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MedKoo Cat#: 414611 | Name: Org 24461

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Org 24461 is a synaptic and nonsynaptic glycine transporter type-1 inhibitor.

Chemical Structure

Org 24461
Org 24461
CAS#372198-80-6

Theoretical Analysis

MedKoo Cat#: 414611

Name: Org 24461

CAS#: 372198-80-6

Chemical Formula: C19H20F3NO3

Exact Mass: 367.1395

Molecular Weight: 367.37

Elemental Analysis: C, 62.12; H, 5.49; F, 15.51; N, 3.81; O, 13.07

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Org 24461; Org24461; Org-24461; LY 507311; LY507311; LY-507311
IUPAC/Chemical Name
N-methyl-N-(3-phenyl-3-(4-(trifluoromethyl)phenoxy)propyl)glycine
InChi Key
KZWQAWBTWNPFPW-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H20F3NO3/c1-23(13-18(24)25)12-11-17(14-5-3-2-4-6-14)26-16-9-7-15(8-10-16)19(20,21)22/h2-10,17H,11-13H2,1H3,(H,24,25)
SMILES Code
CN(CC(O)=O)CCC(c1ccccc1)Oc2ccc(C(F)(F)F)cc2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 367.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Harsing LG Jr, Gacsalyi I, Szabo G, Schmidt E, Sziray N, Sebban C, Tesolin- Decros B, Matyus P, Egyed A, Spedding M, Levay G. The glycine transporter-1 inhibitors NFPS and Org 24461: a pharmacological study. Pharmacol Biochem Behav. 2003 Mar;74(4):811-25. doi: 10.1016/s0091-3057(02)01078-x. PMID: 12667895. 2: Kertesz S, Szabo G, Udvari S, Levay G, Matyus P, Harsing LG Jr. Temporal alteration of spreading depression by the glycine transporter type-1 inhibitors NFPS and Org-24461 in chicken retina. Brain Res. 2013 Jan 25;1492:1-6. doi: 10.1016/j.brainres.2012.11.025. Epub 2012 Nov 23. PMID: 23178696. 3: Nagy K, Marko B, Zsilla G, Matyus P, Pallagi K, Szabo G, Juranyi Z, Barkoczy J, Levay G, Harsing LG Jr. Alterations in brain extracellular dopamine and glycine levels following combined administration of the glycine transporter type-1 inhibitor Org-24461 and risperidone. Neurochem Res. 2010 Dec;35(12):2096-106. doi: 10.1007/s11064-010-0241-0. Epub 2010 Aug 20. PMID: 20725779. 4: Harsing LG Jr, Albert M, Matyus P, Szenasi G. Inhibition of hypoxia-induced [(3)H]glycine release from chicken retina by the glycine transporter type-1 (GlyT-1) inhibitors NFPS and Org-24461. Exp Eye Res. 2012 Jan;94(1):6-12. doi: 10.1016/j.exer.2011.10.010. Epub 2011 Nov 9. PMID: 22079563. 5: Papp A, Juranyi Z, Nagymajtenyi L, Matyus P, Harsing LG Jr. The synaptic and nonsynaptic glycine transporter type-1 inhibitors Org-24461 and NFPS alter single neuron firing rate in the rat dorsal raphe nucleus. Further evidence for a glutamatergic-serotonergic interaction and its role in antipsychotic action. Neurochem Int. 2008 Jan;52(1-2):130-4. doi: 10.1016/j.neuint.2007.06.030. Epub 2007 Jul 1. PMID: 17669555. 6: Harsing LG Jr, Juranyi Z, Gacsalyi I, Tapolcsanyi P, Czompa A, Matyus P. Glycine transporter type-1 and its inhibitors. Curr Med Chem. 2006;13(9):1017-44. doi: 10.2174/092986706776360932. PMID: 16611082. 7: Rorick-Kehn LM, Hart JC, McKinzie DL. Pharmacological characterization of stress-induced hyperthermia in DBA/2 mice using metabotropic and ionotropic glutamate receptor ligands. Psychopharmacology (Berl). 2005 Dec;183(2):226-40. doi: 10.1007/s00213-005-0169-2. Epub 2005 Nov 9. PMID: 16175401. 8: Harsing LG Jr, Matyus P. Mechanisms of glycine release, which build up synaptic and extrasynaptic glycine levels: the role of synaptic and non-synaptic glycine transporters. Brain Res Bull. 2013 Apr;93:110-9. doi: 10.1016/j.brainresbull.2012.12.002. Epub 2012 Dec 22. PMID: 23266673. 9: Johnson KW, Clemens-Smith A, Nomikos G, Davis R, Phebus L, Shannon H, Love P, Perry K, Katner J, Bymaster F, Yu H, Hoffman BJ. In vivo characterization of changes in glycine levels induced by GlyT1 inhibitors. Ann N Y Acad Sci. 2003 Nov;1003:412-4. doi: 10.1196/annals.1300.039. PMID: 14684475.