MedKoo Cat#: 465282 | Name: Norfluoxetine-d5 HCl
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Norfluoxetine-d5 is intended for use as an internal standard for the quantification of norfluoxetine by GC- or LC-MS. Norfluoxetine is an active metabolite of the antidepressant fluoxetine. It is formed from fluoxetine by the cytochrome P450 (CYP) isoforms CYP2C9, CYP2C19, and CYP3A. Norfluoxetine inhibits serotonin (5-HT) uptake in rat brain synaptosomal membrane preparations (Ki = 44.7 nM) and isolated human platelets (IC50 = ~15 nM). It has been found in the tissues of fish exposed to wastewater effluent.

Chemical Structure

Norfluoxetine-d5 HCl
Norfluoxetine-d5 HCl
CAS#1185132-92-6

Theoretical Analysis

MedKoo Cat#: 465282

Name: Norfluoxetine-d5 HCl

CAS#: 1185132-92-6

Chemical Formula: C16H12D5ClF3NO

Exact Mass: 336.1265

Molecular Weight: 336.79

Elemental Analysis: C, 57.06; H, 6.58; Cl, 10.53; F, 16.92; N, 4.16; O, 4.75

Price and Availability

Size Price Availability Quantity
1mg USD 360.00 2 Weeks
5mg USD 960.00 2 Weeks
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Synonym
Norfluoxetine-d5 HCl; Norfluoxetine d5 HCl; Norfluoxetine-d5 hydrochloride; Norfluoxetine d5 hydrochloride; Desmethylfluoxetine-d5; Desmethylfluoxetine d5;
IUPAC/Chemical Name
3-phenyl-3-(4-(trifluoromethyl)phenoxy)propan-1,1,2,2,3-d5-1-amine hydrochloride
InChi Key
GMTWWEPBGGXBTO-KDPCSTGBSA-N
InChi Code
InChI=1S/C16H16F3NO.ClH/c17-16(18,19)13-6-8-14(9-7-13)21-15(10-11-20)12-4-2-1-3-5-12;/h1-9,15H,10-11,20H2;1H/i10D2,11D2,15D;
SMILES Code
FC(F)(C1=CC=C(OC([2H])(C([2H])(C([2H])(N)[2H])[2H])C2=CC=CC=C2)C=C1)F.Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 336.79 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zahir M, Shariatzadeh S, Khosravi A, Alshaikh FA, Moradi P, Ghaderi M, Farsinejad P, Louyeh PA, Ilkhani S, Nakhaei P, Taheri A, Fagheh AF, Akhavan- Sigari R. High risk of drug toxicity in social isolation stress due to liver dysfunction: Role of oxidative stress and inflammation. Brain Behav. 2021 Aug 1. doi: 10.1002/brb3.2317. Epub ahead of print. PMID: 34333854. 2: Short B. A TREK inhibitor takes multiple tracks. J Gen Physiol. 2021 Aug 2;153(8):e202112986. doi: 10.1085/jgp.202112986. Epub 2021 Jul 7. PMID: 34232275; PMCID: PMC8266558. 3: Atzei A, Jense I, Zwart EP, Legradi J, Venhuis BJ, van der Ven LTM, Heusinkveld HJ, Hessel EVS. Developmental Neurotoxicity of Environmentally Relevant Pharmaceuticals and Mixtures Thereof in a Zebrafish Embryo Behavioural Test. Int J Environ Res Public Health. 2021 Jun 22;18(13):6717. doi: 10.3390/ijerph18136717. PMID: 34206423; PMCID: PMC8297305. 4: Jeong HC, Chae YJ, Lee S, Kang W, Yun HY, Shin KH. Prediction of Fluoxetine and Norfluoxetine Pharmacokinetic Profiles Using Physiologically Based Pharmacokinetic Modeling. J Clin Pharmacol. 2021 Jun 12. doi: 10.1002/jcph.1927. Epub ahead of print. PMID: 34118174. 5: Walsh Y, Leach M, Veale EL, Mathie A. Block of TREK and TRESK K2P channels by lamotrigine and two derivatives sipatrigine and CEN-092. Biochem Biophys Rep. 2021 May 19;26:101021. doi: 10.1016/j.bbrep.2021.101021. PMID: 34041373; PMCID: PMC8144350. 6: Proks P, Schewe M, Conrad LJ, Rao S, Rathje K, Rödström KEJ, Carpenter EP, Baukrowitz T, Tucker SJ. Norfluoxetine inhibits TREK-2 K2P channels by multiple mechanisms including state-independent effects on the selectivity filter gate. J Gen Physiol. 2021 Aug 2;153(8):e202012812. doi: 10.1085/jgp.202012812. Epub 2021 May 25. PMID: 34032848; PMCID: PMC8155809. 7: Cui F, Zhu Y, Di S, Wang X, Zhang Y, Chai T. Toxicological Study on Chiral Fluoxetine Exposure to Adult Zebrafish (Danio rerio): Enantioselective and Sexual Mechanism on Disruption of the Brain Serotonergic System. Environ Sci Technol. 