Synonym
Oxyfedrine; Oxifedrina; Oxyfedrinum
IUPAC/Chemical Name
1-Propanone, 3-((2-hydroxy-1-methyl-2-phenylethyl)amino)-1-(3-methoxyphenyl)-, (R-(R*,S*))-
InChi Key
GDYUVHBMFVMBAF-LIRRHRJNSA-N
InChi Code
InChI=1S/C19H23NO3/c1-14(19(22)15-7-4-3-5-8-15)20-12-11-18(21)16-9-6-10-17(13-16)23-2/h3-10,13-14,19-20,22H,11-12H2,1-2H3/t14-,19-/m0/s1
SMILES Code
O=C(C1=CC=CC(OC)=C1)CCN[C@@H](C)[C@H](O)C2=CC=CC=C2
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
313.39
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Oxyfedrine. Lancet. 1981 Jan 3;1(8210):25-6. PMID: 6109057.
2: Otsuki Y, Yamasaki J, Suina K, Okazaki S, Koike N, Saya H, Nagano O. Vasodilator oxyfedrine inhibits aldehyde metabolism and thereby sensitizes cancer cells to xCT-targeted therapy. Cancer Sci. 2020 Jan;111(1):127-136. doi: 10.1111/cas.14224. Epub 2019 Nov 22. PMID: 31692172; PMCID: PMC6942438.
3: Hahn N, Raqué B, Holst A, Henn I, von Randow H, Malotki D, Oehr P, Felix R. Die Wirkung von Oxyfedrin auf Hämodynamik, Inotropie und Durchblutung des partiell ischämiegeschädigten Myokards nach Prämedikation mit Digoxin. Untersuchungen am narkotisierten Hund [The action of oxyfedrine on haemodynamics, inotropism and blood perfusion of the partially ischaemic myocardium after digoxin premedication. Studies on anaesthetized dogs (author's transl)]. Arzneimittelforschung. 1981;31(3):410-4. German. PMID: 7194664.
4: Sternitzke N, Schieffer H, Rettig G, Bette L. Zum Wirkmechanismus von Oxyfedrin als partieller Betarezeptorenagonist [Mechanism of action of oxyfedrine as a partial beta receptor agonist]. Z Kardiol. 1984 Sep;73(9):586-93. German. PMID: 6095552.
5: Parratt JR. The haemodynamic effects of prolonged oral administration of oxyfedrine, a partial agonist at beta-adrenoceptors: comparison with propranolol. Br J Pharmacol. 1974 May;51(1):5-13. doi: 10.1111/j.1476-5381.1974.tb09625.x. PMID: 4155336; PMCID: PMC1776796.
6: Osswald W, Branco D. The lipolytic action of oxyfedrine in the dog. Pharmacology. 1971;5(3):145-52. doi: 10.1159/000136186. PMID: 5119003.
7: Appel E, Planz G, Palm D, Grobecker H, Stratmann D, Donike M. Excretion of norephedrine by man after oral administration of oxyfedrine. Eur J Clin Pharmacol. 1975 Apr 4;8(3-4):161-6. doi: 10.1007/BF00567109. PMID: 1233214.
8: Sakai K, Shiraki Y, Hashimoto K. An analysis of the B-adrenergic action of oxyfedrine. Eur J Pharmacol. 1973 Jan;21(1):81-8. doi: 10.1016/0014-2999(73)90210-0. PMID: 4145385.
9: Wetzelsberger N, Birkel M, Fuder H, Lücker PW, Stiegler S, Scheithauer S, Thümmler D. Relative bioavailability of DL-oxyfedrine HCl after single-dose oral administration of tablets as compared to equimolar solutions. Methods Find Exp Clin Pharmacol. 1995 Apr;17(3):185-91. PMID: 8531509.
10: Mackenzie JE, Parratt JR. Effects of oxyfedrine on isolated portal vein and other smooth muscles. Br J Pharmacol. 1973 Apr;47(4):827-37. doi: 10.1111/j.1476-5381.1973.tb08210.x. PMID: 4146743; PMCID: PMC1776074.
