Related CAS #
87-00-3 (free base); 51-56-9 (HBr)
Synonym
Homatropine Free Base; BRN0087959; BRN-0087959; BRN 0087959
IUPAC/Chemical Name
(1R,3r,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl 2-hydroxy-2-phenylacetate
InChi Key
ZTVIKZXZYLEVOL-MCOXGKPRSA-N
InChi Code
InChI=1S/C16H21NO3/c1-17-12-7-8-13(17)10-14(9-12)20-16(19)15(18)11-5-3-2-4-6-11/h2-6,12-15,18H,7-10H2,1H3/t12-,13+,14+,15?
SMILES Code
CN1[C@@H]2CC[C@H]1C[C@@H](OC(C(c3ccccc3)O)=O)C2
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
275.35
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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2: Sander BP, Collins MJ, Read SA. The interaction between homatropine and optical blur on choroidal thickness. Ophthalmic Physiol Opt. 2018 May;38(3):257-265. doi: 10.1111/opo.12450. PMID: 29691923.
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7: Bhatia J. Effect of tropicamide and homatropine eye drops on a-scan parameters of the phakic normal eyes. Oman Med J. 2011 Jan;26(1):23-5. doi: 10.5001/omj.2011.06. PMID: 22043374; PMCID: PMC3191618.
8: Bryant SM, Wills BK, Rhee JW, Aks SE, Maloney G. Intramuscular ophthalmic homatropine vs. atropine to prevent lethality in rates with dichlorvos poisoning. J Med Toxicol. 2006 Dec;2(4):156-9. doi: 10.1007/BF03161184. PMID: 18072136; PMCID: PMC3550072.
9: Whelan NC, Castillo-Alcala F, Lizarraga I. Efficacy of tropicamide, homatropine, cyclopentolate, atropine and hyoscine as mydriatics in Angora goats. N Z Vet J. 2011 Nov;59(6):328-31. doi: 10.1080/00480169.2011.609476. PMID: 22040340.
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