Obatoclax free base | CAS# 803712-67-6 | pan-Bcl-2 inhibitor

MedKoo Cat#: 414529 | Name: Obatoclax free base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Obatoclax, also known as GX 015-070, a synthetic small-molecule inhibitor of the bcl-2 family of proteins with potential pro-apoptotic and antineoplastic activities. Obatoclax binds to members of the Bcl-2 protein family, preventing the binding of these anti-apoptotic proteins to the pro-apoptotic proteins Bax and Bak and so promoting the activation of the apoptotic pathway in Bcl-2-overexpressing cells. The Bcl-2 family of proteins (bcl-2, bcl-xl, bcl-w, and Mcl-1) are overexpressed in a wide variety of cancers, including those of the lymphatic system, breast, lung, prostate, and colon.

Chemical Structure

Obatoclax free base

CAS#803712-67-6 (free base)

Theoretical Analysis

MedKoo Cat#: 414529

Name: Obatoclax free base

CAS#: 803712-67-6 (free base)

Chemical Formula: C20H19N3O

Exact Mass: 317.1528

Molecular Weight: 317.39

Elemental Analysis: C, 75.69; H, 6.03; N, 13.24; O, 5.04

Price and Availability

Size	Price	Availability
50mg	USD 550.00	2 Weeks
100mg	USD 950.00	2 Weeks
200mg	USD 1,450.00	2 Weeks
500mg	USD 2,950.00	2 Weeks
1g	USD 4,650.00	2 Weeks
2g	USD 6,950.00	2 Weeks

Bulk Inquiry

Buy Now

Add to Cart

Related CAS #

803712-67-6 (free base); 803712-79-0 (mesylate)

Synonym

Obatoclax Free Base; GX05-070; GX-05-070; GX 05-070; GX15-070; GX 15-070; GX-15-070

IUPAC/Chemical Name

1H-indole, 2-(2-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-3-methoxy-2H-pyrrol-5-yl)-

InChi Key

RFTSSZJZXOSICM-GRSHGNNSSA-N

InChi Code

InChI=1S/C20H19N3O/c1-12-8-13(2)21-16(12)10-19-20(24-3)11-18(23-19)17-9-14-6-4-5-7-15(14)22-17/h4-11,21-22H,1-3H3/b19-10-

