Related CAS #
3362-45-6 (free base); 4985-15-3 (HCl)
Synonym
Noxiptiline Free Base; BAY1521; BAY-1521 BAY 1521
IUPAC/Chemical Name
10,11-Dihydro-5H-dibenzo(a,d)cyclohepten-5-one O-(2-(dimethylamino)ethyl)oxime
InChi Key
GPTURHKXTUDRPC-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H22N2O/c1-21(2)13-14-22-20-19-17-9-5-3-7-15(17)11-12-16-8-4-6-10-18(16)19/h3-10H,11-14H2,1-2H3
SMILES Code
CN(CCO/N=C1C2=CC=CC=C2CCC3=CC=CC=C\13)C
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
294.39
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Bente D, Feder J, Belmchen H, Hippius H, Rosenberg L. Doppelblindprüfung von drei Antidepressiva. 2. Klinischer Vergleich von Noxiptilin, Nor-Noxiptilin und Amitriptylin mit dem AMP-System [Double-blind study on 3 antidepressive agents. 2. Clinical comparison of noxiptiline, nor-noxiptiline, and amitryptiline using the AMP system]. Arzneimittelforschung. 1973 Feb;23(2):247-55. German. PMID: 4573740.
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5: Lüllmann-Rauch R, Scheid D. Intraalveolar foam cells associated with lipidosis-like alterations in lung and liver of rats treated with tricyclic psychotropic drugs. Virchows Arch B Cell Pathol. 1975 Nov 21;19(3):255-68. doi: 10.1007/BF02889372. PMID: 174284.
6: Soria JA, Huisa BN, Edland SD, Litvan I, Peavy GM, Salmon DP, Hansen LA, Galasko DR, Brewer JB, González HM, Rissman RA. Clinical-Neuropathological Correlations of Alzheimer's Disease and Related Dementias in Latino Volunteers. J Alzheimers Dis. 2018;66(4):1539-1548. doi: 10.3233/JAD-180789. PMID: 30412501.
7: Cocchi A, Andreola ML. Morphologische Aspekte der Verabreichung von Noxiptilin (BAY 1521) im Tierexperiment [Morphological aspects of administration of noxiptiline (BAY 1521) in animal experiments]. Arzneimittelforschung. 1970 Jul;20(7):958-63. German. PMID: 5536070.
8: Ose E. Et kontrollert klinisk forsk med det nye antidepressivum noxiptilin sammenlignet med amitriptylin. Forelpig meddalse [A controlled clinical trial with the new antidepressive noxiptiline compared with amitriptyline. Preliminary study]. Nord Psykiatr Tidsskr. 1971;25(4):382-90. Norwegian. doi: 10.3109/08039487109094687. PMID: 4949345.
9: Juul S, Siddiqui F, Barbateskovic M, Jørgensen CK, Hengartner MP, Kirsch I, Gluud C, Jakobsen JC. Beneficial and harmful effects of antidepressants versus placebo, 'active placebo', or no intervention for adults with major depressive disorder: a protocol for a systematic review of published and unpublished data with meta-analyses and trial sequential analyses. Syst Rev. 2021 May 25;10(1):154. doi: 10.1186/s13643-021-01705-6. PMID: 34034811; PMCID: PMC8152051.
10: Albert K. Polarografische Gehaltsbestimmung von Noxiptilinhydrochlorid in Tabletten [Polarographic determination of noxiptilin hydrochloride in tablets]. Pharmazie. 1984 Aug;39(8):548-50. German. PMID: 6548813.
