MedKoo Cat#: 464984 | Name: LUM88786
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

LUM88786 is an active phosphodiester metabolite of phosphatidylethanolamine. It promotes aggregation of amyloid-β (1-40) (Aβ40) in vitro, and levels of LUM88786 are elevated in postmortem brains isolated from patients with Alzheimer's disease. This product has no formal name. For the convenience of scientific communication, we named it by combining its InChi Key (3 letters from the first letter of each section) with the last 5 digit of its CAS#) according to MedKoo Chemical Nomenclature (https://www.medkoo.com/page/naming).

Chemical Structure

LUM88786
LUM88786
CAS#883288-78-6

Theoretical Analysis

MedKoo Cat#: 464984

Name: LUM88786

CAS#: 883288-78-6

Chemical Formula: C5H13NNaO6P

Exact Mass: 0.0000

Molecular Weight: 237.12

Elemental Analysis: C, 25.33; H, 5.53; N, 5.91; Na, 9.70; O, 40.48; P, 13.06

Price and Availability

Size Price Availability Quantity
1mg USD 450.00 2 Weeks
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Related CAS #
No Data
Synonym
LUM88786; LUM 88786; LUM-88786; Glycerol 3 phosphorylethanolamine; Glycerylphosphorylethanolamine; Glycerophosphorylethanolamine sodium salt;
IUPAC/Chemical Name
sodium 2-aminoethyl (2,3-dihydroxypropyl) phosphate
InChi Key
LMVDUYIAODUIQA-UHFFFAOYSA-M
InChi Code
InChI=1S/C5H14NO6P.Na/c6-1-2-11-13(9,10)12-4-5(8)3-7;/h5,7-8H,1-4,6H2,(H,9,10);/q;+1/p-1
SMILES Code
O=P(OCC(O)CO)([O-])OCCN.[Na+]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 237.12 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Su H, Rustam YH, Masters CL, Makalic E, McLean CA, Hill AF, Barnham KJ, Reid GE, Vella LJ. Characterization of brain-derived extracellular vesicle lipids in Alzheimer's disease. J Extracell Vesicles. 2021 May;10(7):e12089. doi: 10.1002/jev2.12089. Epub 2021 May 11. PMID: 34012516; PMCID: PMC8111496. 2: Fujiogi M, Camargo CA Jr, Raita Y, Zhu Z, Celedón JC, Mansbach JM, Spergel JM, Hasegawa K. Integrated associations of nasopharyngeal and serum metabolome with bronchiolitis severity and asthma: A multicenter prospective cohort study. Pediatr Allergy Immunol. 2021 Jul;32(5):905-916. doi: 10.1111/pai.13466. Epub 2021 Mar 4. PMID: 33559342; PMCID: PMC8269431. 3: Wood PL, Muir W, Christmann U, Gibbons P, Hancock CL, Poole CM, Emery AL, Poovey JR, Hagg C, Scarborough JH, Christopher JS, Dixon AT, Craney DJ. Lipidomics of the chicken egg yolk: high-resolution mass spectrometric characterization of nutritional lipid families. Poult Sci. 2021 Feb;100(2):887-899. doi: 10.1016/j.psj.2020.11.020. Epub 2020 Nov 17. PMID: 33518142; PMCID: PMC7858096. 4: Li J, Zheng H, Xu EY, Moehwald M, Chen L, Zhang X, Mao S. Inhalable PLGA microspheres: Tunable lung retention and systemic exposure via polyethylene glycol modification. Acta Biomater. 2021 Mar 15;123:325-334. doi: 10.1016/j.actbio.2020.12.061. Epub 2021 Jan 14. PMID: 33454386. 5: Xie HK, Zhao GH, Wu ZX, Li DY, Zhao MT, Li A, Liu HL, Zhou DY, Zhu BW. Differences in oxidative susceptibilities between glycerophosphocholine and glycerophosphoethanolamine in dried scallop (Argopecten irradians) adductor muscle during storage: an oxidation kinetic assessment. J Sci Food Agric. 2021 Mar 15;101(4):1554-1561. doi: 10.1002/jsfa.10774. Epub 2020 Sep 17. PMID: 32869299. 6: Hewelt-Belka W, Garwolińska D, Młynarczyk M, Kot-Wasik A. Comparative Lipidomic Study of Human Milk from Different Lactation Stages and Milk Formulas. Nutrients. 2020 Jul 21;12(7):2165. doi: 10.3390/nu12072165. PMID: 32708300; PMCID: PMC7401268. 7: Horibata Y, Ando H, Sugimoto H. Locations and contributions of the phosphotransferases EPT1 and CEPT1 to the biosynthesis of ethanolamine phospholipids. J Lipid Res. 2020 Aug;61(8):1221-1231. doi: 10.1194/jlr.RA120000898. Epub 2020 Jun 23. PMID: 32576654; PMCID: PMC7397746. 