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MedKoo Cat#: 577110 | Name: Melphalan methyl ester

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Melphalan methyl ester is an alkylating nitrogen mustard that is used as an antineoplastic.

Chemical Structure

Melphalan methyl ester
Melphalan methyl ester
CAS#88457-23-2

Theoretical Analysis

MedKoo Cat#: 577110

Name: Melphalan methyl ester

CAS#: 88457-23-2

Chemical Formula: C14H20Cl2N2O2

Exact Mass: 318.0902

Molecular Weight: 319.23

Elemental Analysis: C, 52.68; H, 6.32; Cl, 22.21; N, 8.78; O, 10.02

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Melphalan methyl ester
IUPAC/Chemical Name
4-Bis(2-chloroethyl)amino-L-phenylalanine methyl ester
InChi Key
YHYUQHQOUXSXQE-ZDUSSCGKSA-N
InChi Code
InChI=1S/C14H20Cl2N2O2/c1-20-14(19)13(17)10-11-2-4-12(5-3-11)18(8-6-15)9-7-16/h2-5,13H,6-10,17H2,1H3/t13-/m0/s1
SMILES Code
COC(=O)[C@@H](N)Cc1ccc(cc1)N(CCCl)CCCl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 319.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Noesslinger T, Panny M, Simanek R, Moestl M, Boehm A, Menschel E, Koller E, Keil F. High dose Bendamustine-EAM followed by autologous stem cell rescue results in long term remission rates in lymphoma patients, without renal toxicty. Eur J Haematol. 2018 May 25. doi: 10.1111/ejh.13102. [Epub ahead of print] PubMed PMID: 29799642. 2: Jain T, Kunze KL, Temkit M, Partain DK, Patnaik MS, Slack JL, Khera N, Hogan WJ, Roy V, Noel P, Leis JF, Sproat LZ, Fauble V, Mesa RA, Palmer J. Comparison of reduced intensity conditioning regimens used in patients undergoing hematopoietic stem cell transplantation for myelofibrosis. Bone Marrow Transplant. 2018 May 24. doi: 10.1038/s41409-018-0226-1. [Epub ahead of print] PubMed PMID: 29795431. 3: Adam Z, Ozábalová E, Němec P, Bedáňová H, Kuman M, Krejčí J, Špinarová L, Žampachová V, Čermáková Z, Pour L, Krejčí M, Sanecká V, Štork M, Pika T, Straub J, Adamová D, Stavařová Y, Král Z, Mayer J. [Heart transplantation and follow-up treatment with AL-amyloidosis in 5 patients]. Vnitr Lek. 2018 Spring;64(4):441-449. Czech. PubMed PMID: 29791180. 4: Aggarwal M, Agrawal N, Yadav N, Verma P, Ahmed R, Mehta P, Kapoor J, Bhurani D. Autologous stem cell transplantation in first remission is associated with better progression-free survival in multiple myeloma. Ann Hematol. 2018 May 21. doi: 10.1007/s00277-018-3370-1. [Epub ahead of print] PubMed PMID: 29781040. 5: Katsarelias D, Rådbo E, Ben-Shabat I, Mattsson J, Olofsson Bagge R. The Effect of Temperature and Perfusion Time on Response, Toxicity, and Survival in Patients with In-transit Melanoma Metastases Treated with Isolated Limb Perfusion. Ann Surg Oncol. 2018 May 15. doi: 10.1245/s10434-018-6459-9. [Epub ahead of print] PubMed PMID: 29766389. 6: Al Malki MM, Nathwani N, Yang D, Armenian S, Dadwal S, Salman J, Mokhtari S, Cao T, Sandhu K, Rouse M, Mei M, Ali H, Parker P, Alvarnas J, Smith E, Donnell MO, Marcucci G, Snyder D, Nademanee A, Forman SJ, Stein A, Nakamura R. Melphalan-Based Reduced-Intensity Conditioning Is Associated with Favorable Disease Control and Acceptable Toxicities in Patients Older Than 70 with Hematologic Malignancies Undergoing Allogeneic Hematopoietic Stem Cell Transplantation. Biol Blood Marrow Transplant. 2018 May 9. pii: S1083-8791(18)30250-7. doi: 10.1016/j.bbmt.2018.04.029. [Epub ahead of print] PubMed PMID: 29753158. 7: Dhakal B, D'Souza A, Lakshman A, Hamadani M, Chhabra S, Thompson R, Shah N, Pasquini M, Hari P. Pharmacokinetics of High-Dose Propylene Glycol-Free Melphalan in Multiple Myeloma Patients Undergoing Autologous Hematopoietic Cell Transplantation. Biol Blood Marrow Transplant. 2018 May 8. pii: S1083-8791(18)30249-0. doi: 10.1016/j.bbmt.2018.04.028. [Epub ahead of print] PubMed PMID: 29751116. 8: Endo T, Hamada T, Otake S, Nakagawa M, Uchino Y, Takahashi H, Miura K, Iriyama N, Koike T, Kurihara K, Sato H, Hatta Y, Takei M. [Achievement of a stringent complete response with low-dose pomalidomide monotherapy in a multiple myeloma patient]. Rinsho Ketsueki. 2018;59(4):395-400. doi: 10.11406/rinketsu.59.395. Japanese. PubMed PMID: 29743398. 9: Jindahra P, Dejthevaporn C, Niparuck P, Waisayarat J, Cheecharoen P, Threetong T, Petpiroon P, Sujirakul T, Poonyathalang A, Vanikieti K. Atypical central retinal artery occlusion as the first presentation of POEMS syndrome: a case report. BMC Neurol. 