Nociceptin | CAS# 170713-75-4 | Opioid receptor-like ORL1 receptor agonist

MedKoo Cat#: 414448 | Name: Nociceptin

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Nociceptin is a 17-amino acid-long peptide from rat brain; resembles dynorphin A; an endogenous agonist of the opioid receptor-like ORL1 receptor; GenBank AF348323 (human).

Chemical Structure

Nociceptin

CAS#170713-75-4

Theoretical Analysis

MedKoo Cat#: 414448

Name: Nociceptin

CAS#: 170713-75-4

Chemical Formula: C79H129N27O22

Exact Mass: 1807.9805

Molecular Weight: 1809.07

Elemental Analysis: C, 52.45; H, 7.19; N, 20.91; O, 19.46

Price and Availability

Size	Price	Availability	Quantity
1mg	USD 450.00	2 Weeks

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Related CAS #

No Data

Synonym

Nociceptin; Orphanin FQ

IUPAC/Chemical Name

L-Glutamine, L-phenylalanylglycylglycyl-L-phenylalanyl-L-threonylglycyl-L-alanyl-L-arginyl-L-lysyl-L-seryl-L-alanyl-L-arginyl-L-lysyl-L-leucyl-L-alanyl-L-asparaginyl-

InChi Key

PULGYDLMFSFVBL-SMFNREODSA-N

InChi Code

InChI=1S/C79H129N27O22/c1-41(2)33-54(72(122)95-44(5)66(116)103-56(36-59(84)110)73(123)102-53(77(127)128)27-28-58(83)109)104-70(120)49(23-13-15-29-80)100-69(119)52(26-18-32-90-79(87)88)99-65(115)43(4)96-75(125)57(40-107)105-71(121)50(24-14-16-30-81)101-68(118)51(25-17-31-89-78(85)86)98-64(114)42(3)94-61(112)39-93-76(126)63(45(6)108)106-74(124)55(35-47-21-11-8-12-22-47)97-62(113)38-91-60(111)37-92-67(117)48(82)34-46-19-9-7-10-20-46/h7-12,19-22,41-45,48-57,63,107-108H,13-18,23-40,80-82H2,1-6H3,(H2,83,109)(H2,84,110)(H,91,111)(H,92,117)(H,93,126)(H,94,112)(H,95,122)(H,96,125)(H,97,113)(H,98,114)(H,99,115)(H,100,119)(H,101,118)(H,102,123)(H,103,116)(H,104,120)(H,105,121)(H,106,124)(H,127,128)(H4,85,86,89)(H4,87,88,90)/t42-,43-,44-,45+,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,63-/m0/s1

SMILES Code

CC(C[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CCC(N)=O)=O)CC(N)=O)=O)C)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@H]([C@H](O)C)NC([C@@H](NC(CNC(CNC([C@H](Cc1ccccc1)N)=O)=O)=O)Cc2ccccc2)=O)=O)=O)C)=O)CCCNC(N)=N)=O)CCCCN)=O)CO)=O)C)=O)CCCNC(N)=N)=O)CCCCN)=O)C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,809.07 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Tollefson S, Himes M, Narendran R. Imaging corticotropin-releasing-factor and nociceptin in addiction and PTSD models. Int Rev Psychiatry. 2017 Dec;29(6):567-579. doi: 10.1080/09540261.2017.1404445. Epub 2017 Dec 12. PMID: 29231765. 2: Wtorek K, Janecka A. Potential of Nociceptin/Orphanin FQ Peptide Analogs for Drug Development. Chem Biodivers. 2021 Jan;18(1):e2000871. doi: 10.1002/cbdv.202000871. Epub 2020 Dec 22. PMID: 33351271. 3: Munksgaard SB, Ertsey C, Frandsen E, Bendtsen L, Tekes K, Jensen RH. Circulating nociceptin and CGRP in medication-overuse headache. Acta Neurol Scand. 2019 Mar;139(3):269-275. doi: 10.1111/ane.13053. Epub 2018 Dec 11. PMID: 30457160. 4: Eto K. Nociceptin and meiosis during spermatogenesis in postnatal testes. Vitam Horm. 2015;97:167-86. doi: 10.1016/bs.vh.2014.10.003. Epub 2015 Jan 14. PMID: 25677772. 5: Andero R. Nociceptin and the nociceptin receptor in learning and memory. Prog Neuropsychopharmacol Biol Psychiatry. 2015 Oct 1;62:45-50. doi: 10.1016/j.pnpbp.2015.02.007. Epub 2015 Feb 24. PMID: 25724763; PMCID: PMC4458422. 6: Thomas RC, Bath MF, Stover CM, Lambert DG, Thompson JP. Exploring LPS-induced sepsis in rats and mice as a model to study potential protective effects of the nociceptin/orphanin FQ system. Peptides. 2014 Nov;61:56-60. doi: 10.1016/j.peptides.2014.08.009. Epub 2014 Aug 23. PMID: 25161013. 7: Thomas R, Stover C, Lambert DG, Thompson JP. Nociceptin system as a target in sepsis? J Anesth. 2014 Oct;28(5):759-67. doi: 10.1007/s00540-014-1818-6. Epub 2014 Apr 12. PMID: 24728719. 8: Verbeek TA, Jarbadan NR, Davis C, Caldwell J. Nociceptin is present in synovial fluid of patients undergoing total knee arthroplasty. J Orthop Surg Res. 2020 Jul 16;15(1):266. doi: 10.1186/s13018-020-01789-1. PMID: 32677997; PMCID: PMC7364622. 9: Moulédous L. The Nociceptin/Orphanin FQ System and the Regulation of Memory. Handb Exp Pharmacol. 2019;254:259-278. doi: 10.1007/164_2018_185. PMID: 30430261. 10: Murphy NP. The nociceptin/orphanin FQ system as a target for treating alcoholism. CNS Neurol Disord Drug Targets. 2010 Mar;9(1):87-93. doi: 10.2174/187152710790966713. PMID: 20201819.