MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 464994 | Name: Isoproterenol-d7 HCl
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Isoproterenol-d7 is intended for use as an internal standard for the quantification of isoproterenol by GC- or LC-MS. Isoproterenol is an agonist of β1- and β2-adrenergic receptors (β1- and β2-ARs; Kis = 224 and 458 nM, respectively). It is selective for β1- and β2-ARs over β3-ARs (Ki = 1,570 nM). Isoproterenol inhibits contractions in isolated field-stimulated rat vas deferens (EC50 = 45.6 nM). In vivo, isoproterenol (0.33 mg/kg) decreases blood pressure and increases water intake in nephrectomized rats. It reduces blood pressure and increases heart rate in renal hypertensive rabbits. Isoproterenol inhibits histamine-induced bronchospasms in anesthetized dogs. Formulations containing isoproterenol have been used in the treatment of bradydysrhythmias and to improve breathing during anesthesia.

Chemical Structure

Isoproterenol-d7 HCl
Isoproterenol-d7 HCl
CAS#2517584-04-0

Theoretical Analysis

MedKoo Cat#: 464994

Name: Isoproterenol-d7 HCl

CAS#: 2517584-04-0

Chemical Formula: C11H11D7ClNO3

Exact Mass: 254.1415

Molecular Weight: 254.76

Elemental Analysis: C, 51.86; H, 9.89; Cl, 13.91; N, 5.50; O, 18.84

Price and Availability

Size Price Availability Quantity
1mg USD 315.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
Isoproterenol-d7 HCl; Isoproterenol d7 HCl; Isoproterenol d7 hydrochloride; Isoproterenol-d7 hydrochloride;
IUPAC/Chemical Name
4-(1-hydroxy-2-((propan-2-yl-d7)amino)ethyl)benzene-1,2-diol hydrochloride
InChi Key
IROWCYIEJAOFOW-AUYCXRIESA-N
InChi Code
InChI=1S/C11H17NO3.ClH/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8;/h3-5,7,11-15H,6H2,1-2H3;1H/i1D3,2D3,7D;
SMILES Code
[2H]C([2H])(C([2H])(NCC(O)C1=CC(O)=C(O)C=C1)C([2H])([2H])[2H])[2H].Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 254.76 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Hsu E, Bajaj T. Beta 2 Agonists. 2021 May 28. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan–. PMID: 31194406. 2: Szymanski MW, Singh DP. Isoproterenol. 2021 May 1. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan–. PMID: 30252298. 3: Nakajima T, Tamura S, Kurabayashi M, Kaneko Y. Towards Mutation-Specific Precision Medicine in Atypical Clinical Phenotypes of Inherited Arrhythmia Syndromes. Int J Mol Sci. 2021 Apr 10;22(8):3930. doi: 10.3390/ijms22083930. PMID: 33920294; PMCID: PMC8069124. 4: Alhayek S, Preuss CV. Beta 1 Receptors. 2021 Feb 17. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan–. PMID: 30422499. 5: He H, Ma Y, Huang H, Huang C, Chen Z, Chen D, Gu Y, Wang X, Chen J. A comprehensive understanding about the pharmacological effect of diallyl disulfide other than its anti-carcinogenic activities. Eur J Pharmacol. 2021 Feb 15;893:173803. doi: 10.1016/j.ejphar.2020.173803. Epub 2020 Dec 24. PMID: 33359648. 6: Chowdhury A, Nabila J, Adelusi Temitope I, Wang S. Current etiological comprehension and therapeutic targets of acetaminophen-induced hepatotoxicity. Pharmacol Res. 2020 Nov;161:105102. doi: 10.1016/j.phrs.2020.105102. Epub 2020 Jul 30. PMID: 32738495. 7: Guevorkian AG. The effect of hypothalamic peptides, neurohormone C and proline-rich peptide-1on the Ca2+-handling system in heartin pathophysiological conditions. Heliyon. 2020 Jun 29;6(6):e04360. doi: 10.1016/j.heliyon.2020.e04360. PMID: 32637717; PMCID: PMC7330072. 