AZD5248 | CAS#1254318-44-9 | DPP1 inhibitor

MedKoo Cat#: 465322 | Name: AZD5248

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AZD-5248 is a potent, selective, first generation, oral inhibitor of dipeptidyl peptidase 1 (DPP1).

Chemical Structure

AZD5248

CAS#1254318-44-9

Theoretical Analysis

MedKoo Cat#: 465322

Name: AZD5248

CAS#: 1254318-44-9

Chemical Formula: C22H22N4O2

Exact Mass: 374.1743

Molecular Weight: 374.44

Elemental Analysis: C, 70.57; H, 5.92; N, 14.96; O, 8.55

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

AZD5248; AZD 5248; AZD-5248;

IUPAC/Chemical Name

(S)-4-amino-N-(1-cyano-2-(4'-cyano-[1,1'-biphenyl]-4-yl)ethyl)tetrahydro-2H-pyran-4-carboxamide

InChi Key

NNUFRZJZOXVZIT-FQEVSTJZSA-N

InChi Code

InChI=1S/C22H22N4O2/c23-14-17-3-7-19(8-4-17)18-5-1-16(2-6-18)13-20(15-24)26-21(27)22(25)9-11-28-12-10-22/h1-8,20H,9-13,25H2,(H,26,27)/t20-/m0/s1

SMILES Code

NC1(C(N[C@H](C#N)CC2=CC=C(C3=CC=C(C#N)C=C3)C=C2)=O)CCOCC1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 374.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Banerjee A, Velagaleti R, Patil S, Pawar M, Yadav P, Kadam P, Qadri MM, Chakraborti S, Saini JS, Behera DB, Karanjai K, Iyer PS, Gharat LA, Das S. Development of potent and selective Cathepsin C inhibitors free of aortic binding liability by application of a conformational restriction strategy. Bioorg Med Chem Lett. 2021 Sep 1;47:128202. doi: 10.1016/j.bmcl.2021.128202. Epub 2021 Jun 15. PMID: 34139325. 2: Kingston L, Gu C, Guo J, Swallow S, Elmore CS. The impact of radiochemistry in drug projects: The use of C-14 label in the AZD8529, AZD7325, and AZD6280 projects. J Labelled Comp Radiopharm. 2021 Feb;64(2):65-72. doi: 10.1002/jlcr.3902. Epub 2021 Jan 7. PMID: 33326121. 3: Allen P, Bragg RA, Caffrey M, Ericsson C, Hickey MJ, Kingston LP, Elmore CS. The synthesis of a tritium, carbon-14, and stable isotope-labeled cathepsin C inhibitors. J Labelled Comp Radiopharm. 2017 Feb;60(2):124-129. doi: 10.1002/jlcr.3483. Epub 2016 Dec 21. PMID: 27868229. 4: Bragg RA, Brocklehurst S, Gustafsson F, Goodman J, Hickling K, MacFaul PA, Swallow S, Tugwood J. Aortic Binding of AZD5248: Mechanistic Insight and Reactivity Assays To Support Lead Optimzation. Chem Res Toxicol. 2015 Oct 19;28(10):1991-9. doi: 10.1021/acs.chemrestox.5b00236. Epub 2015 Sep 16. PMID: 26351880.