Rocuronium Free Base | CAS# 143558-00-3 (free base) | androstanol non-depolarizing neuromuscular blocking agent

MedKoo Cat#: 414624 | Name: Rocuronium Free Base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Rocuronium Free Base is an androstanol non-depolarizing neuromuscular blocking agent. It has a mono-quaternary structure and is a weaker nicotinic antagonist than PANCURONIUM.

Chemical Structure

Rocuronium Free Base

CAS#143558-00-3 (free base)

Theoretical Analysis

MedKoo Cat#: 414624

Name: Rocuronium Free Base

CAS#: 143558-00-3 (free base)

Chemical Formula: C32H53N2O4+

Exact Mass: 529.4000

Molecular Weight: 529.79

Elemental Analysis: C, 72.55; H, 10.08; N, 5.29; O, 12.08

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

143558-00-3 (free base); 119302-91-9 (bromide)

Synonym

Rocuronium Free Base; ORG9426; ORG-9426; ORG 9426

IUPAC/Chemical Name

1-((2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-17-acetoxy-3-hydroxy-10,13-dimethyl-2-morpholinohexadecahydro-1H-cyclopenta[a]phenanthren-16-yl)-1-allylpyrrolidin-1-ium

InChi Key

YXRDKMPIGHSVRX-OOJCLDBCSA-N

InChi Code

InChI=1S/C32H53N2O4/c1-5-14-34(15-6-7-16-34)28-20-26-24-9-8-23-19-29(36)27(33-12-17-37-18-13-33)21-32(23,4)25(24)10-11-31(26,3)30(28)38-22(2)35/h5,23-30,36H,1,6-21H2,2-4H3/q+1/t23-,24+,25-,26-,27-,28-,29-,30-,31-,32-/m0/s1

SMILES Code

CC(O[C@H]1[C@@H]([N+]2(CCCC2)CC=C)C[C@H]3[C@@H]4CC[C@H]5C[C@@H]([C@@H](N6CCOCC6)C[C@@]5([C@H]4CC[C@]13C)C)O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 529.79 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Guihard B, Chollet-Xémard C, Lakhnati P, Vivien B, Broche C, Savary D, Ricard-Hibon A, Marianne Dit Cassou PJ, Adnet F, Wiel E, Deutsch J, Tissier C, Loeb T, Bounes V, Rousseau E, Jabre P, Huiart L, Ferdynus C, Combes X. Effect of Rocuronium vs Succinylcholine on Endotracheal Intubation Success Rate Among Patients Undergoing Out-of-Hospital Rapid Sequence Intubation: A Randomized Clinical Trial. JAMA. 2019 Dec 17;322(23):2303-2312. doi: 10.1001/jama.2019.18254. PMID: 31846014; PMCID: PMC6990819. 2: Tran DTT, Newton EK, Mount VAH, Lee JS, Mansour C, Wells GA, Perry JJ. Rocuronium vs. succinylcholine for rapid sequence intubation: a Cochrane systematic review. Anaesthesia. 2017 Jun;72(6):765-777. doi: 10.1111/anae.13903. PMID: 28654173. 3: Liu XW, Gong RS, Liu Z, Zuo J, Zhao J. [Neuromuscular Pharmacodynamics of Rocuronium in Diabetic Rats]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2019 Apr 28;41(2):149-155. Chinese. doi: 10.3881/j.issn.1000-503X.11169. PMID: 31060667. 4: Swaminathan AK, Mallemat H. Rocuronium Should Be the Default Paralytic in Rapid Sequence Intubation. Ann Emerg Med. 2018 Mar;71(3):397-398. doi: 10.1016/j.annemergmed.2017.04.039. Epub 2017 Jun 23. PMID: 28601274. 5: Murata Y, Kawamoto S, Fukuda K. Rocuronium Has a Suppressive Effect on Platelet Function via the P2Y12 Receptor Pathway In Vitro That Is Not Reversed by Sugammadex. Int J Mol Sci. 2020 Sep 3;21(17):6399. doi: 10.3390/ijms21176399. PMID: 32899133; PMCID: PMC7504164. 6: Bebawy JF. Rocuronium bromide. Anesthesiology. 2011 Jun;114(6):1486. doi: 10.1097/ALN.0b013e3181fe3cea. PMID: 21263302. 7: Long CS, Miller MR, McMullin GM, Tivey SL. Transesophageal Echocardiography- Guided Cardiopulmonary Resuscitation After Rocuronium Anaphylaxis. A A Pract. 2020 Apr;14(6):e01175. doi: 10.1213/XAA.0000000000001175. PMID: 32132360. 8: Couto M, Nunes C, Vide S, Amorim P, Mendes J. Rocuronium Continuous Infusion for Profound Neuromuscular Blockade: A Systematic Review and Meta-analysis. Clin Neuropharmacol. 2019 Nov/Dec;42(6):203-210. doi: 10.1097/WNF.0000000000000366. PMID: 31725475. 9: Tachikawa M, Asai T, Okuda Y. Rocuronium Bromide Intravenous Solution Maruishi® is more suitable than ESLAX Intravenous® during rapid-sequence induction of anesthesia. J Anesth. 2019 Oct;33(5):600-603. doi: 10.1007/s00540-019-02673-x. Epub 2019 Aug 21. PMID: 31435739. 10: Zhu XY, Xue FS, Shao LJ, Li XL. Comparing Succinylcholine and Rocuronium for Emergency Intubation. Ann Emerg Med. 2019 May;73(5):548-549. doi: 10.1016/j.annemergmed.2018.12.003. PMID: 31029292.