8: García A, Bustillos-García GA, Rivera-Rodríguez L. Pediatrics patients head- up tilt test with pharmacological challenge, it is safe? Arch Cardiol Mex. 2020;90(2):178-188. English. doi: 10.24875/ACM.19000260. PMID: 32459207. 9: Hosoi K, Yao C, Hasegawa T, Yoshimura H, Akamatsu T. Dynamics of Salivary Gland AQP5 under Normal and Pathologic Conditions. Int J Mol Sci. 2020 Feb 11;21(4):1182. doi: 10.3390/ijms21041182. PMID: 32053992; PMCID: PMC7072788. 10: Aksu T, Guler TE, Bozyel S, Yalin K. Usage of a new mapping algorithm to detect possible critical substrate for continuity of atrial fibrillation: fractionation mapping in preliminary experience. J Interv Card Electrophysiol. 2020 Jun;58(1):29-34. doi: 10.1007/s10840-019-00693-x. Epub 2020 Jan 27. PMID: 31984467. 11: Teigeler T, Stahura H, Alimohammad R, Kalahasty G, Koneru JN, Ellenbogen M, Ellenbogen KA, Padala SK. Electrocardiographic changes in loperamide toxicity: Case report and review of literature. J Cardiovasc Electrophysiol. 2019 Nov;30(11):2618-2626. doi: 10.1111/jce.14129. Epub 2019 Aug 29. PMID: 31432581. 12: Okada M, Yamawaki H. A current perspective of canstatin, a fragment of type IV collagen alpha 2 chain. J Pharmacol Sci. 2019 Feb;139(2):59-64. doi: 10.1016/j.jphs.2018.12.001. Epub 2018 Dec 10. PMID: 30580971. 13: Kislitsina ON, Rich JD, Wilcox JE, Pham DT, Churyla A, Vorovich EB, Ghafourian K, Yancy CW. Shock - Classification and Pathophysiological Principles of Therapeutics. Curr Cardiol Rev. 2019;15(2):102-113. doi: 10.2174/1573403X15666181212125024. PMID: 30543176; PMCID: PMC6520577. 14: Hashem-Dabaghian F, Ziaee M, Ghaffari S, Nabati F, Kianbakht S. A systematic review on the cardiovascular pharmacology of Emblica officinalis Gaertn. J Cardiovasc Thorac Res. 2018;10(3):118-128. doi: 10.15171/jcvtr.2018.20. Epub 2018 Sep 25. PMID: 30386531; PMCID: PMC6203864. 15: Monasky MM, Pappone C, Piccoli M, Ghiroldi A, Micaglio E, Anastasia L. Calcium in Brugada Syndrome: Questions for Future Research. Front Physiol. 2018 Aug 10;9:1088. doi: 10.3389/fphys.2018.01088. PMID: 30147658; PMCID: PMC6095984. 16: Allawadhi P, Khurana A, Sayed N, Kumari P, Godugu C. Isoproterenol-induced cardiac ischemia and fibrosis: Plant-based approaches for intervention. Phytother Res. 2018 Oct;32(10):1908-1932. doi: 10.1002/ptr.6152. Epub 2018 Jul 15. PMID: 30009418. 17: Brodie OT, Michowitz Y, Belhassen B. Pharmacological Therapy in Brugada Syndrome. Arrhythm Electrophysiol Rev. 2018 Jun;7(2):135-142. doi: 10.15420/aer.2018.21.2. PMID: 29967687; PMCID: PMC6020192. 18: Tokas T, Skolarikos A, Herrmann TRW, Nagele U; Training and Research in Urological Surgery and Technology (T.R.U.S.T.)-Group. Pressure matters 2: intrarenal pressure ranges during upper-tract endourological procedures. World J Urol. 2019 Jan;37(1):133-142. doi: 10.1007/s00345-018-2379-3. Epub 2018 Jun 18. PMID: 29915944. 19: Ma D, Zhang J, Zhang Y, Zhang X, Han X, Song T, Zhang Y, Chu L. Inhibition of myocardial hypertrophy by magnesium isoglycyrrhizinate through the TLR4/NF-κB signaling pathway in mice. Int Immunopharmacol. 2018 Feb;55:237-244. doi: 10.1016/j.intimp.2017.12.019. Epub 2017 Dec 22. PMID: 29274625. 20: AlTurki A, Marshall HJ, Proietti R. Targeting nonpulmonary vein triggers during atrial fibrillation ablation: is the game worth the candle? Curr Opin Cardiol. 2018 Jan;33(1):50-57. doi: 10.1097/HCO.0000000000000469. PMID: 29135523.

View History

Malathion monoacid

Malathion monoacid