Norquetiapine Free Base | CAS# 5747-48-8 (free base) | antidepressant efficacy

MedKoo Cat#: 414483 | Name: Norquetiapine Free Base

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Norquetiapine Free Base exhibits distinct pharmacological activity from quetiapine and plays a fundamental role in its antidepressant efficacy.

Chemical Structure

Norquetiapine Free Base

CAS#5747-48-8 (free base)

Theoretical Analysis

MedKoo Cat#: 414483

Name: Norquetiapine Free Base

CAS#: 5747-48-8 (free base)

Chemical Formula: C17H17N3S

Exact Mass: 295.1143

Molecular Weight: 295.40

Elemental Analysis: C, 69.12; H, 5.80; N, 14.22; S, 10.85

Price and Availability

Size	Price	Availability	Quantity
10mg	USD 250.00	2 Weeks
25mg	USD 450.00	2 Weeks

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Related CAS #

5747-48-8 (free base); 111974-74-4 (2HCl)

Synonym

Norquetiapine Free Base

IUPAC/Chemical Name

11-(piperazin-1-yl)dibenzo[b,f][1,4]thiazepine

InChi Key

JLOAJISUHPIQOX-UHFFFAOYSA-N

InChi Code

InChI=1S/C17H17N3S/c1-3-7-15-13(5-1)17(20-11-9-18-10-12-20)19-14-6-2-4-8-16(14)21-15/h1-8,18H,9-12H2

SMILES Code

N1(C2=Nc3c(Sc4c2cccc4)cccc3)CCNCC1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 295.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Kim DH, Park KS, Park SH, Hahn SJ, Choi JS. Norquetiapine blocks the human cardiac sodium channel Nav1.5 in a state-dependent manner. Eur J Pharmacol. 2020 Oct 15;885:173532. doi: 10.1016/j.ejphar.2020.173532. Epub 2020 Sep 1. PMID: 32882214. 2: Lee HJ, Choi JS, Choi BH, Hahn SJ. Effects of norquetiapine, the active metabolite of quetiapine, on cloned hERG potassium channels. Neurosci Lett. 2018 Jan 18;664:66-73. doi: 10.1016/j.neulet.2017.11.029. Epub 2017 Nov 11. PMID: 29133173. 3: Almeida F, Albuquerque E, Murta I. Delirium Induced by Quetiapine and the Potential Role of Norquetiapine. Front Neurosci. 2019 Aug 20;13:886. doi: 10.3389/fnins.2019.00886. PMID: 31481872; PMCID: PMC6710379. 4: López-Muñoz F, Alamo C. Active metabolites as antidepressant drugs: the role of norquetiapine in the mechanism of action of quetiapine in the treatment of mood disorders. Front Psychiatry. 2013 Sep 12;4:102. doi: 10.3389/fpsyt.2013.00102. PMID: 24062697; PMCID: PMC3770982. 5: Cross AJ, Widzowski D, Maciag C, Zacco A, Hudzik T, Liu J, Nyberg S, Wood MW. Quetiapine and its metabolite norquetiapine: translation from in vitro pharmacology to in vivo efficacy in rodent models. Br J Pharmacol. 2016 Jan;173(1):155-66. doi: 10.1111/bph.13346. Epub 2015 Dec 1. PMID: 26436896; PMCID: PMC4813385. 6: Rovera C, Esposito CM, Ciappolino V, Cattaneo D, Baldelli S, Clementi E, Altamura AC, Buoli M. Quetiapine-Induced Hypomania and its Association with Quetiapine/Norquetiapine Plasma Concentrations: A Case Series of Bipolar Type 2 Patients. Drug Saf Case Rep. 2017 Oct 23;4(1):13. doi: 10.1007/s40800-017-0057-9. PMID: 29063217; PMCID: PMC5653679. 7: Park CW, Lee HJ, Oh DW, Kang JH, Han CS, Kim DW. Preparation and in vitro/in vivo evaluation of PLGA microspheres containing norquetiapine for long-acting injection. Drug Des Devel Ther. 2018 Apr 5;12:711-719. doi: 10.2147/DDDT.S151437. PMID: 29670329; PMCID: PMC5896679. 8: Rasmussen H, Ebdrup BH, Aggernaes B, Lublin H, Oranje B, Pinborg LH, Knudsen GM, Glenthøj B. Norquetiapine and depressive symptoms in initially antipsychotic-naive first-episode schizophrenia. J Clin Psychopharmacol. 2013 Apr;33(2):266-9. doi: 10.1097/JCP.0b013e318287acc9. PMID: 23422401. 9: Kim DW, Weon KY, Hong EP, Chung EK, Lee KT. Comparative Physicochemical and Pharmacokinetic Properties of Quetiapine and Its Active Metabolite Norquetiapine. Chem Pharm Bull (Tokyo). 2016;64(11):1546-1554. doi: 10.1248/cpb.c16-00223. PMID: 27803466. 10: Altamura AC, Moliterno D, Paletta S, Buoli M, Dell'osso B, Mauri MC, Bareggi SR. Effect of quetiapine and norquetiapine on anxiety and depression in major psychoses using a pharmacokinetic approach: a prospective observational study. Clin Drug Investig. 2012 Mar 1;32(3):213-9. doi: 10.2165/11597330-000000000-00000. PMID: 22299714.