IUPAC/Chemical Name
(S)-N-(2-(6-((amino(iminio)methyl)amino)-2-ammoniohexanamido)ethyl)-N-methyl-N-octadecyloctadecan-1-aminium chloride
InChi Key
ZZUYVEFGBZXOOI-DYGFFKSMSA-N
InChi Code
InChI=1S/C46H96N6O.3ClH/c1-4-6-8-10-12-14-16-18-20-22-24-26-28-30-32-36-41-52(3,43-40-50-45(53)44(47)38-34-35-39-51-46(48)49)42-37-33-31-29-27-25-23-21-19-17-15-13-11-9-7-5-2;;;/h44H,4-43,47H2,1-3H3,(H4-,48,49,50,51,53);3*1H/t44-;;;/m0.../s1
SMILES Code
NC(NCCCC[C@H]([NH3+])C(NCC[N+](CCCCCCCCCCCCCCCCCC)(C)CCCCCCCCCCCCCCCCCC)=O)=[NH2+].[Cl-].[Cl-].[Cl-]
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
858.69
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Charbe NB, Amnerkar ND, Ramesh B, Tambuwala MM, Bakshi HA, Aljabali AAA, Khadse SC, Satheeshkumar R, Satija S, Metha M, Chellappan DK, Shrivastava G, Gupta G, Negi P, Dua K, Zacconi FC. Small interfering RNA for cancer treatment: overcoming hurdles in delivery. Acta Pharm Sin B. 2020 Nov;10(11):2075-2109. doi: 10.1016/j.apsb.2020.10.005. Epub 2020 Oct 13. PMID: 33304780; PMCID: PMC7714980.
2: Li SD, Huang L. Nanoparticles evading the reticuloendothelial system: role of the supported bilayer. Biochim Biophys Acta. 2009 Oct;1788(10):2259-66. doi: 10.1016/j.bbamem.2009.06.022. Epub 2009 Jul 10. PMID: 19595666; PMCID: PMC2757503.
3: Chen Y, Sen J, Bathula SR, Yang Q, Fittipaldi R, Huang L. Novel cationic lipid that delivers siRNA and enhances therapeutic effect in lung cancer cells. Mol Pharm. 2009 May-Jun;6(3):696-705. doi: 10.1021/mp800136v. PMID: 19267451; PMCID: PMC2763490.
