Lee HY, Jeung KW, Lee BK, Youn CS, Yun SW, Heo T, Min YI. Pralidoxime administered during cardiopulmonary resuscitation facilitates successful resuscitation in a pig model of cardiac arrest. Clin Exp Pharmacol Physiol. 2020 Feb;47(2):236-246. doi: 10.1111/1440-1681.13198. Epub 2019 Nov 17. PMID: 31631356. 7: Eyer P, Buckley N. Pralidoxime for organophosphate poisoning. Lancet. 2006 Dec 16;368(9553):2110-1. doi: 10.1016/S0140-6736(06)69843-7. PMID: 17174692; PMCID: PMC1978066. 8: Lee HY, Mamadjonov N, Jeung KW, Jung YH, Lee BK, Moon KS, Heo T, Min YI. Pralidoxime-Induced Potentiation of the Pressor Effect of Adrenaline and Hastened Successful Resuscitation by Pralidoxime in a Porcine Cardiac Arrest Model. Cardiovasc Drugs Ther. 2020 Oct;34(5):619-628. doi: 10.1007/s10557-020-07026-5. Epub 2020 Jun 19. PMID: 32562104. 9: Abbara C, Rousseau JM, Lelièvre B, Turcant A, Lallement G, Ferec S, Bardot I, Diquet B. Pharmacokinetic analysis of pralidoxime after its intramuscular injection alone or in combination with atropine-avizafone in healthy volunteers. Br J Pharmacol. 2010 Dec;161(8):1857-67. doi: 10.1111/j.1476-5381.2010.01007.x. PMID: 20804498; PMCID: PMC3010588. 10: Holland P, Parkes DC, White RG. Pralidoxime mesylate absorption and heart rate response to atropine sulphate following intramuscular administration of solution mixtures. Br J Clin Pharmacol. 1975 Aug;2(4):333-8. doi: 10.1111/j.1365-2125.1975.tb02780.x. PMID: 788732; PMCID: PMC1402609.

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