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MedKoo Cat#: 414618 | Name: ORG 6370

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ORG 6370 is a new antiepileptic drug.

Chemical Structure

ORG 6370
ORG 6370
CAS#103667-44-3

Theoretical Analysis

MedKoo Cat#: 414618

Name: ORG 6370

CAS#: 103667-44-3

Chemical Formula: C15H20ClN

Exact Mass: 249.1284

Molecular Weight: 249.78

Elemental Analysis: C, 72.13; H, 8.07; Cl, 14.19; N, 5.61

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
ORG 6370; ORG6370; ORG-6370
IUPAC/Chemical Name
5,9-Methanobenzocycloocten-11-amine, 5,6,9,10-tetrahydro-N,N-dimethyl-, hydrochloride, (5alpha,9alpha,11S*)-
InChi Key
ZTKAONUXTHAYGD-DWGNNRDYSA-N
InChi Code
InChI=1S/C15H19N.ClH/c1-16(2)15-12-7-5-9-14(15)13-8-4-3-6-11(13)10-12;/h3-8,12,14-15H,9-10H2,1-2H3;1H/t12-,14+,15-;/m0./s1
SMILES Code
CN(C)[C@@H]1[C@]2([H])CC=C[C@@]1([H])CC3=CC=CC=C32.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 249.78 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kasteleijn-Nolst Trenité DG, van Emde Boas W, Groenhout CM, Meinardi H. Preliminary assessment of the efficacy of Org 6370 in photosensitive epileptic patients: paradoxical enhancement of photosensitivity and provocation of myoclonic seizures. Epilepsia. 1992 Jan-Feb;33(1):135-41. doi: 10.1111/j.1528-1157.1992.tb02296.x. PMID: 1733747. 2: Kapetanovic IM, Yonekawa WD, Kupferberg HJ, Cos L, Rollins DE, Tolman KG. Single and multiple dose kinetics of a new antiepileptic drug, Org 6370, and its desmethyl metabolite, Org 6363. Ther Drug Monit. 1986;8(2):140-4. doi: 10.1097/00007691-198606000-00002. PMID: 3726925. 3: Mares P, Mirvaldová H, Bĕlská M. Influence of a new antiepileptic drug ORG 6370 on metrazol-induced seizures in rats during ontogenesis. Physiol Bohemoslov. 1990;39(3):199-205. PMID: 2145597. 4: Fisher R, Blum D. Clobazam, oxcarbazepine, tiagabine, topiramate, and other new antiepileptic drugs. Epilepsia. 1995;36 Suppl 2:S105-14. doi: 10.1111/j.1528-1157.1995.tb05993.x. PMID: 8784219. 5: Yonekawa WD, Kapetanovic IM, Kupferberg HJ, Paanakker JE, van de Laar GL. Determination in plasma of a new antiepileptic drug, dl-(5 alpha,9 alpha,11S*)-5,6,9,10-tetrahydro-N,N-dimethyl-5,9-methanobenzocycloo cten-11-amine hydrochloride, and its N-desmethyl metabolite by liquid-solid extraction and capillary gas chromatography. J Chromatogr. 1986 Apr 25;377:205-12. doi: 10.1016/s0378-4347(00)80775-6. PMID: 3711209.