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MedKoo Cat#: 464935 | Name: MOR 14
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

MOR 14 is an inhibitor of α-glucosidases and glycoprotein processing. It inhibits the rabbit intestinal α-glucosidases sucrase and maltase (IC50s = 0.068 and 0.46 µg/ml, respectively) and R. niveus glucoamylase (IC50s = 1.6 and 4.7 µg/ml with starch or maltose as substrates, respectively). It is selective for these enzymes over β-glucosidase (IC50 = 363 µg/ml). MOR 14 inhibits highly pathogenic avian influenza (HPAI) oligosaccharide processing in HPAI-infected chicken embryo cells. It reduces the cytopathic effect of HIV in infected Karpas-45 T cells. MOR 14 also inhibits postprandial increases in blood glucose levels in sucrose-loaded rats (ED50 = 5.8 mg/kg).

Chemical Structure

MOR 14
MOR 14
CAS#69567-10-8

Theoretical Analysis

MedKoo Cat#: 464935

Name: MOR 14

CAS#: 69567-10-8

Chemical Formula: C7H15NO4

Exact Mass: 177.1001

Molecular Weight: 177.20

Elemental Analysis: C, 47.45; H, 8.53; N, 7.90; O, 36.12

Price and Availability

Size Price Availability Quantity
1mg USD 270.00 2 Weeks
5mg USD 680.00 2 Weeks
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Related CAS #
No Data
Synonym
MOR 14; MOR14; MOR-14; N-Methylmoranoline; N Methylmoranoline; N-methyl dNM; N methyl dNM; N-methyl DNJ; N methyl DNJ; N-Methyl-1-Deoxynojirimycin;
IUPAC/Chemical Name
(2R,3R,4R,5S)-2-(hydroxymethyl)-1-methylpiperidine-3,4,5-triol
InChi Key
AAKDPDFZMNYDLR-XZBKPIIZSA-N
InChi Code
InChI=1S/C7H15NO4/c1-8-2-5(10)7(12)6(11)4(8)3-9/h4-7,9-12H,2-3H2,1H3/t4-,5+,6-,7-/m1/s1
SMILES Code
OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 177.20 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Arai M, Minatoguchi S, Takemura G, Uno Y, Kariya T, Takatsu H, Fujiwara T, Higashioka M, Yoshikuni Y, Fujiwara H. N-methyl-1-deoxynojirimycin (MOR-14), an alpha-glucosidase inhibitor, markedly reduced infarct size in rabbit hearts. Circulation. 1998 Apr 7;97(13):1290-7. doi: 10.1161/01.cir.97.13.1290. PMID: 9570200. 2: Nishida Y, Minatoguchi S, Arai M, Takemura G, Uno Y, Hashimoto K, Wang N, Chen XH, Fujiwara T, Fujiwara H. N-methyl-1-deoxynojirimycin (MOR-14), an alpha- glucosidase inhibitor, markedly improves postischemic left ventricular dysfunction. Heart Vessels. 2000;15(6):268-73. doi: 10.1007/s003800070004. PMID: 11766064. 3: Arai M, Minatoguchi S, Kumada H, Uno Y, Nishida Y, Hashimoto K, Wang N, Takemura G, Fujiwara T, Higashioka M, Kuwano K, Fujiwara H. Role of protein kinase C in the reduction of infarct size by N-methyl-1-deoxynojirimycin, an alpha-1,6-glucosidase inhibitor. Br J Pharmacol. 2001 Jul;133(5):635-42. doi: 10.1038/sj.bjp.0704107. PMID: 11429386; PMCID: PMC1572825. 4: Romero PA, Datema R, Schwarz RT. N-methyl-1-deoxynojirimycin, a novel inhibitor of glycoprotein processing, and its effect on fowl plague virus maturation. Virology. 1983 Oct 15;130(1):238-42. doi: 10.1016/0042-6822(83)90133-2. PMID: 6636538. 5: Romero PA, Friedlander P, Herscovics A. Deoxynojirimycin inhibits the formation of Glc3Man9GlcNAc2-PP-dolichol in intestinal epithelial cells in culture. FEBS Lett. 1985 Apr 8;183(1):29-32. doi: 10.1016/0014-5793(85)80947-9. PMID: 3156765. 6: Faber ED, Oosting R, Neefjes JJ, Ploegh HL, Meijer DK. Distribution and elimination of the glycosidase inhibitors 1-deoxymannojirimycin and N-methyl-1-deoxynojirimycin in the rat in vivo. Pharm Res. 1992 Nov;9(11):1442-50. doi: 10.1023/a:1015810913257. PMID: 1475231. 7: DiCioccio RA, Mahoney CM. Effect of glycosylation inhibitors and acidotropic amines on the synthesis, processing, and intracellular-extracellular distribution of alpha-L-fucosidase in B-lymphoblastoid cells. Carbohydr Res. 1990 Mar 25;197:217-26. doi: 10.1016/0008-6215(90)84144-j. PMID: 2140711. 8: McDowell W, Romero PA, Datema R, Schwarz RT. Glucose trimming and mannose trimming affect different phases of the maturation of Sindbis virus in infected BHK cells. Virology. 1987 Nov;161(1):37-44. doi: 10.1016/0042-6822(87)90168-1. PMID: 2960074; PMCID: PMC7131543. 9: Jarvis DL, Oker-Blom C, Summers MD. Role of glycosylation in the transport of recombinant glycoproteins through the secretory pathway of lepidopteran insect cells. J Cell Biochem. 1990 Apr;42(4):181-91. doi: 10.1002/jcb.240420402. PMID: 2341487. 10: Spiro RC, Casteel HE, Laufer DM, Reisfeld RA, Harper JR. Post-translational addition of chondroitin sulfate glycosaminoglycans. Role of N-linked oligosaccharide addition, trimming, and processing. J Biol Chem. 1989 Jan 25;264(3):1779-86. PMID: 2492282.