Synonym
Npc 12626; Npc12626; Npc-12626
IUPAC/Chemical Name
Cyclohexanepropanoic acid, alpha-amino-2-(2-phosphonoethyl)-
InChi Key
DHJQWBSZKBDBFP-UHFFFAOYSA-N
InChi Code
InChI=1S/C11H22NO5P/c12-10(11(13)14)7-9-4-2-1-3-8(9)5-6-18(15,16)17/h8-10H,1-7,12H2,(H,13,14)(H2,15,16,17)
SMILES Code
O=C(O)C(N)CC1C(CCP(O)(O)=O)CCCC1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
279.27
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Bobelis DJ, Balster RL. Pharmacological specificity of the discriminative stimulus properties of 2-amino-4,5-(1,2-cyclohexyl)-7-phosphono-heptanoic acid (NPC 12626), a competitive N-methyl-D-aspartate receptor antagonist. J Pharmacol Exp Ther. 1993 Feb;264(2):845-53. PMID: 8437128.
2: Willetts J, Bobelis DJ, Balster RL. Drug discrimination based on the competitive N-methyl-D-aspartate antagonist, NPC 12626. Psychopharmacology (Berl). 1989;99(4):458-62. doi: 10.1007/BF00589892. PMID: 2687923.
3: Walker DL, Gold PE. Effects of the novel NMDA antagonist, NPC 12626, on long- term potentiation, learning and memory. Brain Res. 1991 May 24;549(2):213-21. doi: 10.1016/0006-8993(91)90460-d. PMID: 1832074.
4: Kavaliers M, Choleris E, Saucier DM. The NMDA receptor antagonist, NPC 12626, reduces the pronociceptive effects of orphanin FQ and kappa opiate antinociception in the land snail, Cepaea nemoralis. Peptides. 1997;18(7):943-7. doi: 10.1016/s0196-9781(97)00037-5. PMID: 9357050.
5: Ferkany JW, Kyle DJ, Willets J, Rzeszotarski WJ, Guzewska ME, Ellenberger SR, Jones SM, Sacaan AI, Snell LD, Borosky S, et al. Pharmacological profile of NPC 12626, a novel, competitive N-methyl-D-aspartate receptor antagonist. J Pharmacol Exp Ther. 1989 Jul;250(1):100-9. PMID: 2545856.
6: Ferkany JW, Kyle DJ, Rzeszotarski WJ. NPC 12626, a novel, competitive NMDA antagonist: pharmacological and toxicological profile. Prog Clin Biol Res. 1990;361:525-32. PMID: 2290850.
7: Saucier DM, Kavaliers M. Antagonistic effects of the selective, competitive N-methyl-D-aspartate (NMDA) receptor antagonist, NPC 12626, on kappa opiate- induced analgesia in male deer mice. Brain Res. 1994 Feb 21;637(1-2):292-6. doi: 10.1016/0006-8993(94)91247-5. PMID: 8180809.
8: Gold LH, Balster RL. Effects of NMDA receptor antagonists in squirrel monkeys trained to discriminate the competitive NMDA receptor antagonist NPC 12626 from saline. Eur J Pharmacol. 1993 Jan 19;230(3):285-92. doi: 10.1016/0014-2999(93)90563-w. PMID: 8095022.
9: Willetts J, Clissold DB, Hartman TL, Brandsgaard RR, Hamilton GS, Ferkany JW. Behavioral pharmacology of NPC 17742, a competitive N-methyl-D-aspartate (NMDA) antagonist. J Pharmacol Exp Ther. 1993 Jun;265(3):1055-62. PMID: 8099615.
10: Vogel MW, Prittie J. Purkinje cell dendritic arbors in chick embryos following chronic treatment with an N-methyl-D-aspartate receptor antagonist. J Neurobiol. 1995 Apr;26(4):537-52. doi: 10.1002/neu.480260407. PMID: 7602317.
