MedKoo Cat#: 414586 | Name: Sepetaprost

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Sepetaprost is a prodrug of ONO-AG-367. It has been used in trials studying the treatment of Open Angle-glaucoma, Ocular Hypertension, and Mild Open Angle-glaucoma (OAG).

Chemical Structure

Sepetaprost
CAS#1262873-06-2

Theoretical Analysis

MedKoo Cat#: 414586

Name: Sepetaprost

CAS#: 1262873-06-2

Chemical Formula: C26H36F2O6

Exact Mass: 482.2480

Molecular Weight: 482.56

Elemental Analysis: C, 64.71; H, 7.52; F, 7.87; O, 19.89

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Sepetaprost; ONO-9054; ONO9054; ONO 9054
IUPAC/Chemical Name
2H-Cyclopent(b)oxepin-3-butanoic acid, 6-((1E,3R)-4-(2,5-difluorophenoxy)-3-hydroxy-1-buten-1-yl)octahydro-7-hydroxy-, 1-methylethyl ester, (3S,5aR,6R,7R,8aS)-
InChi Key
BKVUSNOUTQMSBE-XCMGCKIWSA-N
InChi Code
InChI=1S/C26H36F2O6/c1-16(2)34-26(31)5-3-4-17-6-9-21-20(23(30)13-24(21)32-14-17)10-8-19(29)15-33-25-12-18(27)7-11-22(25)28/h7-8,10-12,16-17,19-21,23-24,29-30H,3-6,9,13-15H2,1-2H3/b10-8+/t17-,19+,20+,21+,23+,24-/m0/s1
SMILES Code
O=C(OC(C)C)CCC[C@H]1CC[C@@]([C@@H](/C=C/[C@@H](O)COC2=CC(F)=CC=C2F)[C@H](O)C3)([H])[C@@]3([H])OC1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 482.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Impagnatiello F, Bastia E, Almirante N, Brambilla S, Duquesroix B, Kothe AC, Bergamini MVW. Prostaglandin analogues and nitric oxide contribution in the treatment of ocular hypertension and glaucoma. Br J Pharmacol. 2019 Apr;176(8):1079-1089. doi: 10.1111/bph.14328. Epub 2018 May 24. PMID: 29669171; PMCID: PMC6451067.