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MedKoo Cat#: 577025 | Name: MDL-72567

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MDL-72567 is a dihydropyridine calcium antagonist that causes vasodilation and direct sinus bradycardia.

Chemical Structure

MDL-72567
MDL-72567
CAS#94985-29-2

Theoretical Analysis

MedKoo Cat#: 577025

Name: MDL-72567

CAS#: 94985-29-2

Chemical Formula: C20H18N2O6

Exact Mass: 382.1165

Molecular Weight: 382.37

Elemental Analysis: C, 62.82; H, 4.75; N, 7.33; O, 25.10

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
MDL72567; MDL 72567; MDL-72567
IUPAC/Chemical Name
3-Pyridinecarboxylic acid, 5-(2-furanylcarbonyl)-1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, methyl ester
InChi Key
SYZMOVBYGJLHNJ-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H18N2O6/c1-11-16(19(23)15-9-6-10-28-15)18(17(12(2)21-11)20(24)27-3)13-7-4-5-8-14(13)22(25)26/h4-10,18,21H,1-3H3
SMILES Code
COC(=O)C1=C(C)NC(=C(C1c2ccccc2[N+](=O)[O-])C(=O)c3occc3)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 382.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Spedding M, DiFrancesco GF, Mir AK, Petty MA, Berg C, Gittos M. MDL 72567, a dihydropyridine calcium-antagonist, that causes vasodilation and direct sinus bradycardia. J Cardiovasc Pharmacol. 1987 Jul;10(1):62-71. doi: 10.1097/00005344-198707000-00009. PMID: 2441155. 2. Petty MA, Spedding M, Di Francesco GF. Comparison between the effects of MDL 72567 and nifedipine on various cardiovascular parameters in conscious sinoaortic-denervated rats and sham-operated controls. J Cardiovasc Pharmacol. 1987 Oct;10(4):456-61. doi: 10.1097/00005344-198710000-00012. PMID: 2444800. 3. Huebert ND, Spedding M, Haegele KD. Quantitative analysis of the dihydropyridines, 3-(2-furoyl)-5-methoxycarbonyl-2,6-dimethyl-4-(2-nitrophenyl)- 1,4-dihydropyridine and nifedipine, by high-performance liquid chromatography with electrochemical detection. J Chromatogr. 1986 Feb 26;353:175-80. doi: 10.1016/s0021-9673(01)87086-2. PMID: 3754560.