Z-FR-AMC TFA | CAS#unknown | Cathepsin L fluorogenic substrate

MedKoo Cat#: 464993 | Name: Z-FR-AMC TFA

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Z-FR-AMC is a fluorogenic substrate for cathepsin L. Upon enzymatic cleavage by cathepsin L, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify cathepsin L activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively.

Chemical Structure

Z-FR-AMC TFA

CAS#unknown

Theoretical Analysis

MedKoo Cat#: 464993

Name: Z-FR-AMC TFA

CAS#: unknown

Chemical Formula: C35H37F3N6O8

Exact Mass: 726.2625

Molecular Weight: 726.71

Elemental Analysis: C, 57.85; H, 5.13; F, 7.84; N, 11.56; O, 17.61

Price and Availability

Size	Price	Availability
10mg	USD 350.00	2 Weeks
25mg	USD 550.00	2 Weeks
50mg	USD 800.00	2 Weeks

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Related CAS #

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Synonym

Z-FR-AMC TFA; ZFRAMC TFA; Z FR AMC TFA; Z-FRAMC TFA; Z-FR AMC TFA; ZFR-AMC TFA; Z FR-AMC TFA; Z-FR-7-amino-4-Methylcoumarin; Z-Phe-Arg-AMC;

IUPAC/Chemical Name

benzyl ((S)-1-(((S)-5-guanidino-1-((4-methyl-2-oxo-2H-chromen-7-yl)amino)-1-oxopentan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate 2,2,2-trifluoroacetate

InChi Key

AVPSADNFAQBJBZ-WMXJXTQLSA-N

InChi Code

InChI=1S/C33H36N6O6.C2HF3O2/c1-21-17-29(40)45-28-19-24(14-15-25(21)28)37-30(41)26(13-8-16-36-32(34)35)38-31(42)27(18-22-9-4-2-5-10-22)39-33(43)44-20-23-11-6-3-7-12-23;3-2(4,5)1(6)7/h2-7,9-12,14-15,17,19,26-27H,8,13,16,18,20H2,1H3,(H,37,41)(H,38,42)(H,39,43)(H4,34,35,36);(H,6,7)/t26-,27-;/m0./s1

SMILES Code

CC(C1=CC=C(C=C1O2)NC([C@@H](NC([C@H](CC3=CC=CC=C3)NC(OCC4=CC=CC=C4)=O)=O)CCCNC(N)=N)=O)=CC2=O.OC(C(F)(F)F)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

	Solvent	mg/mL	mM
Solubility
	DMF	1.0	1.38
	DMSO	1.0	1.38
	Ethanol	1.0	1.38

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 726.71 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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