Synonym
ODZ10117; ODZ 10117; ODZ-10117;
IUPAC/Chemical Name
3-((2,4-dichlorophenoxy)methyl)-5-(trichloromethyl)-1,2,4-oxadiazole
InChi Key
KHJPDFJCROAIDO-UHFFFAOYSA-N
InChi Code
InChI=1S/C10H5Cl5N2O2/c11-5-1-2-7(6(12)3-5)18-4-8-16-9(19-17-8)10(13,14)15/h1-3H,4H2
SMILES Code
ClC1=CC=C(OCC2=NOC(C(Cl)(Cl)Cl)=N2)C(Cl)=C1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
362.41
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Kim BH, Lee H, Park CG, Jeong AJ, Lee SH, Noh KH, Park JB, Lee CG, Paek SH, Kim H, Ye SK. STAT3 Inhibitor ODZ10117 Suppresses Glioblastoma Malignancy and Prolongs Survival in a Glioblastoma Xenograft Model. Cells. 2020 Mar 15;9(3):722. doi: 10.3390/cells9030722. PMID: 32183406; PMCID: PMC7140655.
2: Kim BH, Lee H, Song Y, Park JS, Gadhe CG, Choi J, Lee CG, Pae AN, Kim S, Ye SK. Development of Oxadiazole-Based ODZ10117 as a Small-Molecule Inhibitor of STAT3 for Targeted Cancer Therapy. J Clin Med. 2019 Nov 2;8(11):1847. doi: 10.3390/jcm8111847. PMID: 31684051; PMCID: PMC6912340.
