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MedKoo Cat#: 465287 | Name: YHN90076
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

YHN90076 is a flavonol glycoside that has been found in C. tricuspidata and A. pilosa and has diverse biological activities. It scavenges DPPH radicals (IC50 = 51.09 μM) and inhibits acetylcholinesterase (AChE) activity (IC50 = 63.94 μM) in cell-free assays. YHN90076 inhibits LPS-induced IL-1β, IL-6, and TNF-α production in mouse RAW 264.7 macrophages in a concentration-dependent manner. It also inhibits the proliferation of human HeLa cervical, K562 leukemia, and A431 epidermoid carcinoma cells (EC50s = 3.9, 3.9, and 14.8 μg/ml, respectively). This product has no formal name. For the convenience of scientific communication, we named it by combining its InChi Key (3 letters from the first letter of each section) with the last 5 digit of its CAS#) according to MedKoo Chemical Nomenclature (https://www.medkoo.com/page/naming).

Chemical Structure

YHN90076
YHN90076
CAS#16290-07-6

Theoretical Analysis

MedKoo Cat#: 465287

Name: YHN90076

CAS#: 16290-07-6

Chemical Formula: C21H20O11

Exact Mass: 448.1006

Molecular Weight: 448.38

Elemental Analysis: C, 56.25; H, 4.50; O, 39.25

Price and Availability

Size Price Availability Quantity
1mg USD 500.00 2 Weeks
5mg USD 1,250.00 2 Weeks
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Related CAS #
No Data
Synonym
YHN90076; YHN 90076; YHN-90076; Kaempferol 7-O-glucoside;
IUPAC/Chemical Name
3,5-dihydroxy-2-(4-hydroxyphenyl)-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one
InChi Key
YPWHZCPMOQGCDQ-HMGRVEAOSA-N
InChi Code
InChI=1S/C21H20O11/c22-7-13-15(25)17(27)19(29)21(32-13)30-10-5-11(24)14-12(6-10)31-20(18(28)16(14)26)8-1-3-9(23)4-2-8/h1-6,13,15,17,19,21-25,27-29H,7H2/t13-,15-,17+,19-,21-/m1/s1
SMILES Code
O=C1C2=C(C=C(C=C2OC(C3=CC=C(O)C=C3)=C1O)O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 448.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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PMID: 30581531; PMCID: PMC6276458. 7: Kyriacou MC, El-Nakhel C, Graziani G, Pannico A, Soteriou GA, Giordano M, Ritieni A, De Pascale S, Rouphael Y. Functional quality in novel food sources: Genotypic variation in the nutritive and phytochemical composition of thirteen microgreens species. Food Chem. 2019 Mar 30;277:107-118. doi: 10.1016/j.foodchem.2018.10.098. Epub 2018 Oct 22. PMID: 30502125. 8: Nishina A, Sato D, Yamamoto J, Kobayashi-Hattori K, Hirai Y, Kimura H. Antidiabetic-Like Effects of Naringenin-7-O-glucoside from Edible Chrysanthemum 'Kotobuki' and Naringenin by Activation of the PI3K/Akt Pathway and PPARγ. Chem Biodivers. 2019 Jan;16(1):e1800434. doi: 10.1002/cbdv.201800434. Epub 2018 Dec 10. PMID: 30462381. 9: Sut S, Dall'Acqua S, Poloniato G, Maggi F, Malagoli M. Preliminary evaluation of quince (Cydonia oblonga Mill.) fruit as extraction source of antioxidant phytoconstituents for nutraceutical and functional food applications. J Sci Food Agric. 2019 Feb;99(3):1046-1054. doi: 10.1002/jsfa.9271. Epub 2018 Oct 4. PMID: 30014572. 10: Wang J, Fang X, Ge L, Cao F, Zhao L, Wang Z, Xiao W. Antitumor, antioxidant and anti-inflammatory activities of kaempferol and its corresponding glycosides and the enzymatic preparation of kaempferol. PLoS One. 2018 May 17;13(5):e0197563. doi: 10.1371/journal.pone.0197563. PMID: 29771951; PMCID: PMC5957424. 11: Wan H, Yu C, Han Y, Guo X, Ahmad S, Tang A, Wang J, Cheng T, Pan H, Zhang Q. Flavonols and Carotenoids in Yellow Petals of Rose Cultivar ( Rosa 'Sun City'): A Possible Rich Source of Bioactive Compounds. J Agric Food Chem. 2018 Apr 25;66(16):4171-4181. doi: 10.1021/acs.jafc.8b01509. Epub 2018 Apr 11. PMID: 29618209. 12: Liu X, Lin C, Ma X, Tan Y, Wang J, Zeng M. Functional Characterization of a Flavonoid Glycosyltransferase in Sweet Orange (Citrus sinensis). Front Plant Sci. 2018 Feb 15;9:166. doi: 10.3389/fpls.2018.00166. PMID: 29497429; PMCID: PMC5818429. 13: Zhu M, Liu T, Zhang C, Guo M. Flavonoids of Lotus (Nelumbo nucifera) Seed Embryos and Their Antioxidant Potential. J Food Sci. 2017 Aug;82(8):1834-1841. doi: 10.1111/1750-3841.13784. Epub 2017 Jun 20. PMID: 28631810. 14: Popova AV, Hincha DK. Effects of flavonol glycosides on liposome stability during freezing and drying. Biochim Biophys Acta. 2016 Dec;1858(12):3050-3060. doi: 10.1016/j.bbamem.2016.09.020. Epub 2016 Sep 24. PMID: 27677212. 15: Behbahani M, Sayedipour S, Pourazar A, Shanehsazzadeh M. In vitro anti-HIV-1 activities of kaempferol and kaempferol-7-O-glucoside isolated from Securigera securidaca. Res Pharm Sci. 2014 Nov-Dec;9(6):463-9. PMID: 26339261; PMCID: PMC4326984. 16: Tofighi Z, Molazem M, Doostdar B, Taban P, Shahverdi AR, Samadi N, Yassa N. Antimicrobial Activities of Three Medicinal Plants and Investigation of Flavonoids of Tripleurospermum disciforme. Iran J Pharm Res. 2015 Winter;14(1):225-31. PMID: 25561928; PMCID: PMC4277635. 17: Louaar S, Achouri A, Lefahal M, Laouer H, Medjroubi K, Duddeck H, Akkal S. Flavonoids from Algerian endemic Centaurea microcarpa and their chemotaxonomical significance. Nat Prod Commun. 2011 Nov;6(11):1603-4. PMID: 22224272. 18: Kami D, Kasuga J, Arakawa K, Fujikawa S. Improved cryopreservation by diluted vitrification solution with supercooling-facilitating flavonol glycoside. Cryobiology. 2008 Dec;57(3):242-5. doi: 10.1016/j.cryobiol.2008.09.003. Epub 2008 Sep 15. PMID: 18824164. 19: Li YL, Gan GP, Zhang HZ, Wu HZ, Li CL, Huang YP, Liu YW, Liu JW. A flavonoid glycoside isolated from Smilax china L. rhizome in vitro anticancer effects on human cancer cell lines. J Ethnopharmacol. 2007 Aug 15;113(1):115-24. doi: 10.1016/j.jep.2007.05.016. Epub 2007 May 18. PMID: 17606345. 20: Rojas S, Macías M, Castañeda P, Bye R, Linares E, Mata R. A new lanostane- type triterpenoid from Chamaesyce prostrata. 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EHT-6706

EHT-6706