VU0365114 is a positive allosteric modulator of M5 muscarinic acetylcholine receptors (mAChRs). It increases ACh-induced calcium mobilization in CHO cells expressing human M5 mAChRs (EC50 = 2.7 µM) selectively over CHO cells expressing human M1-4 mAChRs (EC50s = >30 µM for all).
MedKoo Cat#: 465306
Name: VU0365114
CAS#: 1208222-39-2
Chemical Formula: C22H14F3NO3
Exact Mass: 397.0926
Molecular Weight: 397.35
Elemental Analysis: C, 66.50; H, 3.55; F, 14.34; N, 3.53; O, 12.08
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| Ethanol | 10.0 | 25.17 | |
| DMSO | 30.0 | 75.50 | |
| DMF | 30.0 | 75.50 |
The following data is based on the product molecular weight 397.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
