Mapenterol HCl | CAS#54238-51-6 | β2-AR agonist

MedKoo Cat#: 464939 | Name: Mapenterol HCl

Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Mapenterol is an agonist of β2-adrenergic receptors (β2-ARs). It has been used as a standard for the simultaneous detection of multiple drug residues in commercial livestock synovial fluids by GC-MS. It has been used as an illicit feed additive to promote growth in livestock.

Chemical Structure

Mapenterol HCl

CAS#54238-51-6

Theoretical Analysis

MedKoo Cat#: 464939

Name: Mapenterol HCl

CAS#: 54238-51-6

Chemical Formula: C14H21Cl2F3N2O

Exact Mass: 0.0000

Molecular Weight: 361.23

Elemental Analysis: C, 46.55; H, 5.86; Cl, 19.63; F, 15.78; N, 7.76; O, 4.43

Price and Availability

Size	Price	Availability
10mg	USD 350.00	2 Weeks
25mg	USD 600.00	2 Weeks
50mg	USD 950.00	2 Weeks

Bulk Inquiry

Buy Now

Add to Cart

Related CAS #

No Data

Synonym

Mapenterol HCl; Mapenterol hydrochloride;

IUPAC/Chemical Name

1-(4-amino-3-chloro-5-(trifluoromethyl)phenyl)-2-(tert-pentylamino)ethan-1-ol hydrochloride

InChi Key

LWJSGOMCMMDPEN-UHFFFAOYSA-N

InChi Code

InChI=1S/C14H20ClF3N2O.ClH/c1-4-13(2,3)20-7-11(21)8-5-9(14(16,17)18)12(19)10(15)6-8;/h5-6,11,20-21H,4,7,19H2,1-3H3;1H

