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MedKoo Cat#: 577038 | Name: Tomoxiprole

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tomoxiprole is a cyclooxygenase-2-selective inhibitor.

Chemical Structure

Tomoxiprole
CAS#76145-76-1

Theoretical Analysis

MedKoo Cat#: 577038

Name: Tomoxiprole

CAS#: 76145-76-1

Chemical Formula: C21H20N2O

Exact Mass: 316.1576

Molecular Weight: 316.40

Elemental Analysis: C, 79.72; H, 6.37; N, 8.85; O, 5.06

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
MDL-035; MDL 035; MDL035; Tomoxiprole
IUPAC/Chemical Name
3H-Naphth(1,2-d)imidazole, 2-(4-methoxyphenyl)-3-(1-methylethyl)-
InChi Key
XVDXNSRMHBAVAX-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H20N2O/c1-14(2)23-19-13-10-15-6-4-5-7-18(15)20(19)22-21(23)16-8-11-17(24-3)12-9-16/h4-14H,1-3H3
SMILES Code
COc1ccc(cc1)c2nc3c4ccccc4ccc3n2C(C)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 316.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. West RE Jr, Williams SM, She HS, Carruthers NI, Egan RW, Billah MM. Tomoxiprole selectively inhibits cyclooxygenase-2. Prostaglandins. 1997 Dec;54(6):891-8. doi: 10.1016/s0090-6980(97)00187-1. PMID: 9533184. 2. Hosseinzadeh H, Mazaheri F, Ghodsi R. Pharmacological effects of a synthetic quinoline, a hybrid of tomoxiprole and naproxen, against acute pain and inflammation in mice: a behavioral and docking study. Iran J Basic Med Sci. 2017 Apr;20(4):446-450. doi: 10.22038/IJBMS.2017.8588. PMID: 28804615; PMCID: PMC5425928. 3. Assandri A, Bernareggi A, Ripamonti A, Perazzi A, Toja E. Pharmacokinetics and metabolism of tomoxiprole, a new analgesic antiinflammatory agent, in the rat. Eur J Drug Metab Pharmacokinet. 1985 Apr-Jun;10(2):161-70. doi: 10.1007/BF03189711. PMID: 4043144.