Related CAS #
82-88-2 (free base); 569-59-5 (tartrate); 5503-08-2 (HCl)
Synonym
Phenindamine hydrochloride; Phenindamine HCl; NU1504 hydrochloride; NU-1504 hydrochloride; NU 1504 hydrochloride
IUPAC/Chemical Name
1H-Indeno(2,1-c)pyridine, 2,3,4,9-tetrahydro-2-methyl-9-phenyl-, hydrochloride
InChi Key
QOBFRYKYYDPOEC-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H19N.ClH/c1-20-12-11-16-15-9-5-6-10-17(15)19(18(16)13-20)14-7-3-2-4-8-14;/h2-10,19H,11-13H2,1H3;1H
SMILES Code
CN1CCC2=C(C(C3=CC=CC=C3)C4=C2C=CC=C4)C1.[H]Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
0.00
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. Phenindamine. 2021 Sep 20. PMID: 30000124.
2: Martínez-Gómez MA, Villanueva-Camañas RM, Sagrado S, Medina-Hernández MJ. Evaluation of enantioselective binding of basic drugs to plasma by ACE. Electrophoresis. 2007 Aug;28(17):3056-63. doi: 10.1002/elps.200700222. PMID: 17661317.
3: Martínez-Gómez MA, Carril-Avilés MM, Sagrado S, Villanueva-Camañas RM, Medina-Hernández MJ. Characterization of antihistamine-human serum protein interactions by capillary electrophoresis. J Chromatogr A. 2007 Apr 20;1147(2):261-9. doi: 10.1016/j.chroma.2007.02.054. Epub 2007 Feb 22. PMID: 17339039.
4: ter Laak AM, Venhorst J, Donné-Op den Kelder GM, Timmerman H. The histamine H1-receptor antagonist binding site. A stereoselective pharmacophoric model based upon (semi-)rigid H1-antagonists and including a known interaction site on the receptor. J Med Chem. 1995 Aug 18;38(17):3351-60. doi: 10.1021/jm00017a019. PMID: 7650688.
5: Witek TJ Jr, Canestrari DA, Miller RD, Yang JY, Riker DK. The effects of phenindamine tartrate on sleepiness and psychomotor performance. J Allergy Clin Immunol. 1992 Dec;90(6 Pt 1):953-61. doi: 10.1016/0091-6749(92)90468-h. PMID: 1360991.
6: van Drooge MJ, Donné-op den Kelder GM, Timmerman H. The histamine H1-receptor antagonist binding site. Part I: Active conformation of cyproheptadine. J Comput Aided Mol Des. 1991 Aug;5(4):357-70. doi: 10.1007/BF00126668. PMID: 1686618.
7: Helman MD, Re TA, Lukacsko AB. Antiperspirant activity of H1-histamine blockers as determined by a modified rat foot pad assay. Pharm Res. 1989 Oct;6(10):883-6. doi: 10.1023/a:1015916707168. PMID: 2575256.
8: Maurer H, Pfleger K. Identification and differentiation of alkylamine antihistamines and their metabolites in urine by computerized gas chromatography-mass spectrometry. J Chromatogr. 1988 Aug 19;430(1):31-41. doi: 10.1016/s0378-4347(00)83131-x. PMID: 2905706.
9: Bergman J, Spealman RD. Behavioral effects of histamine H1 antagonists: comparison with other drugs and modification by haloperidol. J Pharmacol Exp Ther. 1988 May;245(2):471-8. PMID: 2896793.
10: Branch SK, Casy AF, Hussain R, Upton C. The structure of phenindamine base and salts in the solute state. J Pharm Pharmacol. 1988 Jan;40(1):83-4. doi: 10.1111/j.2042-7158.1988.tb05164.x. PMID: 2896790.
11: Sigidinenko LV. O nekotorykh printsipakh terapevticheskoĭ taktiki u bol'nykh épilepsieĭ v period beremennosti [Various principles of therapeutic tactics in epilepsy patients during pregnancy]. Zh Nevropatol Psikhiatr Im S S Korsakova. 1984;84(6):897-9. Russian. PMID: 6147056.
12: Knoll J, Kerecsen L, Somogyi GT, Kovács A. Opiate agonists inhibit noradrenaline release via opiate B-receptors and N-cyclopropylmethylnorazidomorphine (CAM) blocks electrically evoked contractions via histamine in the mouse vas deferens. Arch Int Pharmacodyn Ther. 1981 May;251(1):52-65. PMID: 6266359.
13: Kovács P, Darvas Z, Csaba G. Investigation of histamine-antihistamine differentiation ability of Tetrahymena receptors, by means of lectins and antihistamine antibodies. Acta Biol Acad Sci Hung. 1981;32(2):111-7. PMID: 6800167.
14: Darvas Z, Csaba G. Effect of histamine and histamine antagonists on the glycogen content of Tetrahymena. Acta Physiol Acad Sci Hung. 1981;58(1):9-14. PMID: 6123219.
15: Tscherne RJ, Umagat H. Determination of isophenindamine in phenindamine tartrate using an argentated high-performance liquid chromatographic mobile phase. J Pharm Sci. 1980 Mar;69(3):342-4. doi: 10.1002/jps.2600690324. PMID: 7381716.
16: Csaba G, László V, Darvas Z. Effects of H1 and H2 receptor antagonists on Tetrahymena. Acta Biol Med Ger. 1978;37(1):161-3. PMID: 100995.
17: Pórszász J, Gibiszer KP, Pórszász J Jr. Pharmacological investigation on the neurohumoral transmission of the vasomotor regulation. Acta Physiol Acad Sci Hung. 1977;49(2):139-65. PMID: 38630.
18: Ts'o TO, Hance AJ, Killam KF. Performance enhancement effects of d-amphetamine, methylphenidate, pipradrol and phenindamine in rats. Psychopharmacologia. 1976;46(1):65-72. doi: 10.1007/BF00421551. PMID: 3816.
19: Abdallah A, White HD. Comparative study of the anorectic activity of phenindamine d-amphetamine and fenfluramine in different species. Arch Int Pharmacodyn Ther. 1970 Dec;188(2):271-83. PMID: 5523473.
20: PANJWANI MH, JOSEPH AD, RAJAPURKAR MV, SAGHDEV KS. ADRENERGIC BLOCKADE PRODUCED BY THEPHORIN AND TOLAZOLINE HYDROCHLORIDE WITH SPECIAL REFERENCE TO THE BLOCKADE OF INTESTINAL RECEPTORS. Indian J Physiol Pharmacol. 1963 Oct;7:197-209. PMID: 14173943.
