Synonym
Aloxiprin; Oalaprin; Lyman; Rumatral; Superpyrin
IUPAC/Chemical Name
aluminum 2-acetyloxybenzoate hydroxide
InChi Key
MXCPYJZDGPQDRA-UHFFFAOYSA-N
InChi Code
InChI=1S/C9H8O4.2Al.3O/c1-6(10)13-8-5-3-2-4-7(8)9(11)12;;;;;/h2-5H,1H3,(H,11,12);;;;;/q;2*+3;3*-2
SMILES Code
CC(Oc1c(C(O)=O)cccc1)=O.[O-2].[O-2].[O-2].[Al+3].[Al+3]
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
282.12
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Wright MG. Micro-encapsulated aspirin (Levius) compared with aloxiprin (Palaprin Forte) in the treatment of rheumatoid arthritis. J Int Med Res. 1976;4(4):272-5. doi: 10.1177/030006057600400410. PMID: 1026550.
2: CUMMINGS AJ, MARTIN BK, WIGGINS LF. In vitro and in vivo properties of aloxiprin: a new aluminium derivative of acetylsalicylic acid. J Pharm Pharmacol. 1963 Jan;15:56-62. doi: 10.1111/j.2042-7158.1963.tb12743.x. PMID: 14024235.
3: Balme HW, Wojtulewski JA, Huskisson EC. Clinical experience with tolmetin sodium. Curr Med Res Opin. 1980;7(2):127-30. doi: 10.1185/03007998009112039. PMID: 7002482.
4: Price T, Venning H, Ansell BM. Indoprofen in juvenile chronic arthritis. Clin Exp Rheumatol. 1985 Jan-Mar;3(1):59-62. PMID: 3978896.
5: Rowan RM, McDonald GA, Renton RL, Corne SJ, Brown DF. Inhibition of platelet release reaction by acetylsalicylic acid. Postgrad Med J. 1976 Feb;52(604):71-5. doi: 10.1136/pgmj.52.604.71. PMID: 1264926; PMCID: PMC2496292.
6: Vojtisek O, Kanková D, Pavelka K, Hándlová D. Wirkungsvergleich zwischen Niflumsäure und Aloxiprin bei Kranken mit progredient chronischer Polyarthritis im Doppelblindversuch [Comparison of the effects of niflumic acid and aloxiprin in patients with progressive chronic rheumatoid arthritis in a double blind trial]. Arzneimittelforschung. 1975 Aug;25(8):1308-11. German. PMID: 1101907.
7: Huskisson EC, Hart FD. The use of indomethacin and aloxiprin at night. Practitioner. 1972 Feb;208(244):248-51. PMID: 4552566.
8: Roberts SD, Vir C, Porter KG. Once-daily piroxicam in rheumatoid arthritis: a double-blind cross-over comparison with aloxiprin. Eur J Rheumatol Inflamm. 1981;4(3):323-31. PMID: 6086096.
9: Geller J. A comparative trial of aloxiprin ('Palaprin Forte') and phenylbutazone ('Butazolidin'). Br J Clin Pract. 1968 Sep;22(9):392-4. PMID: 4876729.
10: LEVY G, SAHLI BA. Comparison of the gastrointestinal absorption of aluminum acetylsalicylate and acetylsalicylic acid in man. J Pharm Sci. 1962 Jan;51:58-62. doi: 10.1002/jps.2600510110. PMID: 14464762.
