Org 7797 | CAS# 80177-51-1 | orally active antifibrillatory agent

MedKoo Cat#: 414620 | Name: Org 7797

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Org 7797 is an orally active antifibrillatory agent, devoid of cardio-depressant and CNS activities, and is well tolerated.

Chemical Structure

Org 7797

CAS#80177-51-1

Theoretical Analysis

MedKoo Cat#: 414620

Name: Org 7797

CAS#: 80177-51-1

Chemical Formula: C23H31NO6

Exact Mass: 417.2151

Molecular Weight: 417.50

Elemental Analysis: C, 66.17; H, 7.48; N, 3.35; O, 22.99

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Org 7797; Org7797; Org-7797

IUPAC/Chemical Name

(3,16alpha-Dihydroxyestra-1,3,5(10)-trien-17beta-yl)(methyl)ammonium hydrogen maleate

InChi Key

UDCGSEPMGRJOAG-IQQQYFTASA-N

InChi Code

InChI=1S/C19H27NO2.C4H4O4/c1-19-8-7-14-13-6-4-12(21)9-11(13)3-5-15(14)16(19)10-17(22)18(19)20-2;5-3(6)1-2-4(7)8/h4,6,9,14-18,20-22H,3,5,7-8,10H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t14-,15-,16+,17-,18+,19+;/m1./s1

SMILES Code

C[NH2+][C@H]1[C@H](O)C[C@@]2([H])[C@]3([H])CCC4=C(C=CC(O)=C4)[C@@]3([H])CC[C@]12C.O=C(O)/C=C\C([O-])=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 417.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Leboeuf J, Basiez M, Massingham R. Electrophysiological effects of Org 7797 in the closed-chest anaesthetized dog. Br J Pharmacol. 1993 Sep;110(1):23-8. doi: 10.1111/j.1476-5381.1993.tb13766.x. PMID: 8220882; PMCID: PMC2176014. 2: Winslow E, Mason R. Comparative hemodynamic effects of Org 7797, flecainide, and propafenone in anesthetized pigs with developing myocardial infarcts. J Cardiovasc Pharmacol. 1992 Mar;19(3):435-41. doi: 10.1097/00005344-199203000-00021. PMID: 1378126. 3: Winslow E, Campbell JK, Barron E, Marshall RJ, Muir AW. Effects of Org 7797 on early, late and inducible arrhythmias following coronary artery occlusion in rats and dogs. Br J Pharmacol. 1991 Dec;104(4):853-8. doi: 10.1111/j.1476-5381.1991.tb12517.x. PMID: 1810599; PMCID: PMC1908862. 4: Kirchhof C, Wijffels M, Brugada J, Planellas J, Allessie M. Mode of action of a new class IC drug (ORG 7797) against atrial fibrillation in conscious dogs. J Cardiovasc Pharmacol. 1991 Jan;17(1):116-24. doi: 10.1097/00005344-199101000-00017. PMID: 1708044. 5: Delbressine L, Harris N, Kane KA, Muir AW, Winslow E. Antiarrhythmic, electrophysiological and haemodynamic effects of prolonged oral dosing with Org 7797 in the anaesthetized rat. J Pharm Pharmacol. 1992 Dec;44(12):996-1000. doi: 10.1111/j.2042-7158.1992.tb07081.x. PMID: 1361566. 6: Winslow E, Martorana M, Bell P. Electrophysiologic effects of Org 7797, a new steroidal antiarrhythmic agent: comparison with class 1a, 1b, and 1c drugs. J Cardiovasc Pharmacol. 1989 Aug;14(2):205-12. doi: 10.1097/00005344-198908000-00004. PMID: 2476592. 7: Janse MJ, Wilms-Schopman F, Opthof T. Mechanism of antifibrillatory action of Org 7797 in regionally ischemic pig heart. J Cardiovasc Pharmacol. 1990 Apr;15(4):633-43. doi: 10.1097/00005344-199004000-00017. PMID: 1691395. 8: Winslow E, Campbell JK. Comparative frequency-dependent effects of three class Ic agents, Org 7797, flecainide, and propafenone, on ventricular action potential duration. J Cardiovasc Pharmacol. 1991 Dec;18(6):911-7. doi: 10.1097/00005344-199112000-00019. PMID: 1725906. 9: Campbell JK, Marshall RJ, Winslow E. Comparison of the electrophysiological effects of Org 7797, disopyramide, mexiletine and propafenone in anaesthetized dogs with myocardial infarcts. Br J Pharmacol. 1991 Oct;104(2):433-9. doi: 10.1111/j.1476-5381.1991.tb12447.x. PMID: 1797309; PMCID: PMC1908530. 10: Winslow E, Campbell JK, Delbressine L. Antiarrhythmic and electrophysiological effects in-vivo of the major metabolite of Org 7797 found in canine and rodent liver homogenate preparations. J Pharm Pharmacol. 1995 Jul;47(7):608-13. doi: 10.1111/j.2042-7158.1995.tb06723.x. PMID: 8568630.