YM281 is a proteolysis-target chimera (PROTAC)-based EZH2 degrader. YM281 induced robust cell viability inhibition in diffuse large B-cell lymphoma (DLBCL) and other subtypes of lymphomas, outperforming a clinically used EZH2 inhibitor EPZ6438 (tazemetostat) that was only effective against DLBCL. The EZH2 degrader displayed promising antitumor activities in lymphoma xenografts and patient-derived primary.
MedKoo Cat#: 464924
Name: YM281
CAS#: 2230914-84-6
Chemical Formula: C56H71N7O9S
Exact Mass: 1017.5034
Molecular Weight: 1018.28
Elemental Analysis: C, 66.05; H, 7.03; N, 9.63; O, 14.14; S, 3.15
The following data is based on the product molecular weight 1,018.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