8: Li CY, Niu M, Liu YL, Tang JF, Chen W, Qian G, Zhang MY, Shi YF, Lin JZ, Li XJ, Li RS, Xiao XH, Li GH, Wang JB. Screening for Susceptibility-Related Factors and Biomarkers of Xianling Gubao Capsule-Induced Liver Injury. Front Pharmacol. 2020 May 29;11:810. doi: 10.3389/fphar.2020.00810. PMID: 32547402; PMCID: PMC7274038. 9: B Gowda SG, Fuda H, Yamamoto Y, Chiba H, Hui SP. A Simple and Efficient Method for Synthesis of sn-Glycero-Phosphoethanolamine. Lipids. 2020 Jul;55(4):395-401. doi: 10.1002/lipd.12243. Epub 2020 May 13. PMID: 32406068. 10: Liu T, Tan Z, Yu J, Peng F, Guo J, Meng W, Chen Y, Rao T, Liu Z, Peng J. A conjunctive lipidomic approach reveals plasma ethanolamine plasmalogens and fatty acids as early diagnostic biomarkers for colorectal cancer patients. Expert Rev Proteomics. 2020 Mar;17(3):233-242. doi: 10.1080/14789450.2020.1757443. Epub 2020 May 4. PMID: 32306783. 11: Daniele S, Mangano G, Durando L, Ragni L, Martini C. The Nootropic Drug Α-Glyceryl-Phosphoryl-Ethanolamine Exerts Neuroprotective Effects in Human Hippocampal Cells. Int J Mol Sci. 2020 Jan 31;21(3):941. doi: 10.3390/ijms21030941. PMID: 32023864; PMCID: PMC7038199. 12: Kim HJ, Sparrow JR. Bisretinoids: More than Meets the Eye. Adv Exp Med Biol. 2019;1185:341-346. doi: 10.1007/978-3-030-27378-1_56. PMID: 31884635. 13: Severiano DLR, Oliveira-Lima OC, Vasconcelos GA, Lemes Marques B, Almeida de Carvalho G, Freitas EMM, Xavier CH, Gomez MV, Pinheiro ACO, Gomez RS, Vaz BG, Pinto MCX. Cerebral Lipid Dynamics in Chronic Cerebral Hypoperfusion Model by DESI-MS Imaging. Neuroscience. 2020 Feb 1;426:1-12. doi: 10.1016/j.neuroscience.2019.11.014. Epub 2019 Nov 27. PMID: 31785353. 14: Shen Y, Xie HK, Liu ZY, Lu T, Yu ZL, Zhang LH, Zhou DY, Wang T. Characterization of glycerophospholipid molecular species in muscles from three species of cephalopods by direct infusion-tandem mass spectrometry. Chem Phys Lipids. 2020 Jan;226:104848. doi: 10.1016/j.chemphyslip.2019.104848. Epub 2019 Nov 6. PMID: 31705861. 15: Al-Sulaiti H, Diboun I, Agha MV, Mohamed FFS, Atkin S, Dömling AS, Elrayess MA, Mazloum NA. Metabolic signature of obesity-associated insulin resistance and type 2 diabetes. J Transl Med. 2019 Oct 22;17(1):348. doi: 10.1186/s12967-019-2096-8. PMID: 31640727; PMCID: PMC6805293. 16: Corrêa ACNTF, Pereira PR, Paschoalin VMF. Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins. J Vis Exp. 2019 Aug 31;(150). doi: 10.3791/59900. PMID: 31524878. 17: Fernández-López M, Gil-de-la-Fuente A, Godzien J, Rupérez FJ, Barbas C, Otero A. LAS: A Lipid Annotation Service Capable of Explaining the Annotations It Generates. Comput Struct Biotechnol J. 2019 Jul 30;17:1113-1122. doi: 10.1016/j.csbj.2019.07.016. PMID: 31462967; PMCID: PMC6709375. 18: Krikken E, van der Kemp WJM, van Diest PJ, van Dalen T, van Laarhoven HWM, Luijten PR, Klomp DWJ, Wijnen JP. Early detection of changes in phospholipid metabolism during neoadjuvant chemotherapy in breast cancer patients using phosphorus magnetic resonance spectroscopy at 7T. NMR Biomed. 2019 Jun;32(6):e4086. doi: 10.1002/nbm.4086. Epub 2019 Mar 29. PMID: 30924571; PMCID: PMC6593799. 19: Tran QT, Le TTT, Pham MQ, Do TL, Vu MH, Nguyen DC, Bach LG, Bui LM, Pham QL. Fatty Acid, Lipid Classes and Phospholipid Molecular Species Composition of the Marine Clam Meretrix lyrata (Sowerby 1851) from Cua Lo Beach, Nghe An Province, Vietnam. Molecules. 2019 Mar 4;24(5):895. doi: 10.3390/molecules24050895. PMID: 30836630; PMCID: PMC6429517. 20: Martínez-Ávila JC, García Bartolomé A, García I, Dapía I, Tong HY, Díaz L, Guerra P, Frías J, Carcás Sansuan AJ, Borobia AM. Pharmacometabolomics applied to zonisamide pharmacokinetic parameter prediction. Metabolomics. 2018 May 9;14(5):70. doi: 10.1007/s11306-018-1365-5. Erratum in: Metabolomics. 2018 Jun 14;14(6):87. PMID: 30830352.