Synonym
MEN10612; MEN 10612; MEN-10612
IUPAC/Chemical Name
3-(11-((1H-indol-3-yl)methyl)-14-benzyl-5-(cyclohexylmethyl)-2-isobutyl-6,9,12,15,19-pentaoxo-1,4,7,10,13,16-hexaazacyclononadecan-8-yl)propanamide
InChi Key
YMJSHBCDXDDCQD-UHFFFAOYSA-N
InChi Code
InChI=1S/C43H60N8O6/c1-27(2)21-31-26-47-35(22-28-11-5-3-6-12-28)42(56)49-34(17-18-38(44)52)41(55)51-37(24-30-25-46-33-16-10-9-15-32(30)33)43(57)50-36(23-29-13-7-4-8-14-29)40(54)45-20-19-39(53)48-31/h4,7-10,13-16,25,27-28,31,34-37,46-47H,3,5-6,11-12,17-24,26H2,1-2H3,(H2,44,52)(H,45,54)(H,48,53)(H,49,56)(H,50,57)(H,51,55)
SMILES Code
CC(C)CC1CNC(CC2CCCCC2)C(=O)NC(CCC(=O)N)C(=O)NC(Cc3c[nH]c4ccccc34)C(=O)NC(Cc5ccccc5)C(=O)NCCC(=O)N1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
785.00
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1. Maggi CA, Quartara L, Patacchini R, Giuliani S, Barbanti G, Turini D, Giachetti A. MEN 10,573 and MEN 10,612, novel cyclic pseudopeptides which are potent tachykinin NK-2 receptor antagonists. Regul Pept. 1993 Sep 3;47(2):151-8. doi: 10.1016/0167-0115(93)90419-9. PMID: 8234901.
2. Patacchini R, Giuliani S, Lazzeri M, Turini A, Quartara L, Maggi CA. Effect of several bicyclic peptide and cyclic pseudopeptide tachykinin NK2 receptor antagonists in the human isolated ileum and colon. Neuropeptides. 1997 Feb;31(1):71-7. doi: 10.1016/s0143-4179(97)90023-8. PMID: 9574841.
3. Quartara L, Fabbri G, Ricci R, Patacchini R, Pestellini V, Maggi CA, Pavone V, Giachetti A, Arcamone F. Influence of lipophilicity on the biological activity of cyclic pseudopeptide NK-2 receptor antagonists. J Med Chem. 1994 Oct 14;37(21):3630-8. doi: 10.1021/jm00047a020. PMID: 7932590.
