Uramustine | Uracil Mustard | CAS#66-75-1 | DNA Alkylating Agent

MedKoo Cat#: 100900 | Name: Uramustine

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Uramustine (INN), also known as uracil mustard, is a chemotherapy drug which belongs to the class of alkylating agents. It is used in lymphatic malignancies such as non-Hodgkin's lymphoma. It works by damaging DNA, primarily in cancer cells that preferentially take up the uracil due to their need to make nucleic acids during their rapid cycles of cell division. The DNA damage leads to apoptosis of the affected cells. Bone marrow suppression and nausea are the main side effects. Chemically it is a derivative of nitrogen mustard and uracil.

Chemical Structure

Uramustine

CAS#66-75-1

Theoretical Analysis

MedKoo Cat#: 100900

Name: Uramustine

CAS#: 66-75-1

Chemical Formula: C8H11Cl2N3O2

Exact Mass: 251.0228

Molecular Weight: 252.10

Elemental Analysis: C, 38.11; H, 4.40; Cl, 28.13; N, 16.67; O, 12.69

Price and Availability

Size	Price	Availability
5mg	USD 90.00	Ready to ship
10mg	USD 150.00	Ready to ship
25mg	USD 250.00	Ready to ship
50mg	USD 450.00	Ready to ship
100mg	USD 750.00	Ready to ship
200mg	USD 1,250.00	Ready to ship

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Related CAS #

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Synonym

uracil mustard, Demethyldopan, Desmethyldopan, Uracilmostaza, Uracillost, Uramustin, Nordopan, Chlorethaminacil, Aminouracil mustard, Uramustina, Uramustinum

IUPAC/Chemical Name

5-[bis(2-chloroethyl)amino]-1H-pyrimidine-2,4-dione

InChi Key

IDPUKCWIGUEADI-UHFFFAOYSA-N

InChi Code

InChI=1S/C8H11Cl2N3O2/c9-1-3-13(4-2-10)6-5-11-8(15)12-7(6)14/h5H,1-4H2,(H2,11,12,14,15)

SMILES Code

O=C1NC(C(N(CCCl)CCCl)=CN1)=O

Appearance

White solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Uramustine (INN) or uracil mustard is a chemotherapy drug which belongs to the class of alkylating agents. It is used in lymphatic malignancies such as non-Hodgkin's lymphoma. It works by damaging DNA, primarily in cancer cells that preferentially take up the uracil due to their need to make nucleic acids during their rapid cycles of cell division. The DNA damage leads to apoptosis of the affected cells. Bone marrow suppression and nausea are the main side effects. Chemically it is a derivative of nitrogen mustard and uracil.

Product Data

Product Data

Certificate of Analysis

View CoA: current batch, Lot#KB20823

QC Data

View QC data: current batch, Lot#KB20823

Safety Data Sheet (SDS)

View Safety Data Sheet (SDS)

Instruction

View handling instruction

Biological target:

N/A

In vitro activity:

N/A

In vivo activity:

N/A

Preparing Stock Solutions

The following data is based on the product molecular weight 252.10 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

N/A

In vitro protocol:

N/A

In vivo protocol:

N/A

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