SMILES Code

FC(C1=CC(C(O)CNC(CC)(C)C)=CC(Cl)=C1N)(F)F.Cl

Appearance

Solid powder

Purity

>95% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 361.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Mastrianni KR, Metavarayuth K, Brewer WE, Wang Q. Analysis of 10 β-agonists in pork meat using automated dispersive pipette extraction and LC-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 May 1;1084:64-68. doi: 10.1016/j.jchromb.2018.03.026. Epub 2018 Mar 14. PMID: 29571118. 2: Zhao L, Yang S, Cheng Y, Hou C, You X, Zhao J, Zhang Y, He W. Identification of transcriptional biomarkers by RNA-sequencing for improved detection of β2-agonists abuse in goat skeletal muscle. PLoS One. 2017 Jul 26;12(7):e0181695. doi: 10.1371/journal.pone.0181695. PMID: 28746361; PMCID: PMC5528896. 3: Li T, Cao J, Li Z, Wang X, He P. Broad screening and identification of β-agonists in feed and animal body fluid and tissues using ultra-high performance liquid chromatography-quadrupole-orbitrap high resolution mass spectrometry combined with spectra library search. Food Chem. 2016 Feb 1;192:188-96. doi: 10.1016/j.foodchem.2015.06.104. Epub 2015 Jun 30. PMID: 26304337. 4: Bi S, Zhao T, Wang Y, Zhou H. Study on the interactions of mapenterol with serum albumins using multi-spectroscopy and molecular docking. Luminescence. 2016 Mar;31(2):372-379. doi: 10.1002/bio.2969. Epub 2015 Jul 14. PMID: 26179292. 5: Tao Y, Zhu F, Chen D, Xie S, Yuanhu P, Wang X, Liu Z, Peng D, Yuan Z. Evaluation of matrix solid-phase dispersion extraction for 11 β-agonists in swine feed by liquid chromatography with electrospray ionization tandem mass spectrometry. J Sep Sci. 2014 Sep;37(18):2574-82. doi: 10.1002/jssc.201400402. Epub 2014 Aug 1. PMID: 24981594. 6: Us MF, Alshana U, Lubbad I, Göğer NG, Ertaş N. Dispersive liquid-liquid microextraction based on solidification of floating organic drop combined with field-amplified sample injection in capillary electrophoresis for the determination of beta(2)-agonists in bovine urine. Electrophoresis. 2013 Mar;34(6):854-61. doi: 10.1002/elps.201200348. PMID: 23335131. 7: Nie J, Zhu M, Lian J, Pan Y, Deng X, Hu C. [Determination of fifteen beta- agonists in animal urine by high performance liquid chromatography-tandem mass spectrometry]. Se Pu. 2010 Aug;28(8):759-64. Chinese. doi: 10.3724/sp.j.1123.2010.00759. PMID: 21261043. 8: Juan C, Igualada C, Moragues F, León N, Mañes J. Development and validation of a liquid chromatography tandem mass spectrometry method for the analysis of beta-agonists in animal feed and drinking water. J Chromatogr A. 2010 Sep 24;1217(39):6061-8. doi: 10.1016/j.chroma.2010.07.034. Epub 2010 Aug 5. PMID: 20727526. 9: Ramos F, Baeta ML, Reis J, Silveira MI. Evaluation of the illegal use of clenbuterol in Portuguese cattle farms from drinking water, urine, hair and feed samples. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2009 Jun;26(6):814-20. doi: 10.1080/02652030902729908. PMID: 19680955. 10: Granja RH, Montes Niño AM, Rabone F, Montes Niño RE, Cannavan A, Salerno AG. Validation of radioimmunoassay screening methods for beta-agonists in bovine liver according to Commission Decision 2002/657/EC. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2008 Dec;25(12):1475-81. doi: 10.1080/02652030802308464. PMID: 19680857. 11: Di Corcia D, Morra V, Pazzi M, Vincenti M. Simultaneous determination of beta2-agonists in human urine by fast-gas chromatography/mass spectrometry: method validation and clinical application. Biomed Chromatogr. 2010 Apr;24(4):358-66. doi: 10.1002/bmc.1300. PMID: 19642085. 12: Moragues F, Igualada C. How to decrease ion suppression in a multiresidue determination of beta-agonists in animal liver and urine by liquid chromatography-mass spectrometry with ion-trap detector. Anal Chim Acta. 2009 Apr 1;637(1-2):193-5. doi: 10.1016/j.aca.2008.10.065. Epub 2008 Nov 5. PMID: 19286029. 13: Widstrand C, Larsson F, Fiori M, Civitareale C, Mirante S, Brambilla G. Evaluation of MISPE for the multi-residue extraction of beta-agonists from calves urine. J Chromatogr B Analyt Technol Biomed Life Sci. 2004 May 5;804(1):85-91. doi: 10.1016/j.jchromb.2003.12.034. PMID: 15093162. 14: Spisso BF, Lopes CC, Marques MA, Neto FR. Determination of beta2-agonists in bovine urine: comparison of two extraction/clean-up procedures for high- resolution gas chromatography-mass spectrometry analysis. J Anal Toxicol. 2000 Mar;24(2):146-52. doi: 10.1093/jat/24.2.146. PMID: 10732954. 15: Haasnoot W, Stouten P, Schilt R, Hooijerink D. A fast immunoassay for the screening of beta-agonists in hair. Analyst. 1998 Dec;123(12):2707-10. doi: 10.1039/a805041d. PMID: 10435328. 16: Ramos F, Santos C, Silva A, da Silveira MI. Beta2-adrenergic agonist residues: simultaneous methyl- and butylboronic derivatization for confirmatory analysis by gas chromatography-mass spectrometry. J Chromatogr B Biomed Sci Appl. 1998 Sep 25;716(1-2):366-70. doi: 10.1016/s0378-4347(98)00292-8. PMID: 9824253. 17: Groot MJ, Schilt R, Ossenkoppele JS, Berende PL, Haasnoot W. Combinations of growth promoters in veal calves: consequences for screening and confirmation methods. Zentralbl Veterinarmed A. 1998 Sep;45(6-7):425-40. doi: 10.1111/j.1439-0442.1998.tb00845.x. PMID: 9793473. 18: Ramos F, Castilho MC, Silveira MI. Occurrence of beta 2-adrenergic agonist residues in urine of animal meat producers in Portugal. J AOAC Int. 1998 May- Jun;81(3):544-8. PMID: 9606919. 19: Sangiorgi E, Curatolo M. Application of a sequential analytical procedure for the detection of the beta-agonist brombuterol in bovine urine samples. J Chromatogr B Biomed Sci Appl. 1997 Jun 6;693(2):468-78. doi: 10.1016/s0378-4347(97)00056-x. PMID: 9210454. 20: Cai J, Henion J. Quantitative multi-residue determination of beta-agonists in bovine urine using on-line immunoaffinity extraction-coupled column packed capillary liquid chromatography-tandem mass spectrometry. J Chromatogr B Biomed Sci Appl. 1997 Apr 11;691(2):357-70. doi: 10.1016/s0378-4347(96)00433-1. PMID: 9174272.