ORG-25435 | CAS# 256456-73-2 | GABAA receptor positive allosteric modulator

MedKoo Cat#: 414610 | Name: ORG-25435

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ORG-25435 is a synthetic drug developed by Organon International, which acts as a GABAA receptor positive allosteric modulator, and produces sedative effects. It has been researched for use as an intravenous anesthetic agent, with positive results in initial trials, although negative side effects like hypotension and tachycardia, as well as unpredictable pharmacokinetics at higher doses, have meant it has ultimately not been adopted for medical use.

Chemical Structure

ORG-25435

CAS#256456-73-2

Theoretical Analysis

MedKoo Cat#: 414610

Name: ORG-25435

CAS#: 256456-73-2

Chemical Formula: C19H31NO6

Exact Mass: 369.2151

Molecular Weight: 369.46

Elemental Analysis: C, 61.77; H, 8.46; N, 3.79; O, 25.98

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

ORG-25435; ORG25435; ORG 25435

IUPAC/Chemical Name

Butanoic acid, 2-(bis(2-methoxyethyl)amino)-, 2,6-dimethoxy-4-methylphenyl ester, (2R)-

InChi Key

GKRFHHRXDUACIN-OAHLLOKOSA-N

InChi Code

InChI=1S/C19H31NO6/c1-7-15(20(8-10-22-3)9-11-23-4)19(21)26-18-16(24-5)12-14(2)13-17(18)25-6/h12-13,15H,7-11H2,1-6H3/t15-/m1/s1

SMILES Code

CC[C@@H](N(CCOC)CCOC)C(OC1=C(OC)C=C(C)C=C1OC)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 369.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Rigby-Jones AE, Sneyd JR, Vijn P, Boen P, Cross M. First administration to man of Org 25435, an intravenous anaesthetic: A Phase 1 Clinical Trial. BMC Anesthesiol. 2010 Jun 29;10:10. doi: 10.1186/1471-2253-10-10. PMID: 20587019; PMCID: PMC2914736. 2: Anderson A, Belelli D, Bennett DJ, Buchanan KI, Casula A, Cooke A, Feilden H, Gemmell DK, Hamilton NM, Hutchinson EJ, Lambert JJ, Maidment MS, McGuire R, McPhail P, Miller S, Muntoni A, Peters JA, Sansbury FH, Stevenson D, Sundaram H. Alpha-amino acid phenolic ester derivatives: novel water-soluble general anesthetic agents which allosterically modulate GABA(A) receptors. J Med Chem. 2001 Oct 25;44(22):3582-91. doi: 10.1021/jm010903i. PMID: 11606122. 3: Kalinichev M, Starr KR, Teague S, Bradford AM, Porter RA, Herdon HJ. Glycine transporter 1 (GlyT1) inhibitors exhibit anticonvulsant properties in the rat maximal electroshock threshold (MEST) test. Brain Res. 2010 May 17;1331:105-13. doi: 10.1016/j.brainres.2010.03.032. Epub 2010 Mar 18. PMID: 20303337.