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MedKoo Cat#: 465316 | Name: Asp-Phe
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

L-Aspartyl-L-phenylalanine is a dipeptide inhibitor of angiotensin-converting enzyme (ACE) and a metabolite of the synthetic non-caloric sweetener aspartame. It is formed from aspartame by intestinal intracellular esterases. L-Aspartyl-L-phenylalanine inhibits ACE with a Ki value of 11 µM for the rabbit enzyme. Serum levels of L-aspartyl-L-phenylalanine are positively associated with pancreatic ductal adenocarcinoma.

Chemical Structure

Asp-Phe
Asp-Phe
CAS#13433-09-5

Theoretical Analysis

MedKoo Cat#: 465316

Name: Asp-Phe

CAS#: 13433-09-5

Chemical Formula: C13H16N2O5

Exact Mass: 280.1059

Molecular Weight: 280.28

Elemental Analysis: C, 55.71; H, 5.75; N, 10.00; O, 28.54

Price and Availability

Size Price Availability Quantity
250mg USD 250.00 2 Weeks
500mg USD 400.00 2 Weeks
1g USD 650.00 2 Weeks
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Related CAS #
No Data
Synonym
Asp-Phe; Asp Phe; AspPhe; L-Aspartyl-L-phenylalanine; α-Aspartylphenylalanine; α Aspartylphenylalanine; H-Asp-Phe-OH
IUPAC/Chemical Name
(S)-3-amino-4-(((S)-1-carboxy-2-phenylethyl)amino)-4-oxobutanoic acid
InChi Key
YZQCXOFQZKCETR-UWVGGRQHSA-N
InChi Code
InChI=1S/C13H16N2O5/c14-9(7-11(16)17)12(18)15-10(13(19)20)6-8-4-2-1-3-5-8/h1-5,9-10H,6-7,14H2,(H,15,18)(H,16,17)(H,19,20)/t9-,10-/m0/s1
SMILES Code
OC(C[C@@H](C(N[C@@H](CC1=CC=CC=C1)C(O)=O)=O)N)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM
Solubility
DMSO 5.0 17.84
DMSO:PBS (pH 7.2) (1:2) 0.3 1.07
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 280.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006–. Aspartame. 2021 Mar 17. PMID: 30000570. 2: Yokozeki K, Abe I. A novel route for aspartame production by combining enzymatic and chemical reactions for industrial use. Biosci Biotechnol Biochem. 2021 Feb 18;85(2):464-466. doi: 10.1093/bbb/zbaa045. PMID: 33604621. 3: Çadirci K, Özdemir Tozlu Ö, Türkez H, Mardinoğlu A. The in vitro cytotoxic, genotoxic, and oxidative damage potentials of the oral artificial sweetener aspartame on cultured human blood cells. Turk J Med Sci. 2020 Apr 9;50(2):448-454. doi: 10.3906/sag-2001-113. PMID: 32222132; PMCID: PMC7164759. 4: Amin SN, Hassan SS, Rashed LA. Effects of chronic aspartame consumption on MPTP-induced Parkinsonism in male and female mice. Arch Physiol Biochem. 2018 Oct;124(4):292-299. doi: 10.1080/13813455.2017.1396348. Epub 2017 Nov 2. PMID: 29096532. 5: Li J, Xie XW, Zhou H, Wang B, Zhang MJ, Tang FY. Metabolic profiling reveals new serum biomarkers of lupus nephritis. Lupus. 2017 Oct;26(11):1166-1173. doi: 10.1177/0961203317694256. Epub 2017 Mar 8. PMID: 28420061. 6: Mahnam K, Raisi F. A theoretical and experimental study of calcium, iron, zinc, cadmium, and sodium ions absorption by aspartame. J Biol Phys. 2017 Mar;43(1):87-103. doi: 10.1007/s10867-016-9435-2. Epub 2017 Feb 1. PMID: 28150114; PMCID: PMC5323347. 7: Toniolo C, Temussi P. Conformational flexibility of aspartame. Biopolymers. 2016 May;106(3):376-84. doi: 10.1002/bip.22847. PMID: 27038223. 8: Prokic MD, Paunovic MG, Matic MM, Djordjevic NZ, Ognjanovic BI, Stajn AS, Saicic ZS. Prooxidative effects of aspartame on antioxidant defense status in erythrocytes of rats. J Biosci. 