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MedKoo Cat#: 464997 | Name: PKI 14-22 amide,myristoylated TFA
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

PKI 14-22 amide,myristoylated TFA is a cell-permeable peptide inhibitor of protein kinase A (PKA). It inhibits PKA activity in mouse brain or spinal cord lysates when used at a concentration of 75 µM. DUN-01324 reduces IgG-dependent phagocytosis of heat-killed S. cerevisiae by isolated human neutrophils in a concentration-dependent manner. It inhibits the replication of several strains of Zika virus, including IbH 30656, MR766, H/FP/2013, and PRVABC59, in human umbilical vein endothelial cells (HUVECs; IC50s = 17.75, 22.29, 34.09, and 19.19 µM, respectively). DUN-01324 (2.5 nmol, i.c.v.) increases latency to tail withdrawal in the tail-flick test in morphine-tolerant mice. This product has no formal name. For the convenience of scientific communication, we named it by combining its InChi Key (3 letters from the first letter of each section) with the last 5 digit of its CAS#) according to MedKoo Chemical Nomenclature (https://www.medkoo.com/page/naming).

Chemical Structure

PKI 14-22 amide,myristoylated TFA
PKI 14-22 amide,myristoylated TFA
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 464997

Name: PKI 14-22 amide,myristoylated TFA

CAS#: unknown

Chemical Formula: C55H101F3N20O14

Exact Mass:

Molecular Weight: 1323.53

Elemental Analysis: C, 49.91; H, 7.69; F, 4.31; N, 21.17; O, 16.92

Price and Availability

Size Price Availability Quantity
5mg USD 500.00 2 Weeks
10mg USD 850.00 2 Weeks
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Related CAS #
No Data
Synonym
PKI 14-22 amide myristoylated TFA; Myr-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH2; Myr-GRTGRRNAI-NH2; Myristoylated PKI-(14-22)-amide; PKI-(Myr-14-22)-amide;
IUPAC/Chemical Name
(S)-N1-((S)-1-(((2S,3S)-1-amino-3-methyl-1-oxopentan-2-yl)amino)-1-oxopropan-2-yl)-2-((2S,5S,11S,14S)-2,5,14-tris(3-guanidinopropyl)-11-((R)-1-hydroxyethyl)-4,7,10,13,16,19-hexaoxo-3,6,9,12,15,18-hexaazadotriacontanamido)succinamide 2,2,2-trifluoroacetate
InChi Key
DBHNUJXUTKVLID-UXBYPZMDSA-N
InChi Code
InChI=1S/C53H100N20O12.C2HF3O2/c1-6-8-9-10-11-12-13-14-15-16-17-24-39(76)65-29-40(77)69-35(22-19-26-63-52(58)59)48(83)73-43(33(5)74)50(85)66-30-41(78)68-34(21-18-25-62-51(56)57)46(81)70-36(23-20-27-64-53(60)61)47(82)71-37(28-38(54)75)49(84)67-32(4)45(80)72-42(44(55)79)31(3)7-2;3-2(4,5)1(6)7/h31-37,42-43,74H,6-30H2,1-5H3,(H2,54,75)(H2,55,79)(H,65,76)(H,66,85)(H,67,84)(H,68,78)(H,69,77)(H,70,81)(H,71,82)(H,72,80)(H,73,83)(H4,56,57,62)(H4,58,59,63)(H4,60,61,64);(H,6,7)/t31-,32-,33+,34-,35-,36-,37-,42-,43-;/m0./s1
SMILES Code
O=C(NCC(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H]([C@H](CC)C)C(N)=O)=O)C)=O)CC(N)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)=O)[C@@H](C)O)=O)CCCNC(N)=N)=O)CCCCCCCCCCCCC.OC(C(F)(F)F)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM comments
Solubility
DMSO 1.0 0.76
DMSO:PBS (pH 7.2) (1:3) 0.3 0.19
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 1,323.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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