SMILES Code

COC1=CC(C(N2)=CC3=C2C=CC=C3)=N/C1=C\C4=C(C)C=C(C)N4

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 317.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Qusa M, Qosa H, Volpe DA. Evaluation of In Vitro Metabolism- and Transporter- Based Drug Interactions with Sunscreen Active Ingredients. Pharm Res. 2024 Jul 24. doi: 10.1007/s11095-024-03746-7. Epub ahead of print. PMID: 39044045. 2: Dos Santos GA, Gomes JVT, da Silva ACP, Dos Santos JL, Bello ML, Santos BAMC. Computer-aided drug design supporting sunscreen research: a showcase study using previously synthesized hybrid UV filter-antioxidant compounds. J Mol Model. 2024 Jul 6;30(8):255. doi: 10.1007/s00894-024-06056-2. PMID: 38970658. 3: Popiół J, Gunia-Krzyżak A, Słoczyńska K, Piska K, Kocot N, Żelaszczyk D, Krupa A, Wójcik-Pszczoła K, Marona H, Pękala E. In vitro safety evaluation of (6-methoxy-9-oxo-9H-xanthen-2-yl)methyl (E)-3-(2,4-dimethoxyphenyl)acrylate (K-116) - the novel potential UV filter designed by means of a double chromophore strategy. Xenobiotica. 2024 Jun 24:1-13. doi: 10.1080/00498254.2024.2363332. Epub ahead of print. PMID: 38819995. 4: Lorigo M, Quintaneiro C, Breitenfeld L, Cairrao E. Exposure to UV-B filter octylmethoxycinnamate and human health effects: Focus on endocrine disruptor actions. Chemosphere. 2024 Jun;358:142218. doi: 10.1016/j.chemosphere.2024.142218. Epub 2024 May 2. PMID: 38704047. 5: Marcellini F, Varrella S, Ghilardi M, Barucca G, Giorgetti A, Danovaro R, Corinaldesi C. Inorganic UV filter-based sunscreens labelled as eco-friendly threaten sea urchin populations. Environ Pollut. 2024 Jun 15;351:124093. doi: 10.1016/j.envpol.2024.124093. Epub 2024 May 2. PMID: 38703981. 6: He J, Chen Z, Jing C, Zhang W, Peng H, Zhou H, Hu F. Behavioral and biochemical responses of the marine polychaete Perinereis aibuhitensis to 2-ethylhexyl-4-methoxycinnamate (EHMC) exposure. Comp Biochem Physiol C Toxicol Pharmacol. 2024 May;279:109868. doi: 10.1016/j.cbpc.2024.109868. Epub 2024 Feb 28. PMID: 38423197. 7: Yang Q, Tian L, Wang W, Chen X, Tao J. Post-fertilization 2-ethylhexyl-4-methoxycinnamate (EHMC) exposure affects axonal growth, muscle fiber length, and motor behavior in zebrafish embryos. Ecotoxicol Environ Saf. 2024 Mar 1;272:116053. doi: 10.1016/j.ecoenv.2024.116053. Epub 2024 Feb 1. PMID: 38306815. 8: Lorigo M, Quintaneiro C, Breitenfeld L, Cairrao E. Effects associated with exposure to the emerging contaminant octyl-methoxycinnamate (a UV-B filter) in the aquatic environment: a review. J Toxicol Environ Health B Crit Rev. 2024 Feb 17;27(2):55-72. doi: 10.1080/10937404.2023.2296897. Epub 2024 Jan 26. PMID: 38146151. 9: Jiang D, Yang G, Huang LJ, Chen K, Tang Y, Pi X, Yang R, Peng X, Cui C, Li N. Unveiling the toxic effects, physiological responses and molecular mechanisms of tobacco (Nicotiana tabacum) in exposure to organic ultraviolet filters. J Hazard Mater. 2024 Mar 5;465:133060. doi: 10.1016/j.jhazmat.2023.133060. Epub 2023 Nov 23. PMID: 38016314. 10: Slabu AI, Miu L, Ghibu E, Stavarache CE, Stan R, Teodorescu F. Bioconjugation of Vegetable Oils with UV Absorbers: New Approach in Skin Photoprotection. Molecules. 2023 Nov 12;28(22):7550. doi: 10.3390/molecules28227550. PMID: 38005272; PMCID: PMC10674893. 11: Hamadeh A, Nash JF, Bialk H, Styczynski P, Troutman J, Edginton A. Mechanistic Skin Modeling of Plasma Concentrations of Sunscreen Active Ingredients Following Facial Application. J Pharm Sci. 2024 Mar;113(3):806-825. doi: 10.1016/j.xphs.2023.09.017. Epub 2023 Sep 26. PMID: 37769994. 12: Liu Y, Gao L, Ai Q, Qiao L, Li J, Lyu B, Zheng M, Wu Y. Concentrations, Profiles, and Health Risks of Organic Ultraviolet Filters in Eight Food Categories Determined through the Sixth Chinese Total Diet Study. Environ Sci Technol. 2023 Sep 12;57(36):13366-13374. doi: 10.1021/acs.est.3c03888. Epub 2023 Aug 30. PMID: 37647541. 13: Onyango DO, Selman BG, Rose JL, Ellison CA, Nash JF. Comparison between endocrine activity assessed using ToxCast/Tox21 database and human plasma concentration of sunscreen active ingredients/UV filters. Toxicol Sci. 2023 Oct 30;196(1):25-37. doi: 10.1093/toxsci/kfad082. PMID: 37561120; PMCID: PMC10613966. 14: Lorigo M, Mangana C, Cairrao E. Disrupting effects of the emerging contaminant octylmethoxycinnamate (OMC) on human umbilical artery relaxation. Environ Pollut. 2023 Oct 15;335:122302. doi: 10.1016/j.envpol.2023.122302. Epub 2023 Aug 1. PMID: 37536478. 15: Brown AK, Farenhorst A. Quantitation of Canadian organic ultraviolet filters using polarity switching and ultra-high performance liquid chromatography-tandem mass spectrometry. J Chromatogr A. 2023 Aug 16;1704:464132. doi: 10.1016/j.chroma.2023.464132. Epub 2023 Jun 4. PMID: 37302251. 16: Lukić J, Đurkić T, Onjia A. Dispersive liquid-liquid microextraction and Monte Carlo simulation of margin of safety for octocrylene, EHMC, 2ES, and homosalate in sunscreens. Biomed Chromatogr. 2023 Apr;37(4):e5590. doi: 10.1002/bmc.5590. Epub 2023 Feb 9. PMID: 36709999. 17: Pantelic MN, Wong N, Kwa M, Lim HW. Ultraviolet filters in the United States and European Union: A review of safety and implications for the future of US sunscreens. J Am Acad Dermatol. 2023 Mar;88(3):632-646. doi: 10.1016/j.jaad.2022.11.039. Epub 2022 Nov 26. PMID: 36442641. 18: Zambrano D, Millán D, Guevara-Pulido J. In silico design, synthesis and evaluation of a less toxic octinoxate alternative with suitable photoprotection properties. Eur J Pharm Sci. 2023 Jan 1;180:106332. doi: 10.1016/j.ejps.2022.106332. Epub 2022 Nov 16. PMID: 36400130. 19: Chang KY, Yang CH, Chou HY, Chen KC, Huang YC. Organic ultraviolet filters regulate hyaluronan metabolism in human epidermal keratinocytes through the phosphatidylinositol 3-kinase pathway. Toxicol In Vitro. 2023 Feb;86:105511. doi: 10.1016/j.tiv.2022.105511. Epub 2022 Nov 4. PMID: 36336209. 20: Adamiano A, Carella F, Degli Esposti L, Piccirillo C, Iafisco M. Calcium Phosphates from Fishery Byproducts as a Booster of the Sun Protection Factor in Sunscreens. ACS Biomater Sci Eng. 2022 Nov 14;8(11):4987-4995. doi: 10.1021/acsbiomaterials.2c00680. Epub 2022 Oct 31. PMID: 36315184.