MedKoo Cat#: 414443 | Name: NNC-45-0095

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NNC-45-0095 is a synthetic nonsteroidal selective estrogen receptor modulator which was under development by Novo Nordisk for the treatment of postmenopausal osteoporosis but was never marketed.

Chemical Structure

NNC-45-0095
NNC-45-0095
CAS#217318-90-6

Theoretical Analysis

MedKoo Cat#: 414443

Name: NNC-45-0095

CAS#: 217318-90-6

Chemical Formula: C18H15NO

Exact Mass: 261.1154

Molecular Weight: 261.32

Elemental Analysis: C, 82.73; H, 5.79; N, 5.36; O, 6.12

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
NNC-45-0095
IUPAC/Chemical Name
1-ethyl-2-(4-hydroxyphenyl)pyrrolo(2,1,5-cd)indolizine
InChi Key
GBHFDPQPLXKNIU-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H15NO/c1-2-15-16-5-3-4-13-8-11-17(19(13)16)18(15)12-6-9-14(20)10-7-12/h3-11,20H,2H2,1H3
SMILES Code
OC1=CC=C(C2=C(C=C3)N4C3=CC=CC4=C2CC)C=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 261.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Jørgensen AS, Jacobsen P, Christiansen LB, Bury PS, Kanstrup A, Thorpe SM, Bain S, Naerum L, Wassermann K. Synthesis and pharmacology of a novel pyrrolo[2,1,5-cd] indolizine (NNC 45-0095), a high affinity non-steroidal agonist for the estrogen receptor. Bioorg Med Chem Lett. 2000 Feb 21;10(4):399-402. doi: 10.1016/s0960-894x(00)00015-9. PMID: 10714509.