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MedKoo Cat#: 414663 | Name: Oxophenarsine Free Base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Oxophenarsine Free Base is an obsolete toxic arsenical for treatment of syphilis; useful against some neoplasms.

Chemical Structure

Oxophenarsine Free Base
Oxophenarsine Free Base
CAS#306-12-7 (free base)

Theoretical Analysis

MedKoo Cat#: 414663

Name: Oxophenarsine Free Base

CAS#: 306-12-7 (free base)

Chemical Formula: C6H6AsNO2

Exact Mass: 198.9614

Molecular Weight: 199.04

Elemental Analysis: C, 36.21; H, 3.04; As, 37.64; N, 7.04; O, 16.08

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
306-12-7 (free base); 538-03-4 (HCl)
Synonym
Oxophenarsine Free Base; NSC135784; NSC-135784; NSC 135784
IUPAC/Chemical Name
2-amino-4-(oxoarsanyl)phenol
InChi Key
KVGGQNNGLOIZSK-UHFFFAOYSA-N
InChi Code
InChI=1S/C6H6AsNO2/c8-5-3-4(7-10)1-2-6(5)9/h1-3,9H,8H2
SMILES Code
Nc1c(O)ccc([As]=O)c1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 199.04 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Gupta P, Balachandran R, Thampatty P, Rinaldo C, Ho M. Oxophenarsine, an antisyphilis drug inhibits HIV-1-specific protein synthesis in acutely and persistently infected lymphocytes. AIDS Res Hum Retroviruses. 1990 Dec;6(12):1417-23. doi: 10.1089/aid.1990.6.1417. PMID: 2078419. 2: LEONARD CS. Influence of oxophenarsine on hypoglycemic action of insulin. Proc Soc Exp Biol Med. 1948 Jan;67(1):89-92. doi: 10.3181/00379727-67-16214. PMID: 18902303. 3: KOLMER JA. Penicillin in the treatment of experimental syphilis of rabbits. VII. Penicillin "S-R" and procaine penicillin G in peanut oil with aluminum monostearate, alone and in combination with oxophenarsine hydrochloride (mapharsen) or bismuth subsalicylate. AMA Arch Derm Syphilol. 1951 Aug;64(2):169-76. doi: 10.1001/archderm.1951.01570080053008. PMID: 14856407. 4: KNOCK FE. NEWER ANTICANCER AGENTS. Med Clin North Am. 1964 Mar;48:501-27. doi: 10.1016/s0025-7125(16)33478-2. PMID: 14151253. 5: HYMAN AB. Oxophenarsine hydrochloride in treatment of lupus erythematosus. Arch Derm Syphilol. 1946 Jan;53:26-30. doi: 10.1001/archderm.1946.01510300029006. PMID: 21013470. 6: "Found: A One Day Cure for Syphilis". JAMA. 2017 Sep 5;318(9):871. doi: 10.1001/jama.2017.10226. PMID: 28873151. 7: ALEXANDER LJ, SCHOCH AG. Prevention of syphilis; penicillin calcium in oil and white wax, U.S. P., bismuth ethylcamphorate and oxophenarsine hydrochloride in treatment, during incubation stage, of persons exposed to syphilis. Arch Derm Syphilol. 1949 Jan;59(1):1-10. doi: 10.1001/archderm.1949.01520260005001. PMID: 18110552. 8: GREEN RA, KILLICK F. An oxygen-cylinder carrier. Lancet. 1954 Dec 18;267(6851):1266. doi: 10.1016/s0140-6736(54)92055-3. PMID: 13213179. 9: Ott KJ, Stauber LA. Eperythrozoon coccoides: influence on course of infection of Plasmodium chabaudi in mouse. Science. 1967 Mar 24;155(3769):1546-8. doi: 10.1126/science.155.3769.1546. PMID: 6020473. 10: CANTRELL W. The effect of oxophenarsine on the phosphate metabolism of Trypanosoma equiperdum in the rat. J Infect Dis. 1954 Jul-Aug;95(1):92-7. doi: 10.1093/infdis/95.1.92. PMID: 13184170.