Metolazone-d7 | CAS#unknown | Metolazone internal standard

MedKoo Cat#: 465319 | Name: Metolazone-d7

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Metolazone-d7 is intended for use as an internal standard for the quantification of metolazone by GC- or LC-MS. Metolazone is a thiazide-like diuretic. It inhibits the Na+/Cl- cotransporter (IC50 = 0.3 µM for the rat transporter) and human carbonic anhydrase VII (CAVII), CAXII, and CAXIII (Kis = 2.1, 5.4, and 15 nM, respectively). Metolazone (0.3 and 1 mg/kg) induces fluid loss and enhances captopril-induced decreases in blood pressure in spontaneously hypertensive rats.3 Formulations containing metolazone have been used in the treatment of high blood pressure.

Chemical Structure

Metolazone-d7

CAS#unknown

Theoretical Analysis

MedKoo Cat#: 465319

Name: Metolazone-d7

CAS#: unknown

Chemical Formula: C16H9D7ClN3O3S

Exact Mass: 372.1040

Molecular Weight: 372.87

Elemental Analysis: C, 51.54; H, 6.21; Cl, 9.51; N, 11.27; O, 12.87; S, 8.60

Price and Availability

Size	Price	Availability	Quantity
1mg	USD 450.00	2 Weeks

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Related CAS #

No Data

Synonym

Metolazone-d7; Metolazone d7; SR 720-22-d7; SR 720-22 d7;

IUPAC/Chemical Name

7-chloro-2-methyl-3-(2-(methyl-d3)phenyl-3,4,5,6-d4)-4-oxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide

InChi Key

AQCHWTWZEMGIFD-HRDWIZOWSA-N

InChi Code

InChI=1S/C16H16ClN3O3S/c1-9-5-3-4-6-14(9)20-10(2)19-13-8-12(17)15(24(18,22)23)7-11(13)16(20)21/h3-8,10,19H,1-2H3,(H2,18,22,23)/i1D3,3D,4D,5D,6D