2014 Dec;39(5):859-66. doi: 10.1007/s12038-014-9487-z. PMID: 25431414. 9: Kim MJ, Yang HJ, Kim JH, Ahn CW, Lee JH, Kim KS, Kwon DY. Obesity-related metabolomic analysis of human subjects in black soybean peptide intervention study by ultraperformance liquid chromatography and quadrupole-time-of-flight mass spectrometry. J Obes. 2013;2013:874981. doi: 10.1155/2013/874981. Epub 2013 Jun 4. PMID: 23862058; PMCID: PMC3686146. 10: Arai T, Noguchi A, Takano E, Kino K. Application of protein N-terminal amidase in enzymatic synthesis of dipeptides containing acidic amino acids specifically at the N-terminus. J Biosci Bioeng. 2013 Apr;115(4):382-7. doi: 10.1016/j.jbiosc.2012.10.024. Epub 2012 Dec 4. PMID: 23218487. 11: Menach E, Yasukawa K, Inouye K. Effects of site-directed mutagenesis of Asn116 in the β-hairpin of the N-terminal domain of thermolysin on its activity and stability. J Biochem. 2012 Sep;152(3):231-9. doi: 10.1093/jb/mvs064. Epub 2012 May 29. PMID: 22648563. 12: Arima J, Kono M, Kita M, Mori N. A mutant leucine aminopeptidase from Streptomyces cinnamoneus with enhanced L-aspartyl L-amino acid methyl ester synthetic activity. Biotechnol Lett. 2012 Jun;34(6):1093-9. doi: 10.1007/s10529-012-0877-8. Epub 2012 Feb 22. PMID: 22354473. 13: Menach E, Yasukawa K, Inouye K. Effects of site-directed mutagenesis of the loop residue of the N-terminal domain Gly117 of thermolysin on its catalytic activity. Biosci Biotechnol Biochem. 2010;74(12):2457-62. doi: 10.1271/bbb.100536. Epub 2010 Dec 7. PMID: 21150094. 14: Kira I, Asano Y, Yokozeki K. Screening, purification, and identification of the enzyme producing N-(L-alpha-L-aspartyl)-L-phenylalanine methyl ester from l-isoasparagine and L-phenylalanine methyl ester. J Biosci Bioeng. 2009 Sep;108(3):190-3. doi: 10.1016/j.jbiosc.2009.03.018. PMID: 19664550. 15: Yagasaki M, Hashimoto S. Synthesis and application of dipeptides; current status and perspectives. Appl Microbiol Biotechnol. 2008 Nov;81(1):13-22. doi: 10.1007/s00253-008-1590-3. Epub 2008 Sep 16. PMID: 18795289. 16: Isono Y, Fukushima K, Kawakatsu T, Nakajima M. Integration of charged membrane into perstraction system for separation of amino acid derivatives. Biotechnol Bioeng. 1997 Oct 20;56(2):162-7. doi: 10.1002/(SICI)1097-0290(19971020)56:2<162::AID-BIT5>3.0.CO;2-N. PMID: 18636621. 17: Guguta C, Meekes H, de Gelder R. The hydration/dehydration behavior of aspartame revisited. J Pharm Biomed Anal. 2008 Mar 13;46(4):617-24. doi: 10.1016/j.jpba.2007.11.044. Epub 2007 Dec 3. PMID: 18207687. 18: Bergstrom BP, Cummings DR, Skaggs TA. Aspartame decreases evoked extracellular dopamine levels in the rat brain: an in vivo voltammetry study. Neuropharmacology. 2007 Dec;53(8):967-74. doi: 10.1016/j.neuropharm.2007.09.009. Epub 2007 Sep 29. PMID: 17976663. 19: Yasukawa K, Inouye K. Improving the activity and stability of thermolysin by site-directed mutagenesis. Biochim Biophys Acta. 2007 Oct;1774(10):1281-8. doi: 10.1016/j.bbapap.2007.08.002. Epub 2007 Aug 14. PMID: 17869197. 20: Yasukawa K, Kusano M, Inouye K. A new method for the extracellular production of recombinant thermolysin by co-expressing the mature sequence and pro-sequence in Escherichia coli. Protein Eng Des Sel. 2007 Aug;20(8):375-83. doi: 10.1093/protein/gzm031. Epub 2007 Jul 6. PMID: 17616558.

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