2018 May 8;18(1):64. doi: 10.1186/s12883-018-1071-y. PubMed PMID: 29739345; PubMed Central PMCID: PMC5938810. 10: Fan FS, Yang CF. Complete response to orally administered melphalan in malignant pleural effusion from an occult female genital organ primary neoplasm with BRCA1/2 mutations: a case report. J Med Case Rep. 2018 May 6;12(1):122. doi: 10.1186/s13256-018-1674-3. PubMed PMID: 29729664; PubMed Central PMCID: PMC5936624. 11: Hishiki T, Matsumoto K, Ohira M, Kamijo T, Shichino H, Kuroda T, Yoneda A, Soejima T, Nakazawa A, Takimoto T, Yokota I, Teramukai S, Takahashi H, Fukushima T, Kaneko T, Hara J, Kaneko M, Ikeda H, Tajiri T, Nakagawara A; Japan Childhood Cancer Group Neuroblastoma Committee (JNBSG). Results of a phase II trial for high-risk neuroblastoma treatment protocol JN-H-07: a report from the Japan Childhood Cancer Group Neuroblastoma Committee (JNBSG). Int J Clin Oncol. 2018 Apr 26. doi: 10.1007/s10147-018-1281-8. [Epub ahead of print] PubMed PMID: 29700636. 12: Hathi D, DeLassus E, Achilefu S, McConathy J, Shokeen M. Imaging melphalan therapy response in preclinical extramedullary myeloma with (18)F-FDOPA and (18)F-FDG PET. J Nucl Med. 2018 Apr 26. pii: jnumed.118.208744. doi: 10.2967/jnumed.118.208744. [Epub ahead of print] PubMed PMID: 29700126. 13: Singh N, Ecker GF. Insights into the Structure, Function, and Ligand Discovery of the Large Neutral Amino Acid Transporter 1, LAT1. Int J Mol Sci. 2018 Apr 24;19(5). pii: E1278. doi: 10.3390/ijms19051278. Review. PubMed PMID: 29695141. 14: Funes S, Sampor C, Villasante F, Fandiño A, Manzitti J, Sgroi M, Neira P, Peralta L, Lagomarsino E, Schaiquevich P, Ceciliano A, Chantada GL. Feasibility and results of an intraarterial chemotherapy program for the conservative treatment of retinoblastoma in Argentina. Pediatr Blood Cancer. 2018 Apr 25:e27086. doi: 10.1002/pbc.27086. [Epub ahead of print] PubMed PMID: 29693791. 15: Kubota H, Umeda K, Kagehiro K, Tanaka K, Daifu T, Hamabata T, Nodomi S, Kato I, Hiramatsu H, Arakawa Y, Mizowaki T, Adachi S. High-dose chemotherapy with autologous stem cell transplantation spares re-irradiation for recurrent intracranial germinoma. Pediatr Blood Cancer. 2018 Apr 25:e27104. doi: 10.1002/pbc.27104. [Epub ahead of print] PubMed PMID: 29693779. 16: Borrelli C, Ricci B, Vulpis E, Fionda C, Ricciardi MR, Petrucci MT, Masuelli L, Peri A, Cippitelli M, Zingoni A, Santoni A, Soriani A. Drug-induced senescent Multiple Myeloma cells elicit NK cell proliferation by direct or exosome-mediated IL-15 trans-presentation. Cancer Immunol Res. 2018 Apr 24. pii: canimm.0604.2017. doi: 10.1158/2326-6066.CIR-17-0604. [Epub ahead of print] PubMed PMID: 29691234. 17: Scordo M, Morjaria SM, Littmann ER, Bhatia A, Chung HH, Maloy M, DeAngelis LM, Giralt SA, Taur Y, Sauter CS. Distinctive Infectious Complications in Patients with Central Nervous System Lymphoma Undergoing Thiotepa, Busulfan, and Cyclophosphamide-Conditioned Autologous Stem Cell Transplantation. Biol Blood Marrow Transplant. 2018 Apr 18. pii: S1083-8791(18)30194-0. doi: 10.1016/j.bbmt.2018.04.013. [Epub ahead of print] PubMed PMID: 29679773. 18: Badar T, Hari P, Chhabra S, Dhakal B, Drobyski WR, Fenske TS, Hamadani M, Pasquini M, Saber W, Shah NN, Shaw BE, D'Souza A. Use of propylene glycol-free melphalan conditioning in light-chain amyloidosis patients undergoing autologous hematopoietic cell transplantation is well tolerated and effective. Bone Marrow Transplant. 2018 Apr 20. doi: 10.1038/s41409-018-0178-5. [Epub ahead of print] PubMed PMID: 29679076. 19: Fridthjof KS, Kampmann P, Dünweber A, Gørløv JS, Nexø C, Friis LS, Nørskov KH, Welinder PC, Moser C, Kjeldsen L, Møller T. Systematic patient involvement for homebased outpatient administration of complex chemotherapy in acute leukemia and lymphoma. Br J Haematol. 2018 Jun;181(5):637-641. doi: 10.1111/bjh.15249. Epub 2018 Apr 20. PubMed PMID: 29676445. 20: Jodele S, Dandoy CE, Myers K, Wallace G, Lane A, Teusink-Cross A, Weiss B, Davies SM. High-dose Carboplatin/Etoposide/Melphalan increases risk of thrombotic microangiopathy and organ injury after autologous stem cell transplantation in patients with neuroblastoma. Bone Marrow Transplant. 2018 Apr 19. doi: 10.1038/s41409-018-0159-8. [Epub ahead of print] PubMed PMID: 29674658.