SMILES Code

O=C1C2=C(NC(N1C3=C(C([2H])=C(C([2H])=C3C([2H])([2H])[2H])[2H])[2H])C)C=C(C(S(N)(=O)=O)=C2)Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 372.87 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Baranauskiene L, Škiudaitė L, Michailovienė V, Petrauskas V, Matulis D. Thiazide and other Cl-benzenesulfonamide-bearing clinical drug affinities for human carbonic anhydrases. PLoS One. 2021 Jun 24;16(6):e0253608. doi: 10.1371/journal.pone.0253608. PMID: 34166457; PMCID: PMC8224972. 2: Garg N, Pekmezaris R, Stevens G, Becerra AZ, Kozikowski A, Patel V, Haddad G, Levy P, Kumar P, Becker L. Performance of Emergency Heart Failure Mortality Risk Grade in the Emergency Department. West J Emerg Med. 2021 Apr 8;22(3):672-677. doi: 10.5811/westjem.2021.1.48978. PMID: 34125045; PMCID: PMC8203016. 3: Bond G, Adnan G, Dua A, Singh K, Crew CM. Metolazone. 2021 May 2. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan–. PMID: 30480942. 4: Orso D, Tavazzi G, Corradi F, Mearelli F, Federici N, Peric D, D'Andrea N, Santori G, Mojoli F, Forfori F, Vetrugno L, Bove T. Comparison of diuretic strategies in diuretic-resistant acute heart failure: a systematic review and network meta-analysis. Eur Rev Med Pharmacol Sci. 2021 Apr;25(7):2971-2980. doi: 10.26355/eurrev_202104_25550. PMID: 33877660. 5: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006–. Metolazone. 2021 Jan 18. PMID: 30000088. 6: Ito A, Zhao Q, Tanaka Y, Yasui M, Katayama R, Sun S, Tanimoto Y, Nishikawa Y, Kage-Nakadai E. Metolazone upregulates mitochondrial chaperones and extends lifespan in Caenorhabditis elegans. Biogerontology. 2021 Feb;22(1):119-131. doi: 10.1007/s10522-020-09907-6. Epub 2020 Nov 20. PMID: 33216250. 7: Steuber TD, Janzen KM, Howard ML. A Systematic Review and Meta-Analysis of Metolazone Compared to Chlorothiazide for Treatment of Acute Decompensated Heart Failure. Pharmacotherapy. 2020 Sep;40(9):924-935. doi: 10.1002/phar.2440. Epub 2020 Aug 7. PMID: 32639593. 8: Drugs for hypertension. Med Lett Drugs Ther. 2020 May 18;62(1598):73-80. PMID: 32555118. 9: Bassi V, Fattoruso O. The Role of Fractional Excretion of Uric Acid in the Differential Diagnosis of Hypotonic Hyponatraemia in Patients with Diuretic Therapy. Cureus. 2020 Apr 21;12(4):e7762. doi: 10.7759/cureus.7762. PMID: 32455079; PMCID: PMC7243088. 10: Srivastava S, Kemnic T, Hildebrandt KR. BRASH syndrome. BMJ Case Rep. 2020 Feb 23;13(2):e233825. doi: 10.1136/bcr-2019-233825. PMID: 32094236; PMCID: PMC7046371. 11: Zaazaa HE, Abdel-Ghany R, Abdelkawy M, Sayed M. Development and Validation of Two Robust Stability-Indicating Chromatographic Methods for Determination of Metolazone in Drug Substance and Pharmaceutical Dosage Form in the Presence of Its Degradation Products and Characterization of Main Degradation Products Based on LC-MS. J Chromatogr Sci. 2020 Apr 22;58(3):251-261. doi: 10.1093/chromsci/bmz110. PMID: 31879759. 12: Salahudin M, Shah H, Jan MU, Altaf A. Comparing the sodium excreting efficacy of furosemide and indapamide combination against furosemide and metolazone combination in congestive heart failure patients: A randomized control trial. J Pak Med Assoc. 2019 Dec;69(12):1794-1799. doi: 10.5455/JPMA.3401. PMID: 31853105. 13: Cox ZL, Hung R, Lenihan DJ, Testani JM. Diuretic Strategies for Loop Diuretic Resistance in Acute Heart Failure: The 3T Trial. JACC Heart Fail. 2020 Mar;8(3):157-168. doi: 10.1016/j.jchf.2019.09.012. Epub 2019 Dec 11. PMID: 31838029; PMCID: PMC7058489. 14: Bohn BC, Hadgu RM, Pope HE, Shuster JE. Oral Metolazone Versus Intravenous Chlorothiazide as an Adjunct to Loop Diuretics for Diuresis in Acute Decompensated Heart Failure With Reduced Ejection Fraction. Hosp Pharm. 2019 Dec;54(6):351-357. doi: 10.1177/0018578718795855. Epub 2018 Aug 30. PMID: 31762481; PMCID: PMC6852027. 15: Filippone EJ, Ruzieh M, Foy A. Thiazide-Associated Hyponatremia: Clinical Manifestations and Pathophysiology. 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PMID: 30371181; PMCID: PMC6222930. 19: Mallappallil MC, Fishbane S, Wanchoo R, Lerma E, Roche-Recinos A, Salifu M. Practice patterns in transitioning patients from chronic kidney disease to dialysis: a survey of United States nephrologists. BMC Nephrol. 2018 Jun 22;19(1):147. doi: 10.1186/s12882-018-0943-0. PMID: 29929485; PMCID: PMC6013940. 20: Liu Y, Goldfarb DS, El-Achkar TM, Lieske JC, Wu XR. Tamm-Horsfall protein/uromodulin deficiency elicits tubular compensatory responses leading to hypertension and hyperuricemia. Am J Physiol Renal Physiol. 2018 Jun 1;314(6):F1062-F1076. doi: 10.1152/ajprenal.00233.2017. Epub 2018 Jan 10. PMID: 29357410; PMCID: PMC6032075.