CC-90005 is a potent and selective small-molecule inhibitor of protein kinase C-theta (PKC-θ), exhibiting an IC₅₀ of 8 nM. It demonstrates remarkable selectivity over PKC-δ, with an IC₅₀ of 4,440 nM, indicating over 500-fold preference for PKC-θ. Preclinical studies have shown that CC-90005 effectively inhibits T cell activation by suppressing IL-2 expression, positioning it as a promising candidate for therapeutic applications in T cell-mediated autoimmune diseases.
MedKoo Cat#: 465273
Name: CC90005
CAS#: 1799574-70-1
Chemical Formula: C21H27F2N7O2
Exact Mass: 447.2194
Molecular Weight: 447.49
Elemental Analysis: C, 56.37; H, 6.08; F, 8.49; N, 21.91; O, 7.15
The following data is based on the product molecular weight 447.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