2021 Jun 1;55(11):7479-7490. doi: 10.1021/acs.est.1c01397. Epub 2021 May 18. PMID: 34002605. 8: Woods CB, Spencer KA, Jung S, Worstman HM, Ramirez JM, Morgan PG, Sedensky MM. Mitochondrial Function and Anesthetic Sensitivity in the Mouse Spinal Cord. Anesthesiology. 2021 Jun 1;134(6):901-914. doi: 10.1097/ALN.0000000000003794. PMID: 33909880; PMCID: PMC8119385. 9: Ma W, Gao X, Guo H, Chen W. Determination of 13 antidepressants in blood by UPLC-MS/MS with supported liquid extraction pretreatment. J Chromatogr B Analyt Technol Biomed Life Sci. 2021 May 1;1171:122608. doi: 10.1016/j.jchromb.2021.122608. Epub 2021 Mar 1. PMID: 33756452. 10: Duarte Y, Rojas M, Canan J, Pérez EG, González-Nilo F, García-Colunga J. Different Classes of Antidepressants Inhibit the Rat α7 Nicotinic Acetylcholine Receptor by Interacting within the Ion Channel: A Functional and Structural Study. Molecules. 2021 Feb 13;26(4):998. doi: 10.3390/molecules26040998. PMID: 33668529; PMCID: PMC7918632. 11: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006–. Fluoxetine. 2021 Feb 15. PMID: 30000245. 12: Deodhar M, Rihani SBA, Darakjian L, Turgeon J, Michaud V. Assessing the Mechanism of Fluoxetine-Mediated CYP2D6 Inhibition. Pharmaceutics. 2021 Jan 23;13(2):148. doi: 10.3390/pharmaceutics13020148. PMID: 33498694; PMCID: PMC7912198. 13: Chai T, Cui F, Di S, Wu S, Zhang Y, Wang X. New insights into cardiotoxicity induced by chiral fluoxetine at environmental-level: Enantioselective arrhythmia in developmental zebrafish (Danio rerio). Environ Pollut. 2021 Feb 1;270:116182. doi: 10.1016/j.envpol.2020.116182. Epub 2020 Dec 5. PMID: 33352483. 14: Rodrigues P, Cunha V, Oliva-Teles L, Ferreira M, Guimarães L. Effects of norfluoxetine and venlafaxine in zebrafish larvae: Molecular data. Data Brief. 2020 Nov 10;33:106515. doi: 10.1016/j.dib.2020.106515. PMID: 33294513; PMCID: PMC7689041. 15: Li D, Xiong X, Zhuang S, Du Z, Xiong C, Jiang H. Preparation of bovine serum albumin restricted access octadecyl/phenyl-mixed-functionalized magnetic silica nanoparticles for magnetic solid phase extraction of antidepressants in aquatic products followed by UHPLC-MS/MS. Talanta. 2021 Jan 1;221:121458. doi: 10.1016/j.talanta.2020.121458. Epub 2020 Jul 30. PMID: 33076080. 16: Över SB, Güven C, Taskin E, Sevgiler Y. Oxidative and apoptotic effects of fluoxetine and its metabolite norfluoxetine in Daphnia magna. Arh Hig Rada Toksikol. 2020 Oct 6;71(3):211-222. doi: 10.2478/aiht-2020-71-3473. PMID: 33074175; PMCID: PMC7968500. 17: Rodrigues TB, Morais DR, Gianvecchio VAP, Aquino EM, Cunha RL, Huestis MA, Costa JL. Development and Validation of a Method for Quantification of 28 Psychotropic Drugs in Postmortem Blood Samples by Modified Micro-QuEChERS and LC-MS-MS. J Anal Toxicol. 2020 Sep 30:bkaa138. doi: 10.1093/jat/bkaa138. Epub ahead of print. PMID: 32991709. 18: Kosma CI, Kapsi MG, Konstas PG, Trantopoulos EP, Boti VI, Konstantinou IK, Albanis TA. Assessment of multiclass pharmaceutical active compounds (PhACs) in hospital WWTP influent and effluent samples by UHPLC-Orbitrap MS: Temporal variation, removals and environmental risk assessment. Environ Res. 2020 Dec;191:110152. doi: 10.1016/j.envres.2020.110152. Epub 2020 Aug 30. PMID: 32877707; PMCID: PMC7456450. 19: Zindler F, Stoll S, Baumann L, Knoll S, Huhn C, Braunbeck T. Do environmentally relevant concentrations of fluoxetine and citalopram impair stress-related behavior in zebrafish (Danio rerio) embryos? Chemosphere. 2020 Dec;261:127753. doi: 10.1016/j.chemosphere.2020.127753. Epub 2020 Jul 23. PMID: 32745739. 20: Wang Q, Chen Z, Chen D, Luo S, Xie L. Simultaneous quantification of vortioxetine, fluoxetine and their metabolites in rat plasma by UPLC-MS/MS. Biomed Chromatogr. 2020 Dec;34(12):e4960. doi: 10.1002/bmc.4960. Epub 2020 Aug 13. PMID: 32729624.