Olanexidine | CAS# 146510-36-3 | antiseptic/disinfectant compound

MedKoo Cat#: 414559 | Name: Olanexidine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Olanexidine is an antiseptic/disinfectant compound with potent bactericidal activity against Gram-negative and Gram-positive bacteria

Chemical Structure

Olanexidine

CAS#146510-36-3

Theoretical Analysis

MedKoo Cat#: 414559

Name: Olanexidine

CAS#: 146510-36-3

Chemical Formula: C17H27Cl2N5

Exact Mass: 371.1644

Molecular Weight: 372.34

Elemental Analysis: C, 54.84; H, 7.31; Cl, 19.04; N, 18.81

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Olanexidine

IUPAC/Chemical Name

1-(3,4-Dichlorobenzyl)-5-octylbiguanide

InChi Key

ZZQMUJGZCZTLQD-UHFFFAOYSA-N

InChi Code

InChI=1S/C17H27Cl2N5/c1-2-3-4-5-6-7-10-22-16(20)24-17(21)23-12-13-8-9-14(18)15(19)11-13/h8-9,11H,2-7,10,12H2,1H3,(H5,20,21,22,23,24)

SMILES Code

N=C(NC(NCCCCCCCC)=N)NCC1=CC=C(Cl)C(Cl)=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 372.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Obara H, Takeuchi M, Kawakubo H, Shinoda M, Okabayashi K, Hayashi K, Sekimoto Y, Maeda Y, Kondo T, Sato Y, Kitagawa Y. Aqueous olanexidine versus aqueous povidone-iodine for surgical skin antisepsis on the incidence of surgical site infections after clean-contaminated surgery: a multicentre, prospective, blinded-endpoint, randomised controlled trial. Lancet Infect Dis. 2020 Nov;20(11):1281-1289. doi: 10.1016/S1473-3099(20)30225-5. Epub 2020 Jun 15. PMID: 32553191. 2: Willy C, Vogt D. Should olanexidine be used routinely for surgical skin antisepsis? Lancet Infect Dis. 2020 Nov;20(11):1219-1220. doi: 10.1016/S1473-3099(20)30281-4. Epub 2020 Jun 15. PMID: 32553189. 3: Imai K, Hagi A, Inoue Y, Amarasiri M, Sano D. Virucidal Efficacy of Olanexidine Gluconate as a Hand Antiseptic Against Human Norovirus. Food Environ Virol. 2020 Jun;12(2):180-190. doi: 10.1007/s12560-020-09422-4. Epub 2020 Mar 2. PMID: 32124244; PMCID: PMC7225205. 4: Asukai M, Ohishi T, Fujita T, Suzuki D, Nishida T, Sugiura K, Matsuyama Y. Olanexidine gluconate versus povidone-iodine for preventing surgical-site infection in orthopaedic surgery: A retrospective study. J Orthop Sci. 2019 Nov;24(6):1125-1129. doi: 10.1016/j.jos.2019.07.008. Epub 2019 Aug 6. PMID: 31395421. 5: Nakata H, Tsubotani Y, Nii T, Hagi A, Inoue Y, Imamura T. Effects of olanexidine gluconate on preoperative skin preparation: an experimental study in cynomolgus monkeys. J Med Microbiol. 2017 May;66(5):678-685. doi: 10.1099/jmm.0.000462. Epub 2017 May 18. PMID: 28516852; PMCID: PMC5817230. 6: Nii T, Yumoto H, Hirota K, Miyake Y. Anti-inflammatory effects of olanexidine gluconate on oral epithelial cells. BMC Oral Health. 2019 Nov 8;19(1):239. doi: 10.1186/s12903-019-0932-0. PMID: 31703580; PMCID: PMC6839112. 7: Nakaminami H, Takadama S, Okita M, Sasaki M, Noguchi N. Fast-acting bactericidal activity of olanexidine gluconate against qacA/B-positive methicillin-resistant Staphylococcus aureus. J Med Microbiol. 2019 Jun;68(6):957-960. doi: 10.1099/jmm.0.000979. Epub 2019 May 3. PMID: 31050633. 8: Matsuoka K, Kumata S, Watanabe R, Yamada T, Matsuoka T, Nagai S, Ueda M, Miyamoto Y. Dermatitis caused by Olanedine (olanexidine gluconate) and povidone iodine. Contact Dermatitis. 2019 Apr;80(4):239-241. doi: 10.1111/cod.13178. Epub 2018 Dec 13. PMID: 30430595. 9: Hu Y, Xiao Y, Rao Z, Kumar V, Liu H, Lu C. Carbon-Carbon Bond Cleavage Catalyzed by Human Cytochrome P450 Enzymes: a-Ketol as the Key Intermediate Metabolite in Sequential Metabolism of Olanexidine. Drug Metab Lett. 2019 Nov 24. doi: 10.2174/1872312813666191125095818. Epub ahead of print. PMID: 31763971. 10: Takeuchi M, Obara H, Kawakubo H, Shinoda M, Okabayashi K, Mayanagi S, Irino T, Fukuda K, Nakamura R, Wada N, Kitago M, Yagi H, Abe Y, Oshima G, Hori S, Tsuruta M, Ishida T, Yokose T, Hirukawa K, Isobe Y, Sekimoto Y, Harada H, Maeda Y, Shito M, Kondo T, Sato Y, Kitagawa Y. Comparison of olanexidine versus povidone-iodine for preventing surgical site infection in gastrointestinal surgery: study protocol for a multicentre, single-blind, randomised controlled clinical trial. BMJ Open. 2019 May 28;9(5):e028269. doi: 10.1136/bmjopen-2018-028269. PMID: 31142533; PMCID: PMC6549615.