Noxiptilin HCl | CAS# 4985-15-3 (HCl) | proposed tricyclic antidepressent

MedKoo Cat#: 414506 | Name: Noxiptilin HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Noxiptilin HCl is a proposed tricyclic antidepressent.

Chemical Structure

Noxiptilin HCl

CAS#4985-15-3 (HCl)

Theoretical Analysis

MedKoo Cat#: 414506

Name: Noxiptilin HCl

CAS#: 4985-15-3 (HCl)

Chemical Formula: C19H23ClN2O

Exact Mass:

Molecular Weight: 330.86

Elemental Analysis: C, 68.98; H, 7.01; Cl, 10.71; N, 8.47; O, 4.84

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

3362-45-6 (free base); 4985-15-3 (HCl)

Synonym

Noxiptilin hydrochloride; Noxiptilin HCl; BAY1521; BAY-1521; BAY 1521

IUPAC/Chemical Name

10,11-Dihydro-5H-dibenzo(a,d)cyclohepten-5-one O-(2-(dimethylamino)ethyl)oxime monohydrochloride

InChi Key

JIKBYFBMUAUPJS-UHFFFAOYSA-N

InChi Code

InChI=1S/C19H22N2O.ClH/c1-21(2)13-14-22-20-19-17-9-5-3-7-15(17)11-12-16-8-4-6-10-18(16)19;/h3-10H,11-14H2,1-2H3;1H

SMILES Code

CN(CCO/N=C1C2=CC=CC=C2CCC3=CC=CC=C\13)C.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 330.86 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Bente D, Feder J, Belmchen H, Hippius H, Rosenberg L. Doppelblindprüfung von drei Antidepressiva. 2. Klinischer Vergleich von Noxiptilin, Nor-Noxiptilin und Amitriptylin mit dem AMP-System [Double-blind study on 3 antidepressive agents. 2. Clinical comparison of noxiptiline, nor-noxiptiline, and amitryptiline using the AMP system]. Arzneimittelforschung. 1973 Feb;23(2):247-55. German. PMID: 4573740. 2: Li M, Brito JP, Vaccarella S. Long-Term Declines of Thyroid Cancer Mortality: An International Age-Period-Cohort Analysis. Thyroid. 2020 Jun;30(6):838-846. doi: 10.1089/thy.2019.0684. Epub 2020 Mar 2. PMID: 31964280. 3: Barth N, Manns M, Muscholl E. Arrhythmias and inhibition of noradrenaline uptake caused by tricyclic antidepressants and chlorpromazine on the isolated perfused rabbit heart. Naunyn Schmiedebergs Arch Pharmacol. 1975;288(2-3):215-31. doi: 10.1007/BF00500528. PMID: 1161046. 4: Andrée G, Schmitt W, Meiser H. Psychopharmaka und Glaukom [Psychotropic drugs and glaucoma (author's transl)]. Klin Monbl Augenheilkd. 1976 May;168(05):637-43. German. PMID: 989144. 5: Lüllmann-Rauch R, Scheid D. Intraalveolar foam cells associated with lipidosis-like alterations in lung and liver of rats treated with tricyclic psychotropic drugs. Virchows Arch B Cell Pathol. 1975 Nov 21;19(3):255-68. doi: 10.1007/BF02889372. PMID: 174284. 6: Soria JA, Huisa BN, Edland SD, Litvan I, Peavy GM, Salmon DP, Hansen LA, Galasko DR, Brewer JB, González HM, Rissman RA. Clinical-Neuropathological Correlations of Alzheimer's Disease and Related Dementias in Latino Volunteers. J Alzheimers Dis. 2018;66(4):1539-1548. doi: 10.3233/JAD-180789. PMID: 30412501. 7: Cocchi A, Andreola ML. Morphologische Aspekte der Verabreichung von Noxiptilin (BAY 1521) im Tierexperiment [Morphological aspects of administration of noxiptiline (BAY 1521) in animal experiments]. Arzneimittelforschung. 1970 Jul;20(7):958-63. German. PMID: 5536070. 8: Ose E. Et kontrollert klinisk forsk med det nye antidepressivum noxiptilin sammenlignet med amitriptylin. Forelpig meddalse [A controlled clinical trial with the new antidepressive noxiptiline compared with amitriptyline. Preliminary study]. Nord Psykiatr Tidsskr. 1971;25(4):382-90. Norwegian. doi: 10.3109/08039487109094687. PMID: 4949345. 9: Juul S, Siddiqui F, Barbateskovic M, Jørgensen CK, Hengartner MP, Kirsch I, Gluud C, Jakobsen JC. Beneficial and harmful effects of antidepressants versus placebo, 'active placebo', or no intervention for adults with major depressive disorder: a protocol for a systematic review of published and unpublished data with meta-analyses and trial sequential analyses. Syst Rev. 2021 May 25;10(1):154. doi: 10.1186/s13643-021-01705-6. PMID: 34034811; PMCID: PMC8152051. 10: Albert K. Polarografische Gehaltsbestimmung von Noxiptilinhydrochlorid in Tabletten [Polarographic determination of noxiptilin hydrochloride in tablets]. Pharmazie. 1984 Aug;39(8):548-50. German. PMID: 6548813.