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MedKoo Cat#: 414502 | Name: Levopropoxyphene napsylate anhydrous

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Levopropoxyphene napsylate anhydrous is a propionate derivative that is used to suppress coughing.

Chemical Structure

Levopropoxyphene napsylate anhydrous
Levopropoxyphene napsylate anhydrous
CAS#5714-90-9 (anhydrous)

Theoretical Analysis

MedKoo Cat#: 414502

Name: Levopropoxyphene napsylate anhydrous

CAS#: 5714-90-9 (anhydrous)

Chemical Formula: C32H37NO5S

Exact Mass: 547.2392

Molecular Weight: 547.71

Elemental Analysis: C, 70.17; H, 6.81; N, 2.56; O, 14.61; S, 5.85

Price and Availability

This product was removed for the commercial reasons.
Related CAS #
5714-90-9 (anhydrous); 55557-30-7 (free base)
Synonym
Levopropoxyphene napsylate anhydrous; Letusin; Contratuss; Regretos; Novrad
IUPAC/Chemical Name
2-Butanol, 4-(dimethylamino)-3-methyl-1,2-diphenyl-, propionate (ester), 2-naphthalenesulfonate (salt), (-)-
InChi Key
VZPXFHVJUUSVLH-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H29NO2.C10H8O3S/c1-5-21(24)25-22(18(2)17-23(3)4,20-14-10-7-11-15-20)16-19-12-8-6-9-13-19;11-14(12,13)10-6-5-8-3-1-2-4-9(8)7-10/h6-15,18H,5,16-17H2,1-4H3;1-7H,(H,11,12,13)
SMILES Code
CC(CN(C)C)C(C1=CC=CC=C1)(OC(CC)=O)CC2=CC=CC=C2.O=S(C3=CC=C4C=CC=CC4=C3)(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 547.71 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: McMahon RE, Sullivan HR. Reduction of levopropoxyphene N-oxide to propoxyphene by dogs in vivo and rat liver microsomal fraction in vitro. Xenobiotica. 1977 Jun;7(6):377-82. doi: 10.3109/00498257709035796. PMID: 610054. 2: Wainer IW. Three-dimensional view of pharmacology. Am J Hosp Pharm. 1992 Sep;49(9 Suppl 1):S4-8. Erratum in: Am J Hosp Pharm 1992 Dec;49(12):2929. PMID: 1530004. 3: SCHVARTSMAN S. INTOXICA C AO POR INGEST AO DE DOSE EXCESSIVA DE LEVOPROPOXIFENO (LETUSIN) [POISONING BY INGESTION OF AN EXCESSIVE DOSE OF LEVOPROPOXYPHENE (LETUSIN)]. Pediatr Prat. 1964;35:51-2. Portuguese. PMID: 14254473. 4: Craviso GL, Musacchio JM. High-affinity dextromethorphan binding sites in guinea pig brain. II. Competition experiments. Mol Pharmacol. 1983 May;23(3):629-40. PMID: 6865909. 5: CLARKE EG. A NOTE ON THE DIFFERENTIATION BETWEEN DEXTRO- AND LAEVOPROPOXYPHENE. J Pharm Pharmacol. 1963 Sep;15:624-5. doi: 10.1111/j.2042-7158.1963.tb12848.x. PMID: 14059611.