MedKoo Cat#: 465309 | Name: Piracetam-d6
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Piracetam-d6 is intended for use as an internal standard for the quantification of piracetam by GC- or LC-MS. Piracetam is a nootropic cyclic GABA derivative. It is a positive allosteric modulator of AMPA receptors and enhances binding of the NMDA antagonist MK-801 to rat forebrain membranes. Piracetam (1 mM) protects against amyloid-β-induced decreases in the mitochondrial membrane potential, as well as decreases in neurite outgrowth in the presence of NGF, in PC12 rat adrenal medulla cells. It prevents scopolamine-induced amnesia in a passive avoidance test in mice when administered at a dose of 30 mg/kg. Formulations containing piracetam have been used in the treatment of myoclonus.

Chemical Structure

Piracetam-d6
Piracetam-d6
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 465309

Name: Piracetam-d6

CAS#: unknown

Chemical Formula: C6H4D6N2O2

Exact Mass: 148.1119

Molecular Weight: 148.19

Elemental Analysis: C, 48.63; H, 10.88; N, 18.90; O, 21.59

Price and Availability

Size Price Availability Quantity
1mg USD 550.00 2 Weeks
5mg USD 1,350.00 2 Weeks
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Related CAS #
No Data
Synonym
Piracetam-d6; Piracetam d6;
IUPAC/Chemical Name
2-(2-oxopyrrolidin-1-yl-3,3,4,4,5,5-d6)acetamide
InChi Key
GMZVRMREEHBGGF-NMFSSPJFSA-N
InChi Code
InChI=1S/C6H10N2O2/c7-5(9)4-8-3-1-2-6(8)10/h1-4H2,(H2,7,9)/i1D2,2D2,3D2
SMILES Code
NC(CN1C(C([2H])(C([2H])(C1([2H])[2H])[2H])[2H])=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 148.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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PMID: 30295186; PMCID: PMC6302556. 12: Patsalos PN, Spencer EP, Berry DJ. Therapeutic Drug Monitoring of Antiepileptic Drugs in Epilepsy: A 2018 Update. Ther Drug Monit. 2018 Oct;40(5):526-548. doi: 10.1097/FTD.0000000000000546. PMID: 29957667. 13: Greenhalgh J, Weston J, Dundar Y, Nevitt SJ, Marson AG. Antiepileptic drugs as prophylaxis for postcraniotomy seizures. Cochrane Database Syst Rev. 2018 May 23;5(5):CD007286. doi: 10.1002/14651858.CD007286.pub4. Update in: Cochrane Database Syst Rev. 2020 Apr 28;4:CD007286. PMID: 29791030; PMCID: PMC6494638. 14: Watkins AK, Gee ME, Brown JN. Efficacy and safety of levetiracetam for migraine prophylaxis: A systematic review. J Clin Pharm Ther. 2018 Aug;43(4):467-475. doi: 10.1111/jcpt.12715. Epub 2018 May 20. PMID: 29781197. 15: Liu S, Wang L, Cai XT, Zhou H, Yu D, Wang Z. Therapeutic benefits of ACTH and levetiracetam in STXBP1 encephalopathy with a de novo mutation: A case report and literature review. Medicine (Baltimore). 2018 May;97(18):e0663. doi: 10.1097/MD.0000000000010663. PMID: 29718889; PMCID: PMC6392729. 16: Bakr A, Belli A. A systematic review of levetiracetam versus phenytoin in the prevention of late post-traumatic seizures and survey of UK neurosurgical prescribing practice of antiepileptic medication in acute traumatic brain injury. Br J Neurosurg. 2018 Jun;32(3):237-244. doi: 10.1080/02688697.2018.1464118. Epub 2018 Apr 24. PMID: 29688078. 17: Zaccara G, Giorgi FS, Amantini A, Giannasi G, Campostrini R, Giovannelli F, Paganini M, Nazerian P; Tuscany study group on seizures in the emergency department and status epilepticus in adults. Why we prefer levetiracetam over phenytoin for treatment of status epilepticus. Acta Neurol Scand. 2018 Jun;137(6):618-622. doi: 10.1111/ane.12928. Epub 2018 Apr 6. PMID: 29624640. 18: Jamroz W, Kurek M, Lyszczarz E, Brniak W, Jachowicz R. PRINTING TECHNIQUES: RECENT DEVELOPMENTS IN PHARMACEUTICAL TECHNOLOGY. Acta Pol Pharm. 2017 May;74(3):753-763. PMID: 29513944. 19: Stockburger C, Eckert S, Eckert GP, Friedland K, Müller WE. Mitochondrial Function, Dynamics, and Permeability Transition: A Complex Love Triangle as A Possible Target for the Treatment of Brain Aging and Alzheimer's Disease. J Alzheimers Dis. 2018;64(s1):S455-S467. doi: 10.3233/JAD-179915. PMID: 29504539. 20: Łukawski K, Andres-Mach M, Czuczwar M, Łuszczki JJ, Kruszyński K, Czuczwar SJ. Mechanisms of epileptogenesis and preclinical approach to antiepileptogenic therapies. Pharmacol Rep. 2018 Apr;70(2):284-293. doi: 10.1016/j.pharep.2017.07.012. Epub 2017 Jul 16. PMID: 29477036.